Ocular surface interferometry (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film

• US 9,693,682 B2
• Filed: 06/09/2014
• Issued: 07/04/2017
• Est. Priority Date: 04/01/2009
• Status: Active Grant

• Current Assignee: TearScience Inc. (Johnson & Johnson)
• Original Assignee: TearScience Inc. (Johnson & Johnson)
• Inventors: Korb, Donald R., Gravely, Benjamin T., Grenon, Stephen M., Weber, William L., Chinnock, Randal B.
• Primary Examiner(s): PINKNEY, DAWAYNE
• Application Number:
  US14/299,504
• Publication Number:
  US 20140285767A1
• Time in Patent Office: 1,121 Days
• Field of Search: 351206, 351200, 351205, 351209-210, 351221-223, 351245-246, 351212, 351208, 351160 R, 351159, 351247
• CPC Class Codes: A61B 3/0025 characterised by electronic signal processing, e.g. eye models
• CPC Class Codes: A61B 3/0041 characterised by display arrangements
• CPC Class Codes: A61B 3/1005 for measuring distances inside the eye, e.g. thickness of the cornea A61B3/11 takes precedence
• CPC Class Codes: A61B 3/101 for examining the tear film
• CPC Class Codes: A61B 3/14 Arrangements specially adapted for eye photography apparatus or arrangements for taking photographs per se G03B
• CPC Class Codes: G06T 2207/30041 Eye; Retina; Ophthalmic
• CPC Class Codes: G06T 7/0012 Biomedical image inspection

Abstract

Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image. The resulting image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).

Claims

1. An apparatus for measuring a tear film layer thickness (TFLT) of an ocular tear film, comprising:

a control system configured to;

(a) receive at least one first image containing optical wave interference of specularly reflected light and a background signal from a region of interest of an ocular tear film captured by an imaging device while illuminated by a multi-wavelength light source;

(b) detect whether an eyelid blink was captured by the imaging device in the at least one first image;

(c) remove any images in the at least one first image on which the eyelid blink was detected to produce at least one resulting image;

(d) convert at least a portion of the at least one resulting image representing the optical wave interference of specularly reflected light from at least a portion of the region of interest of the ocular tear film into at least one color-based value;

(e) compare the at least one color-based value to a tear film layer optical wave interference model; and

(f) measure a TFLT of the at least a portion of the region of interest of the ocular tear film based on the comparison of the at least one color-based value to the tear film layer optical wave interference model.

2. The apparatus of claim 1, wherein the control system is configured to detect whether a partial eyelid blink was captured by the imaging device in the at least one first image.

3. The apparatus of claim 1, wherein the control system is configured to detect whether a full eyelid blink was captured by the imaging device in the at least one first image.

4. The apparatus of claim 1, wherein the control system is further configured to:

(g) receive at least one second image containing a background signal from the region of interest of the ocular tear film captured by the imaging device; and

(h) subtract the at least one second image from the at least one first image to generate the at least one resulting image containing the optical wave interference of specularly reflected light from the region of interest of the ocular tear film with the background signal removed or reduced.

5. The apparatus of claim 4, wherein the control system is further configured to:

detect whether an eyelid blink was captured by the imaging device in the at least one second image; and

remove any images in the at least one second image on which the eyelid blink was detected.

6. The apparatus of claim 1, wherein the tear film layer optical wave interference model is comprised of a theoretical tear film layer optical wave interference model.

7. The apparatus of claim 1, wherein the control system is further configured to apply a threshold function to the at least one resulting image.

8. The apparatus of claim 1, wherein the control system is further configured to apply at least one of a spatial erode function and a dilate function to the at least one resulting image.

9. The apparatus of claim 4, wherein the control system is further configured to sequentially repeat step (a) to receive a plurality of first images and step (g) to receive a plurality of second images interleaved with the plurality of first images to provide a plurality of first and second image pairs.

10. The apparatus of claim 9, wherein the control system is configured to subtract the plurality of second images from the plurality of first and second image pairs from the corresponding plurality of first images from the plurality of first and second image pairs to generate a plurality of resulting images each containing the optical wave interference of specularly reflected light from the region of interest of the ocular tear film with the background signal removed or reduced.

11. The apparatus of claim 1, wherein the control system is configured to detect whether the eyelid blink was captured by the imaging device in the at least one first image based on a function of an intensity of the at least one resulting image.

12. The apparatus of claim 1, wherein the control system is configured to detect whether the eyelid blink was captured by the imaging device in the at least one first image by being configured to detect a pupil in the at least one first image.

13. The apparatus of claim 1, wherein the control system is further configured to adjust the at least one color-based value in the at least one resulting image based on the International Colour Consortium (ICC).

14. The apparatus of claim 1, wherein the control system is further configured to subtract an offset from the at least one resulting image.

15. The apparatus of claim 1, wherein the at least one color-based value is comprised of at least one red-green-blue (RGB) component value.

16. The apparatus of claim 1, wherein the control system is configured to compare the at least one color-based value to the tear film layer optical wave interference model by being configured to determine a closest matching entry in the tear film layer optical wave interference model to the at least one color-based value.

17. The apparatus of claim 16, wherein the control system is configured to determine the closest matching entry by being configured to determine a closest distance between the at least one color-based value to a color-based value in the tear film layer optical wave interference model.

18. The apparatus of claim 1, wherein the control system is configured to measure the TFLT of the at least a portion of the region of interest of the ocular tear film based on the comparison of the at least one color-based value to the tear film layer optical wave interference model by being configured to measure at least one of a lipid layer thickness (LLT) and an aqueous layer thickness (ALT).

19. The apparatus of claim 1, wherein the tear film layer optical wave interference model is comprised of a plurality of color-based values each corresponding to at least one of a lipid layer thickness (LLT) and an aqueous layer thickness (ALT).

20. The apparatus of claim 1, wherein the tear film layer optical wave interference model is limited to a plurality of color-based values that do not exceed a representation of 240 nanometers (nm) of lipid layer thickness (LLT).

21. The apparatus of claim 1, wherein the tear film layer optical wave interference model is comprised of at least two dimensions comprised of a first dimension containing a plurality of color-based values each corresponding to a lipid layer thickness (LLT), and a second dimension containing a plurality of color-based values each corresponding to an aqueous layer thickness (ALT).

22. The apparatus of claim 1, wherein the tear film layer optical wave interference model is a model comprised from the group consisting of a 2-wave tear film layer optical wave interference model and a 3-wave tear film layer optical wave interference model.

23. The apparatus of claim 1, wherein the at least a portion of the at least one resulting image representing the optical wave interference of specularly reflected light from the at least a portion of the region of interest of the ocular tear film represents a pixel in the at least one resulting image.

24. The apparatus of claim 1, wherein the at least one color-based value is comprised of a plurality of color-based values representing the optical wave interference of specularly reflected light from a plurality of portions of the region of interest of the ocular tear film.

25. The apparatus of claim 24, wherein the control system is configured to:

compare each of the plurality of color-based values to the tear film layer optical wave interference model; and

measure the TFLT for each of the plurality of color-based values based on the comparison of each of the plurality of color-based values to the tear film layer optical wave interference model.

26. The apparatus of claim 25, wherein the control system is further configured to average the comparison of each of the plurality of color-based values to the tear film layer optical wave interference model.

27. The apparatus of claim 25, wherein the control system is further configured to measure the TFLT by determining closest matching color-based entries between each of the plurality of color-based values to color-based values in the tear film layer optical wave interference model.

28. The apparatus of claim 1, further comprising the multi-wavelength light source configured to illuminate the region of interest of the ocular tear film with multi-wavelength light.

29. The apparatus of claim 28, wherein the multi-wavelength light source is comprised of a multi-wavelength Lambertian light source configured to uniformly or substantially uniformly illuminate the region of interest of the ocular tear film.

30. The apparatus of claim 4, further comprising the imaging device configured to capture the optical wave interference of specularly reflected light and the background signal from the region of interest of the ocular tear film while illuminated by the multi-wavelength light source in the at least one first image, and capture the background signal from the region of interest of the ocular tear film in the at least one second image.