PDGF and VEGF aptamers having improved stability and their use in treating PDGF and VEGF mediated diseases and disorders
First Claim
Patent Images
1. A nucleic acid molecule comprising the nucleic sequence5′
- -C-G-A-C-A-G-C-A-Z-G-Z-A-Z-G-C-A-C-A-Z-C-Z-3′
(SEQ ID NO;
830),wherein z is a C-5 modified pyrimidine, and at least one of positions 4, 9, 10, 11 and 12 of the nucleic acid sequence comprise a phosphorothioate linkage or moiety, wherein position 1 is the first nucleoside starting from the 5′
-terminus of the nucleic acid sequence.
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Abstract
Aptamers having improved stability against nucleases that bind PDGF and aptamers that bind VEGF are provided. In addition, aptamer constructs comprising a PDGF aptamer and a VEGF aptamer are provided. Pharmaceutical compositions comprising the aptamers and aptamer constructs are provided, as well as methods of treating conditions using the aptamers and aptamer constructs.
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Citations
9 Claims
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1. A nucleic acid molecule comprising the nucleic sequence
5′ - -C-G-A-C-A-G-C-A-Z-G-Z-A-Z-G-C-A-C-A-Z-C-Z-3′
(SEQ ID NO;
830),wherein z is a C-5 modified pyrimidine, and at least one of positions 4, 9, 10, 11 and 12 of the nucleic acid sequence comprise a phosphorothioate linkage or moiety, wherein position 1 is the first nucleoside starting from the 5′
-terminus of the nucleic acid sequence. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- -C-G-A-C-A-G-C-A-Z-G-Z-A-Z-G-C-A-C-A-Z-C-Z-3′
Specification