Temperature sensing analyte sensors, systems, and methods of manufacturing and using same

• US 9,689,832 B2
• Filed: 10/13/2015
• Issued: 06/27/2017
• Est. Priority Date: 11/12/2010
• Status: Active Grant

• Current Assignee: Ascensia Diabetes Care Holdings AG (PHC Holdings Corporation)
• Original Assignee: Ascensia Diabetes Care Holdings AG (PHC Holdings Corporation)
• Inventors: Creaven, John P., Wu, Mu, Charlton, Steven C., Sun, Hoi-Cheong Steve, Ripley, Paul M.
• Primary Examiner(s): LARKIN, DANIEL SEAN
• Application Number:
  US14/882,419
• Publication Number:
  US 20160033442A1
• Time in Patent Office: 623 Days
• CPC Class Codes: A61B 2560/0252 using ambient temperature
• CPC Class Codes: A61B 2560/0285 Apparatus for single use
• CPC Class Codes: A61B 2562/12 Manufacturing methods specially adapted for producing sensors for in-vivo measurements
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: C12Q 1/001 Enzyme electrodes
• CPC Class Codes: G01K 13/00 Thermometers specially adapted for specific purposes
• CPC Class Codes: G01K 7/02 using thermoelectric elements, e.g. thermocouples
• CPC Class Codes: G01N 25/00 Investigating or analyzing materials by the use of thermal means G01N3/00 - G01N23/00 take precedence
• CPC Class Codes: G01N 27/3272 Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels optical biosensors G01N33/52
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771
• CPC Class Codes: Y10T 29/49117 Conductor or circuit manufacturing

Abstract

In some aspects, an analyte sensor is provided for detecting an analyte concentration level in a bio-fluid sample. The analyte sensor has a base, a first electrode and a second electrode wherein a thermocouple portion is provided integral with the second electrode thereby enabling on-sensor temperature measurement capability. In some embodiments, two and only two electrical contact engagement portions are provided thereby simplifying electrical contact. Manufacturing methods and systems utilizing the analyte sensors are provided, as are numerous other aspects.

Claims

1. An analyte sensor, comprising:

a first electrode having a contact engagement portion and a sensing portion;

a second electrode having a contact engagement portion and a sensing portion;

an active region provided in contact with, and extending between, the sensing portions of the first electrode and the second electrode; and

a thermocouple portion comprising at least part of a conducting path from the active region to the contact engagement portion of the second electrode.

2. The analyte sensor of claim 1, wherein the first electrode comprises a working electrode, and the second electrode comprises a counter or reference electrode.

3. The analyte sensor of claim 1, wherein the contact engagement portions are the only two contact engagement portions of the analyte sensor.

4. The analyte sensor of claim 1, further comprising a base, the first electrode and the second electrode extending along the base.

5. The analyte sensor of claim 1, wherein the first electrode comprises a different conductive material than the thermocouple portion of the second electrode.

6. The analyte sensor of claim 1, wherein the thermocouple portion comprises a carbon-based material.

7. The analyte sensor of claim 4, wherein the first electrode comprises a noble metal and the thermocouple portion comprises a carbon-based material.

8. The analyte sensor of claim 1, further comprising a fuse member extending between the first electrode and the second electrode.

9. The analyte sensor of claim 8, wherein the fuse member is manufactured from the same material as the first electrode.

10. The analyte sensor of claim 8, wherein the fuse member has a burn value that is less than 250 mV.

11. The analyte sensor of claim 8, wherein the fuse member has a burn value that is less than a constant voltage bias adapted to be received across the active region during an analyte measurement test.

12. The analyte sensor of claim 8, wherein the thermocouple portion comprises a carbon trace extending from a reference junction at the contact engagement portion of the second electrode and a sensing junction adjacent to the fuse member.