Conductivity measurement cell
First Claim
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1. A conductivity measurement system comprising:
- a test strip having a body, a sample container, a reference chamber, and a plurality of electrodes; and
a measurement component coupled to the electrodes and configured to obtain a plurality of conductance measurements, wherein;
the sample container and the reference chamber are separated by a coincident membrane, the coincident membrane having two opposed sides, one side in contact with the sample container and the other side in contact with the reference chamber, andthe measurement component is coupled to the sample container, the reference chamber, and the electrodes, and configured to;
based on the plurality of conductance measurements, provide a determination that a temperature of the sample container and a temperature of the reference chamber are substantially the same and,based on the determination, derive a corrected amount or concentration of an analyte in a sample situated in the sample chamber.
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Abstract
The application relates to a conductivity measurement cell for measuring the concentration of a preselected biomarker or analyte in a body fluid, such as urine. In order to reduce the effect of sample dilution on measured concentration, the measured concentration can be normalized by a dilution factor, which can be determined from electrical conductivity. A test strip and measurement apparatus is disclosed for performing such normalized concentration measurement.
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Citations
15 Claims
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1. A conductivity measurement system comprising:
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a test strip having a body, a sample container, a reference chamber, and a plurality of electrodes; and a measurement component coupled to the electrodes and configured to obtain a plurality of conductance measurements, wherein; the sample container and the reference chamber are separated by a coincident membrane, the coincident membrane having two opposed sides, one side in contact with the sample container and the other side in contact with the reference chamber, and the measurement component is coupled to the sample container, the reference chamber, and the electrodes, and configured to; based on the plurality of conductance measurements, provide a determination that a temperature of the sample container and a temperature of the reference chamber are substantially the same and, based on the determination, derive a corrected amount or concentration of an analyte in a sample situated in the sample chamber. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 13)
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11. A conductivity measurement system comprising:
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a conductivity measurement test strip having a body, a sample container and a reference chamber, the sample container and the reference chamber separated by a coincident membrane, the coincident membrane having two opposed sides, one side in contact with the sample container and the other side in contact with the reference chamber; a measurement component having a first node and a second node, wherein the test strip is configured for use with the measurement component for deriving a temperature corrected measure of electrical conductivity of a sample, and wherein the measurement component is configured to provide; a measurement of a first, inherent conductance of the measurement component; a measurement of a second conductance when a reference is connected electrically to the measurement component between the first node and the second node; a measurement of a third conductance when a sample is connected electrically to the measurement component; and
further configured to;provide a determination that a temperature of the sample container and a temperature of the reference chamber are substantially the same by combining the first, second and third conductance measurements; and
,based on the determination, derive a corrected amount or concentration of an analyte in the sample.
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12. A method, comprising:
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measuring a plurality of conductances using a conductivity measurement system comprising; a test trip having a body, a sample container and a reference chamber, the sample container and the reference chamber separated by a coincident membrane, the coincident membrane having two opposed sides, one side in contact with the sample container and the other side in contact with the reference chamber, and a measurement component; based on the plurality of conductance measurements, providing a determination that a temperature of the sample container and a temperature of the reference chamber are substantially the same; and based on the determination, deriving a corrected amount or concentration of an analyte in the sample.
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14. A device for deriving a corrected amount or concentration of an analyte in a sample, comprising:
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a conductivity measurement test strip having a body, a sample container, a reference chamber, the sample container and the reference chamber separated by a coincident membrane, the coincident membrane having two opposed sides, one side in contact with the sample container and the other side in contact with the reference chamber; and a measurement component switchably electrically coupled to the sample container and the reference chamber and configured to measure a plurality of conductances, wherein the plurality of measured conductances are used to provide a determination that a temperature of the sample container and a temperature of the reference chamber are substantially the same, and configured to, based on the determination, derive a corrected amount or concentration of an analyte in the sample. - View Dependent Claims (15)
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Specification