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Multi-layered injectable self-assembling peptide scaffold hydrogels for long-term sustained release of human antibodies

  • US 9,700,521 B2
  • Filed: 03/14/2014
  • Issued: 07/11/2017
  • Est. Priority Date: 03/14/2013
  • Status: Active Grant
First Claim
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1. A sustained release formulation comprising;

  • (i) a gel core comprising a self-assembling first peptide and a therapeutic antibody, wherein the self-assembling first peptide has an amino acid sequence selected from the group consisting of Ac-(RADA)2-CONH2 (SEQ ID NO;

         1), Ac-(RADA)3-CONH2 (SEQ ID NO;

         2), Ac-(RADA)4-CONH2 (SEQ ID NO;

         3), and Ac-(RADA)5-CONH2 (SEQ ID NO;

         4); and

    ,(ii) a first layer encapsulating said gel core, wherein said first layer comprises a self-assembling second peptide, wherein the self-assembling second peptide has an amino acid sequence selected from the group consisting of Ac-(KLDL)3-CONH2 (SEQ ID NO;

         7), Ac-(KLDL)4-CONH2 (SEQ ID NO;

         8) and Ac-(KLDL)5-CONH2 (SEQ ID NO;

         9).

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