Antithrombogenic hollow fiber membranes and filters

• US 9,687,597 B2
• Filed: 04/19/2016
• Issued: 06/27/2017
• Est. Priority Date: 05/15/2009
• Status: Active Grant

• Current Assignee: Interface Biologics, Inc.
• Original Assignee: Interface Biologics, Inc.
• Inventors: Mullick, Sanjoy, Chang, Weilun, Chen, Hanje, Steedman, Mark A., Esfand, Roseita
• Primary Examiner(s): DRODGE, JOSEPH W
• Application Number:
  US15/132,846
• Publication Number:
  US 20160228632A1
• Time in Patent Office: 434 Days
• Field of Search: 138140, 138145, 138146, 138178, 21032161, 21032178, 21032179, 2103218, 21032187, 21032188, 21032189, 210645, 210 46, 21050023, 21050024, 21050027, 21050036, 21050041, 21050042, 604 501, 604 601, 604 609, 604 19, 604266, 604403
• CPC Class Codes: A61L 33/062 Mixtures of macromolecular compounds
• CPC Class Codes: A61M 1/3672 Means preventing coagulation
• CPC Class Codes: A61M 1/3673 Anticoagulant coating, e.g. Heparin coating
• CPC Class Codes: A61M 2202/0413 Blood
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: B01D 2323/30 Cross-linking
• CPC Class Codes: B01D 2323/36 Introduction of specific chemical groups
• CPC Class Codes: B01D 63/022 Encapsulating hollow fibres
• CPC Class Codes: B01D 63/023 Encapsulating materials
• CPC Class Codes: B01D 67/0093 Chemical modification
• CPC Class Codes: B01D 69/02 characterised by their properties
• CPC Class Codes: B01D 69/08 Hollow fibre membranes manufacture of hollow fibres D01D5/24, D01F1/08
• CPC Class Codes: B01D 69/087 Details relating to the spinning process
• CPC Class Codes: B01D 69/0871 Fibre guidance after spinning through the manufacturing apparatus
• CPC Class Codes: B01D 71/44 Polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds, not provided for in a single one of groups B01D71/26-B01D71/42
• CPC Class Codes: B01D 71/441 Polyvinylpyrrolidone
• CPC Class Codes: B01D 71/68 Polysulfones; Polyethersulfones
• CPC Class Codes: B29C 48/00 Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor extrusion blow-moulding B29C49/04
• CPC Class Codes: B29C 48/05 Filamentary, e.g. strands
• CPC Class Codes: B29C 48/10 flexible, e.g. blown foils
• CPC Class Codes: B29L 2023/00 : Tubular articles B29L2024/00 takes precedence ; catheters B29L2031/7542
• CPC Class Codes: B29L 2031/731 : Filamentary material, i.e. comprised of a single element, e.g. filaments, strands, threads, fibres cables B29L2031/707

Abstract

The invention relates to extracorporeal blood circuits, and components thereof (e.g., hollow fiber membranes, potted bundles, and blood tubing), including 0.005% to 10% (w/w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofiltration, hemodialysis, hemodiafiltration, hemoconcentration, blood oxygenation, and related uses.

Claims

1. A blood tubing comprising a base polymer admixed with from 0.005% to 10% (w/w) surface modifying macromolecule, wherein said blood tubing is antithrombogenic when contacted with blood, as measured by y-count, and wherein said surface modifying macromolecule is described by formula:

F_T—

[B-(Oligo)]_n-B—

F_T, 

 

(VII)

wherein

(i) Oligo is polypropylene oxide having a theoretical molecular weight of from 500 to 2,000 Daltons;

(ii) B is a hard segment formed from hexamethylene diisocyanate;

(iii) F_T is a polyfluoroorgano group; and

(iv) n is an integer from 1 to 10.

2. The blood tubing of claim 1, wherein said base polymer comprises polyvinyl chloride.

3. The blood tubing of claim 1, wherein n is an integer from 1 to 3.

4. The blood tubing of claim 1, wherein F_T is a polyfluoroalkyl having a theoretical molecular weight of between 100-1,500 Da.

5. The blood tubing of claim 1, wherein F_T is CF₃(CF₂)_rCH₂CH₂—

, wherein r is 2-20.

6. The blood tubing of claim 1, wherein F_T is CF₃(CF₂)_s(CH₂CH₂O)_x—

, wherein _X is 1-10 and s is 1-20.

7. The blood tubing of claim 1, wherein F_T is CH_mF₍₃₋

m)(CF₂)_rCH₂CH₂—

or CH_mF<sub>(3−

m)</sub>(CF₂)_s(CH₂CH₂O)_x—

, wherein m is 0, 1, 2, or 3;

_X is an integer between 1-10;

r is an integer between 2-20; and

s is an integer between 1-20.

8. The blood tubing of claim 1, wherein F_T is formed from 1H,1H,2H,2H-perfluoro-1-decanol;

1H,1H,2H,2H-perfluoro-1-octanol;

1H,1H,5H-perfluoro-1-pentanol;

or 1H,1H, perfluoro-1-butanol, or a mixture thereof.

9. The blood tubing of claim 8, wherein F_T is formed from 1H,1H,2H,2H-perfluoro-1-octanol.

10. The blood tubing of claim 1, wherein F_T is (CF₃)(CF₂)₅CH₂CH₂O—

, (CF₃)(CF₂)₇CH₂CH₂O—

, (CF₃)(CF₂)₅CH₂CH₂O—

, CHF₂(CF₂)₃CH₂O—

, or (CF₃)(CF₂)₂CH₂O—

.

11. The blood tubing of claim 1, wherein said surface modifying macromolecule is described by formula:

12. The blood tubing of claim 11, wherein the [CH(CH₃)CH₂O]_n unit has Mw of 1000 g/mol.