Storage and supply for vessel holders

• US 9,684,007 B2
• Filed: 12/11/2014
• Issued: 06/20/2017
• Est. Priority Date: 12/19/2013
• Status: Active Grant

• Current Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Original Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Inventors: Schacher, Gottlieb, Reisch, Dietmar
• Primary Examiner(s): Wecker, Jennifer
• Application Number:
  US14/567,531
• Publication Number:
  US 20150177268A1
• Time in Patent Office: 922 Days
• CPC Class Codes: B01L 9/06 Test-tube stands; Test-tube holders
• CPC Class Codes: B65G 2201/0261 Puck as article support
• CPC Class Codes: B65G 65/00 Loading or unloading of vehicles B65G67/00
• CPC Class Codes: G01N 1/28 Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Qmounting specimens on microscopic slides G02B21/34; means for supporting the objects or the materials to be analysed in electron microscopes H01J37/20 ; laboratory gas handling apparatus B01L5/00
• CPC Class Codes: G01N 2035/0462 Buffers [FIFO] or stacks [LIFO] for holding carriers between operations
• CPC Class Codes: G01N 2035/0465 Loading or unloading the conveyor
• CPC Class Codes: G01N 2035/0467 Switching points ("aiguillages")
• CPC Class Codes: G01N 2035/0491 Position sensing, encoding; closed-loop control
• CPC Class Codes: G01N 33/00 Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
• CPC Class Codes: G01N 35/0099 comprising robots or similar manipulators robots per se B25J
• CPC Class Codes: G01N 35/02 using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations G01N35/0098 and G01N35/0099 take precedence
• CPC Class Codes: G01N 35/025 having a carousel or turntable for reaction cells or cuvettes
• CPC Class Codes: Y10T 436/2575 Volumetric liquid transfer

Abstract

An automated system and method for processing vessels containing biological samples are presented. The system comprises vessel holders, a transport medium for transporting the vessel holders between the components of the system, a work cell for processing, a storage module for empty vessel holders, wherein the storage module is connected to the transport medium, a robotic manipulator for engaging and/or disengaging the vessels with empty vessel holders, an empty vessel holder transfer unit for introducing empty vessel holders into or retrieving them from the storage module, and an empty vessel holder detection unit, including an empty vessel holder detector for discriminating between filled and empty vessel holders as well as a transfer initiator configured to initiate the introduction or re-introduction of an empty vessel holder detected in or on the transport medium into the storage module by the empty vessel holder transfer unit.

Claims

1. An automated system for processing vessels containing biological samples, the automated system comprising:

a plurality of vessel holders for the vessels containing biological samples;

a transport medium for transporting the vessel holders within the automated system;

a work cell for processing the vessels containing biological samples;

a cylinder-shaped silo storage module for empty members of the plurality of vessel holders, wherein the cylinder-shaped silo storage module is connected to the transport medium via an empty vessel holder transfer unit, which comprises a vertical and lateral moving shuttle system, and is configured for retrieving empty vessel holders from the transport medium and introducing them into the cylinder-shaped silo storage module, or retrieving empty vessel holders from the cylinder-shaped silo storage module and placing them in or on the transport medium;

a robotic manipulator for engaging and/or disengaging the vessels containing biological samples with the empty members of the plurality of vessel holders;

a control unit for controlling the automated system; and

an empty vessel holder detection unit configured for detecting empty vessel holders in or on the transport medium, the empty vessel holder detection unit comprising an empty vessel holder detector for discriminating between filled and empty vessel holders, and a transfer initiator configured to initiate the introduction or re-introduction of an empty vessel holder detected in or on the transport medium into the cylinder-shaped silo storage module by the empty vessel holder transfer unit.

2. The automated system of claim 1, wherein the transfer initiator of the empty vessel holder detection unit comprises a programmable logic controller configured to direct an empty vessel holder detected in or on the transport medium on the shortest possible route to the cylinder-shaped silo storage module.

3. The automated system of claim 2, wherein the programmable logic controller flags the detected empty vessel holder for the empty vessel holder transfer unit to retrieve the detected empty vessel holder from the transport medium and introduce the detected empty vessel holder into the cylinder-shaped silo storage module.

4. The automated system of claim 1, wherein the empty vessel holder detector comprises a mechanical, electrical, electromechanical, electromagnetic, or optical detection system.

5. The automated system of claim 1, wherein the empty vessel holder detector comprises a first indicator located in a first position and a second indicator located in a second position relative to a vessel holder circulating in or on the transport medium, wherein the first position intersects the vessel holder'"'"'s track that it travels along the transport medium, and the second position intersects a vessel'"'"'s track that it travels along the transport medium if present in the vessel holder.

6. The automated system of claim 5, wherein the indicators are photoelectric barriers.

7. The automated system of claim 1, wherein the empty vessel holder detector comprises a weighing system.

8. The automated system of claim 1, wherein the empty vessel holder detector comprises a mechanical barrier located in a position relative to a vessel holder circulating in or on the transport medium, wherein the first position intersects a vessel'"'"'s track that it travels along the transport medium if present in the vessel holder such that a vessel in the vessel holder is deviated by the mechanical barrier relative to an empty vessel holder circulating in or on the transport medium.

9. The automated system of claim 1, wherein each vessel holder comprises an identification tag for detection by the empty vessel holder detection unit.

10. The automated system of claim 1, wherein the transport medium is a conveyor, a rail system or a magnetic surface.

11. The automated system of claim 1, wherein the empty members of the plurality of vessel holders within the cylinder-shaped silo storage module are arranged in a predefined geometrical arrangement.

12. The automated system of claim 1, wherein the cylinder-shaped silo storage module is rotatable and/or comprises rotatable parts for positioning the empty members of the plurality of vessel holders with respect to the transport medium.

13. The automated system of claim 12, wherein the cylinder-shaped silo storage module comprises a rotatable spiral conveyor along which the empty members of the plurality of vessel holders are aligned.

14. The automated system of claim 12, wherein the cylinder-shaped silo storage module comprises a rotatable drum, the rotatable drum comprising multiple tubes aligned at a radius of the rotational axis of the drum, wherein the empty members of the plurality of vessel holders are stacked vertically within the tubes.

15. A method for processing vessels containing biological samples in an automated system, the method comprising:

retrieving an empty vessel holder to a transport medium from a cylinder-shaped silo storage module comprising a plurality of empty vessel holders, wherein the cylinder-shaped silo storage module is connected to the transport medium via an empty vessel holder transfer unit comprising a vertical and lateral moving shuttle system for introducing empty vessel holders from the transport medium into the cylinder-shaped silo storage module or retrieving them from the cylinder-shaped silo storage module to the transport medium by moving vertically and laterally along the cylinder-shaped silo storage module;

engaging a vessel comprising a biological sample to the retrieved empty vessel holder;

transporting the vessel holder with the engaged vessel comprising a biological sample via the transport medium to a work cell;

processing the vessel containing a biological sample within the work cell;

disengaging the vessel comprising a biological sample from the vessel holder;

detecting the empty vessel holder by a an empty vessel holder detection unit for detecting empty vessel holders in or on the transport medium, the empty vessel holder detection unit comprising an empty vessel holder detector for discriminating between filled and empty vessel holders, and a transfer initiator configured to initiate the introduction or re-introduction of an empty vessel holder detected in or on the transport medium into the cylinder-shaped silo storage module by the vertical and lateral moving shuttle system of the empty vessel holder transfer unit; and

re-introducing the empty vessel holder into the cylinder-shaped silo storage module by moving the empty vessel holder vertically and laterally into the cylinder-shaped silo storage module.