No- and H2S-releasing compounds
First Claim
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1. A method of treating an inflammatory disease, comprising administering to a subject in need thereof an effective amount of a compound of formula (Ia):
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Abstract
This disclosure relates to novel compounds containing an H2S releasing moiety and a nitric oxide (NO) releasing moiety covalently linked with a core (e.g., a salicylic acid moiety) and the use of such compounds in treating inflammatory diseases, including cancers. Therapeutic potency of these compounds is significantly higher than NSAIDs containing a H2S-releasing moiety alone (HS-NSAIDs) and NSAID containing a NO-releasing moiety alone (NO-NSAIDs). The compounds, in addition, exhibit reduced side effect, e.g., reduced stomach ulcers, upon administration.
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Citations
5 Claims
- 1. A method of treating an inflammatory disease, comprising administering to a subject in need thereof an effective amount of a compound of formula (Ia):
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3. A pharmaceutical composition comprising a compound according to formula (Ia) and a pharmaceutically acceptable excipient, wherein formula (Ia) is represented by the following:
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4. A compound of formula (Ia):
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5. A compound having the formula:
Specification