Sampling and dispensing device

• US 9,694,358 B2
• Filed: 03/27/2009
• Issued: 07/04/2017
• Est. Priority Date: 03/28/2008
• Status: Active Grant

• Current Assignee: Orion Diagnostica Oy
• Original Assignee: Orion Diagnostica Oy
• Inventors: Luotola, Juhani
• Primary Examiner(s): DOUGHERTY, SEAN PATRICK
• Application Number:
  US12/935,078
• Publication Number:
  US 20110020195A1
• Time in Patent Office: 3,021 Days
• Field of Search: 600573, 600577, 600578, 600583, 600584, 604122, 422512
• CPC Class Codes: A61B 10/0045 Devices for taking samples of body liquids devices for taking blood samples A61B5/15
• CPC Class Codes: A61B 10/0051 for taking saliva or sputum samples devices for receiving spittle A61J9/00
• CPC Class Codes: A61B 2010/0067 Tear or lachrymal fluid
• CPC Class Codes: A61B 5/150022 for capillary blood or interstitial fluid
• CPC Class Codes: A61B 5/150213 Venting means
• CPC Class Codes: A61B 5/150236 Pistons, i.e. cylindrical bodies that sit inside the syringe barrel, typically with an air tight seal, and slide in the barrel to create a vacuum or to expel blood
• CPC Class Codes: A61B 5/150244 Rods for actuating or driving the piston, i.e. the cylindrical body that sits inside the syringe barrel, typically with an air tight seal, and slides in the barrel to create a vacuum or to expel blood
• CPC Class Codes: A61B 5/150251 Collection chamber divided into at least two compartments, e.g. for division of samples injection syringes having more than one chamber A61M5/19; syringes for injection of two or more media A61M5/2448, A61M5/284; sample preparation for further analysis A61B5/150755
• CPC Class Codes: A61B 5/150343 Collection vessels for collecting blood samples from the skin surface, e.g. test tubes, cuvettes sampling from within body cavities A61B5/150015, A61B5/150045
• CPC Class Codes: A61B 5/150351 Caps, stoppers or lids for sealing or closing a blood collection vessel or container, e.g. a test-tube or syringe barrel caps for bottles or containers in general B65D41/00
• CPC Class Codes: A61B 5/150755 Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
• CPC Class Codes: A61J 1/2093 Containers having several compartments for products to be mixed
• CPC Class Codes: A61M 5/283 by telescoping of ampoules or carpules with the syringe body
• CPC Class Codes: B01L 2300/044 pierceable, e.g. films, membranes
• CPC Class Codes: B01L 2300/0672 Integrated piercing tool
• CPC Class Codes: B01L 2400/0406 capillary forces
• CPC Class Codes: B01L 2400/0478 pistons
• CPC Class Codes: B01L 3/022 Capillary pipettes, i.e. having very small bore B01L3/0224 - B01L3/0237 take precedence
• CPC Class Codes: B01L 3/0282 mounted within a receptacle wash bottles B01L3/10

Abstract

The present invention relates to a device and method for easy collection, dilution, mixing and dispensing of a liquid specimen in a self-contained system. The present invention can be used in combination with numerous testing means for performing chemical, biochemical or biomedical qualitative or quantitative assays in the field of both clinical and hygiene testing.

Claims

1. A device comprising:

a container comprising an open end and a closed end;

a first penetrable member disposed within said container and cooperating with said container to form a first sealed chamber, said first penetrable member is movable within said container and operable as a piston within said container;

a sampler defining a passage for sampling a sample which is open at first and second ends, at least a portion of said passage extending from said first end comprising a capillary passage operable to draw said sample into said passage by capillary action, said sampler being movable relative to said container, said sampler comprising a penetrating means configured to penetrate said first penetrable member such that said passage is in communication with said first sealed chamber once said penetrable member has been penetrated.

2. The device according to claim 1 wherein said first penetrable member comprises a puncturable member and said penetrating means comprises a puncturing means configured to puncture said puncturable member.

3. The device according to claim 1 wherein said first penetrable member comprises a member having an aperture and said penetrating means comprises a plug, said plug being arranged to seal said aperture, wherein said plug is disposed at a distal end of said penetrating means such that moving said penetrating means into said penetrable member moves said plug into said chamber.

4. The device according to claim 1 wherein said first penetrable member comprises a member having an aperture extending entirely therethrough, the device further comprising a plug, said plug being arranged to seal said aperture, said penetrating means pushing said plug through said aperture and into said chamber.

5. The device according to claim 1 wherein said sampler is configured to slide inside said container.

6. The device according to claim 5 wherein said sampler comprises a protrusion configured to abut against said container and arranged to limit movement of said sampler into said container after moving said sampler into said container.

7. The device according to claim 5, wherein said sampler comprises a shaft or rod.

8. The device according to claim 1 wherein said sampler comprises an engagement means configured to engage with said penetrable member after said penetrating means penetrates said penetrable member.

9. The device according to claim 8 wherein said container is a cylinder in which said first penetrable member is slidable, said engagement means being configured to engage said first penetrable member to operate said first penetrable member as said piston.

10. The device according to claim 9 wherein said first penetrable member is operable to expel contents of said passage.

11. The device according to claim 10 wherein said first penetrable member is operable to expel said contents of said passage into said first sealed chamber.

12. The device according to claim 10 wherein said first penetrable member is operable to expel said contents of said passage from said first end.

13. The device according to claim 9 wherein said first penetrable member is operable to expel contents of said first sealed chamber through said passage.

14. The device according to claim 8 wherein said engagement means is spaced apart from said second end of said passage.

15. The device according to claim 8 wherein said engagement means is configured to operate said first penetrable member as said piston by pushing said first penetrable member.

16. The device according to claim 8 wherein said engagement means comprises a locking means configured to lock with said first penetrable member.

17. The device according to claim 16 wherein said locking means comprises a fluke, said first penetrable member being configured such that said sampler is unlocked from said first penetrable member by twisting.

18. The device according to claim 8 wherein said engagement means comprises a flange.

19. The device according to claim 8 wherein said engagement means comprises a catching means configured such that said catching means catches said penetrable member.

20. The device according to claim 19 wherein said catching means is configured to operate said first penetrable member as said piston by pulling said first penetrable member.

21. The device according to claim 19 wherein said catching means comprises a fluke.

22. The device according to claim 1 wherein a diameter of a portion of said passage extending from said second end of said passage is larger than a diameter of said capillary passage.

23. The device according to claim 1 wherein, adjacent to said capillary passage, a diameter of said hollow passage increases in a step fashion.

24. The device according to claim 1 wherein said first penetrable member is elastic and an end of said sampler is configured to form a seal with said first penetrable member after penetrating said first penetrable member.

25. The device according to claim 1, further comprising at least one ventilation opening disposed between an inside and an outside of said container and arranged to vent a space between said sampler and said first penetrable member.

26. The device according to claim 25 wherein said sampler comprises a flange spaced apart from an end of said sampler and configured to engage with said first penetrable member after said penetrating means penetrates said first penetrable member, said ventilation opening being arranged in said flange.

27. The device according to claim 1 further comprising a second sealed chamber bounded on at least one side by at least a second penetrable member configured to be penetrated by said penetrating means, said second sealed chamber being arranged in series with said first sealed chamber.

28. The device according to claim 1 wherein said penetrating means is formed by a rim of said passage.

29. The device according to claim 1 wherein said first penetrable member is formed in the shape of a cylinder having a closed end, an open end, and a wall arranged to abut against a wall of said container to allow said sampler to enter said first penetrable member through said open end.

30. The device according to claim 1 wherein said sampler stores dry reagents in said passage.

31. The device according to claim 1 wherein said first sealed chamber contains a reagent.

32. The device according to claim 1 wherein said device is a volumetric sampling and volumetric dispensing device.

33. The device according to claim 1 wherein said first sealed chamber contains a liquid.

34. The device according to claim 1 further comprising an auxiliary vessel.

35. The device according to claim 34 wherein said auxiliary vessel comprises one of a test tube, a cuvette, a cassette, a lateral-flow assay device, and a flow-through assay device.

36. A method of drawing and dispensing a sample using a device for drawing and dispensing said sample, the device comprising a container comprising a chamber bounded on at least one side by a penetrable member, said chamber comprising a fluid and said device comprising a sampler comprising a capillary passage extending from a first end of the sampler and a penetrating means at a second end of the sampler and, said method comprising:

drawing a sample of fluid by capillary action using said capillary passage; and

penetrating said penetrable member to engage said penetrable member and operate said penetrable member as a piston, wherein said piston is operated to expel said sample of fluid through said capillary passage.

37. The method according to claim 36 wherein said penetrable member comprises a puncturable member and said penetrating means comprises a puncturing means which punctures said puncturable member.

38. The method according to claim 36 wherein said penetrable member comprises a member having an aperture and said penetrating means comprises a plug, said plug being arranged to seal said aperture, wherein said plug is disposed at a distal end of said penetrating means such that moving said penetrating means into said penetrable member moves said plug into said chamber.

39. The method according to claim 36 wherein said penetrable member comprises a member having an aperture extending entirely therethrough, said device further comprising a plug, said plug being arranged to seal said aperture, said penetrating means pushing said plug through said aperture and into said chamber.

40. The method according to claim 36 wherein said sample comprises bodily fluids.

41. The method according to claim 40 wherein said bodily fluids comprise blood.

42. The method according to claim 36 wherein said fluid comprises a hygiene sample.

43. The method according to claim 36 wherein said piston is operated to expel said sample of fluid into said chamber.

44. The method according to claim 43 wherein said method further comprises:

mixing said sample with said fluid in said chamber; and

expelling said combined sample and fluid through said passage.

45. The method according to claim 36 wherein said fluid is expelled into an auxiliary vessel.

46. The method according to claim 36, further comprising at least one ventilation opening disposed between an inside and an outside of said container and arranged to vent a space between said sampler and said penetrable member.

47. The method according to claim 46 wherein said sampler comprises a flange spaced apart from an end of said sampler and configured to engage with said penetrable member after said penetrating means penetrates said penetrable member, said ventilation opening being arranged in said flange.

48. A kit of parts comprising:

a container comprising a sealed chamber bounded on at least one side by a penetrable member operable as a piston within said chamber; and

a sampler defining a passage which is open at both ends, at least a portion of a passage extending from a first end comprising a capillary passage operable to draw a sample of fluid into said passage by capillary action, the sampler comprising a penetrating means configured to penetrate said penetrable member such that said passage is in communication with said sealed chamber once said penetrable member has been penetrated.

49. The kit of parts according to claim 48 wherein said penetrable member comprises a puncturable member and said penetrating means comprises a puncturing means configured to puncture said puncturable member.

50. The kit of parts according to claim 48 wherein said penetrable member comprises a member having an aperture and said penetrating means comprises a plug, said plug being arranged to seal said aperture, wherein said plug is disposed at a distal end of said penetrating means such that moving said penetrating means into said penetrable member moves said plug into said chamber.

51. The kit of parts according to claim 48 wherein said penetrable member comprises a member having an aperture extending entirely therethrough, said device further comprising a plug, said plug being arranged to seal said aperture, said penetrating means pushing said plug through said aperture and into said chamber.

52. The kit of parts according to claim 48 further comprising an auxiliary vessel.

53. The kit of parts according to claim 48, wherein said penetrable member is movable relative to said sealed chamber and operable as a piston within said sealed chamber.

54. The kit of parts according to claim 48, further comprising at least one ventilation opening disposed between an inside and an outside of said container and arranged to vent a space between said sampler and said penetrable member.

55. The kit of parts according to claim 54 wherein said sampler comprises a flange spaced apart from an end of said sampler and configured to engage with said penetrable member after said penetrating means penetrates said penetrable member, said ventilation opening being arranged in said flange.