Aerosol forming device for use in inhalation therapy

• US 9,687,487 B2
• Filed: 11/13/2013
• Issued: 06/27/2017
• Est. Priority Date: 06/05/2001
• Status: Expired due to Term

• Current Assignee: Alexza Pharmaceuticals Inc. (Grupo Ferrer Internacional SA)
• Original Assignee: Alexza Pharmaceuticals Inc. (Grupo Ferrer Internacional SA)
• Inventors: Hodges, Craig C., Lloyd, Peter M., Rogers, Daniel D., Wensley, Martin J., Mufson, Daniel
• Primary Examiner(s): DOUGLAS, STEVEN O
• Application Number:
  US14/078,577
• Publication Number:
  US 20140060532A1
• Time in Patent Office: 1,322 Days
• Field of Search: 12820016, 12820014, 12820019, 12820018, 12820325, 12820326, 12820414, 12820415, 12820416, 12820316, 12820317, 12820318, 424 45, 424 46
• CPC Class Codes: A61K 31/235 having an aromatic ring attached to a carboxyl group
• CPC Class Codes: A61K 31/4468 having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
• CPC Class Codes: A61K 31/485 Morphinan derivatives, e.g. morphine, codeine
• CPC Class Codes: A61K 31/519 ortho- or peri-condensed with heterocyclic rings
• CPC Class Codes: A61K 9/007 Pulmonary tract; Aromatherapy
• CPC Class Codes: A61K 9/0073 Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy; nasal sprays A61K9/0043; inhalation of vapours of volatile or heated drugs, e.g. essential oils or nicotine, A61K9/007; devices A61M
• CPC Class Codes: A61M 11/001 Particle size control
• CPC Class Codes: A61M 11/02 operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised sprayers for horticulture A01G, A01H; killing insects A01M; air humidifying by nozzles F24F6/14, F24F6/18; cooling by spraying F28B, F28C
• CPC Class Codes: A61M 11/044 with electrodes immersed in the liquid
• CPC Class Codes: A61M 15/00 Inhalators drug delivery in endotracheal tubes A61M16/04
• CPC Class Codes: A61M 15/0028 using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
• CPC Class Codes: A61M 16/109 the humidifying liquid or the beneficial agent
• CPC Class Codes: A61M 2016/0039 in the inspiratory circuit
• CPC Class Codes: A61M 2205/3606 cooled
• CPC Class Codes: A61M 2205/3653 by Joule effect, i.e. electric resistance
• CPC Class Codes: A61M 2205/368 by electromagnetic radiation, e.g. IR waves
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61P 23/00 Anaesthetics
• CPC Class Codes: B05B 17/04 operating with special methods
• CPC Class Codes: B05B 7/1686 involving vaporisation of the material to be sprayed or of an atomising-fluid-generating product

Abstract

Inhalation delivery of aerosols containing small particles from a device that forms drug containing aerosols for use in inhalation therapy. A device for delivering drug containing aerosols for inhalation therapy is provided. The device includes a housing and an airway that has a gas/vapor mixing airway. The airway further includes a subassembly, which has a metallic substrate coated on its surface with a composition comprising a drug.

Claims

1. A device for delivering loxapine containing aerosols comprising:

a housing comprising an inlet, an outlet; and

, an airway extending from the inlet to the outlet;

wherein the airway comprises a gas/vapor mixing area, wherein the airway includes a subassembly, and wherein the subassembly includes a metallic substrate, and wherein a composition comprising loxapine is coated as a thin film between 10μ and

10 nm in thickness on the substrate.