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Method for the synthesis of phosphorus atom modified nucleic acids

  • US 9,695,211 B2
  • Filed: 05/27/2016
  • Issued: 07/04/2017
  • Est. Priority Date: 12/02/2008
  • Status: Active Grant
First Claim
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1. A method for a synthesis of a nucleic acid comprising a chiral X-phosphonate moiety comprising:

  • reacting a molecule comprising an achiral H-phosphonate moiety, a chiral reagent, and a nucleoside comprising a 5′

    -OH moiety to form a condensed intermediate; and

    converting the condensed intermediate to the nucleic acid comprising a chiral X-phosphonate moiety;

    wherein;

    the nucleic acid comprising a chiral X-phosphonate moiety is a compound of Formula 1;

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