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Polymers for functional particles

  • US 9,688,812 B2
  • Filed: 02/13/2015
  • Issued: 06/27/2017
  • Est. Priority Date: 05/15/2006
  • Status: Active Grant
First Claim
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1. A method of making particles, comprising:

  • providing a solution comprising(i) a first population of an amphiphilic macromolecule comprising a biocompatible hydrophobic polymer at one end and a biocompatible hydrophilic polymer at the other end, and(ii) a second population of a second macromolecule comprising a biocompatible hydrophobic polymer;

    wherein one or more of the first or second macromolecule further comprises a moiety selected from the group consisting of a targeting moiety, an imaging moiety, a chelating moiety, a moiety having multiple charge groups, and a therapeutic moiety; and

    contacting the solution with a polymer nonsolvent for the macromolecules under conditions wherein the macromolecules orient to form particles having hydrophobic polymer ends of the amphiphilic macromolecule on the inside of the particles and hydrophilic polymer ends of the amphiphilic macromolecules on the surface of the particles,wherein the ratio between the first population of the amphiphilic macromolecule and the second population of the second macromolecule is controlled to form particles with a specific surface density of moieties.

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