Polymer particles

• US 9,688,788 B2
• Filed: 11/07/2014
• Issued: 06/27/2017
• Est. Priority Date: 11/08/2013
• Status: Active Grant

• Current Assignee: Terumo Corporation
• Original Assignee: Terumo Corporation
• Inventors: Cruise, Gregory M., Keeley, Edward Michael, Yu, Renee, Harris, Clayton, Plotkin, Steve
• Primary Examiner(s): KILIMAN, LESZEK B
• Application Number:
  US14/536,394
• Publication Number:
  US 20150166696A1
• Time in Patent Office: 963 Days
• Field of Search: 428402, 526217, 526234
• CPC Class Codes: A61K 31/704 attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin digitoxin A61K31/7048
• CPC Class Codes: A61K 47/32 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers , poly(meth)acrylates, or polyvinyl pyrrolidone
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/146 with organic macromolecular compounds
• CPC Class Codes: A61K 9/5026 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61L 2300/418 Agents promoting blood coagulation, blood-clotting agents, embolising agents
• CPC Class Codes: A61L 24/0015 Medicaments; Biocides
• CPC Class Codes: A61L 24/06 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L24/043, A61L24/046 take precedence
• CPC Class Codes: C08F 16/06 Polyvinyl alcohol ; Vinyl alcohol
• CPC Class Codes: C08F 20/28 containing no aromatic rings in the alcohol moiety
• CPC Class Codes: C08F 20/38 Esters containing sulfur
• CPC Class Codes: C08F 20/56 Acrylamide; Methacrylamide
• CPC Class Codes: C08F 22/385 Monomers containing two or more (meth)acrylamide groups, e.g. N,N'-methylenebisacrylamide
• CPC Class Codes: C08F 220/10 Esters
• CPC Class Codes: C08F 220/20 of polyhydric alcohols or phenols , e.g. 2-hydroxyethyl (meth)acrylate or glycerol mono-(meth)acrylate
• CPC Class Codes: C08F 220/28 containing no aromatic rings in the alcohol moiety
• CPC Class Codes: C08F 220/282 and containing two or more oxygen atoms
• CPC Class Codes: C08F 220/38 Esters containing sulfur
• CPC Class Codes: C08F 220/382 and containing oxygen, e.g. 2-sulfoethyl (meth)acrylate
• CPC Class Codes: C08F 290/062 Polyethers
• CPC Class Codes: C08G 65/33324 : acyclic
• CPC Class Codes: Y10T 428/2982 : Particulate matter [e.g., sphere, flake, etc.]

Abstract

Polymer particle embolics and methods of making same are described. The particle embolics can be used as embolization agents.

Claims

1. A method of making a spherical polymer particle comprising:

reacting an aqueous based prepolymer solution including at least one derivatized polyether macromer and an initiator in an oil to form the spherical polymer particle;

wherein said spherical polymer particle has a diameter less than about 1,200 μ

m.

2. The method of claim 1, wherein the oil is a mineral oil.

3. The method of claim 1, wherein the initiator is ammonium persulfate, tetramethylethylene diamine, or a combination thereof.

4. The method of claim 1, wherein the polymer particle has a diameter between about 40 μ

m and about 1,200 μ

m.

5. The method of claim 1, wherein the at least one derivatized polyether macromer is a derivative of poly(ethylene glycol), poly(propylene glycol), poly(tetramethylene oxide), or a combination thereof.

6. The method of claim 5, wherein the at least one derivatized polyether macromer is poly(ethylene glycol) diacrylamide, poly(ethylene glycol) diacrylate, poly(ethylene glycol) dimethacrylate, poly(ethylene glycol) dimethacrylamide, or a combination thereof.

7. The method of claim 5, wherein the at least one derivatized polyether macromer is poly(ethylene glycol) diacrylamide 10,000.

8. The method of claim 1, further comprising at least one monomer.

9. The method of claim 8, wherein the at least one monomer is glycerol monomethacrylate, amino ethyl methacrylate, 3-sulfopropyl acrylate, amino propyl methacrylamide, or a combination thereof.

10. The method of claim 8, wherein the monomer is not n-isopropyl acrylamide.