Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
First Claim
1. 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one in crystalline Form II, wherein the crystalline Form II has an X-ray powder diffraction (XRPD) pattern with peaks at about 8.44, 10.57, 14.92, 17.22, 21.26 and 22.42±
- 0.2 degrees two theta, or 10.47, 8.36, 5.93, 5.15, 4.18 and 3.96±
0.2 Å
in d-spacing.
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Accused Products
Abstract
Described herein are certain crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one, as well as pharmaceutical compositions employing the crystalline forms. Also provided are particles (e.g., nanoparticles) comprising such crystalline forms or pharmaceutical compositions. In certain examples, the particles are mucus penetrating particles (MPPs). Also described are methods of treating and/or preventing diseases using the crystalline forms or pharmaceutical compositions described herein.
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Citations
16 Claims
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1. 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one in crystalline Form II, wherein the crystalline Form II has an X-ray powder diffraction (XRPD) pattern with peaks at about 8.44, 10.57, 14.92, 17.22, 21.26 and 22.42±
- 0.2 degrees two theta, or 10.47, 8.36, 5.93, 5.15, 4.18 and 3.96±
0.2 Å
in d-spacing. - View Dependent Claims (2, 5, 7, 8, 9, 13, 15)
- 0.2 degrees two theta, or 10.47, 8.36, 5.93, 5.15, 4.18 and 3.96±
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3. 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one in crystalline Form III, wherein the crystalline Form III has an X-Ray Powder Diffraction (XRPD) pattern with peaks at about 9.60, 10.45, 19.30, 19.71, 21.84, and 23.42±
- 0.2 degrees two theta or 9.21, 8.46, 4.60, 4.50, 4.07 and 3.80±
0.2 Å
in d-spacing. - View Dependent Claims (4, 6, 10, 11, 12, 14, 16)
- 0.2 degrees two theta or 9.21, 8.46, 4.60, 4.50, 4.07 and 3.80±
Specification