Probiotic compositions and methods

• US 9,700,586 B2
• Filed: 02/27/2013
• Issued: 07/11/2017
• Est. Priority Date: 02/28/2012
• Status: Active Grant

• Current Assignee: Cornell University
• Original Assignee: Cornell University
• Inventors: Oikonomou, Georgios, Teixeira, Andre Gustavo Vieira, Bicalho, Rodrigo Carvalho
• Primary Examiner(s): Afremova, Vera
• Application Number:
  US14/380,881
• Publication Number:
  US 20150044172A1
• Time in Patent Office: 1,595 Days
• Field of Search: None
• CPC Class Codes: A23K 10/18 of live microorganisms
• CPC Class Codes: A23K 50/10 for ruminants
• CPC Class Codes: A23K 50/20 for horses
• CPC Class Codes: A23K 50/30 for swines
• CPC Class Codes: A23K 50/60 for weanlings
• CPC Class Codes: A23K 50/75 for poultry
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/3204 Probiotics, living bacteria to be ingested for action in the digestive tract
• CPC Class Codes: A23V 2400/113 Acidophilus
• CPC Class Codes: A23V 2400/125 Casei
• CPC Class Codes: A23V 2400/157 Lactis
• CPC Class Codes: A23V 2400/169 Plantarum
• CPC Class Codes: A23V 2400/517 Bifidum
• CPC Class Codes: A23V 2400/533 Longum
• CPC Class Codes: A23V 2400/619 Jensenii
• CPC Class Codes: A61K 35/74 Bacteria therapeutic use of a bacterial protein A61K38/00
• CPC Class Codes: A61K 35/741 Probiotics probiotic yeast, e.g. saccharomyces A61K36/06
• CPC Class Codes: A61K 9/0053 Mouth and digestive tract, i.e. intraoral and peroral administration rectal administration A61K9/0031
• CPC Class Codes: C12Q 1/689 for bacteria
• CPC Class Codes: C12Q 2600/118 Prognosis of disease development

Abstract

The present invention relates to probiotic compositions and methods of using such compositions. In particular, the present invention provides method of using Faecalibacterium spp. to improve weight gain, provide prophylaxis against diarrhea and/or improve feed efficiency in an animal.

Claims

1. A method of improving weight gain, preventing diarrhea and/or improving feed efficiency in calves of less than two months of age comprising administering to said calves of less than two months of age a composition comprising one or more Faecalibacterium spp.

2. The method of claim 1, wherein said Faecalibacterium spp. is Faecalibacterium prausnitzii.

3. The method of claim 1, wherein said composition comprises one or more Faecalibacterium spp. in an amount effective to improve weight gain in said calves of less than two months of age.

4. The method of claim 1, wherein said composition comprises one or more Faecalibacterium spp. in an amount effective to provide prophylaxis against diarrhea in said calves of less than two months of age.

5. The method of claim 1, wherein said composition comprises one or more Faecalibacterium spp. in an amount effective to improve feed efficiency in said calves of less than two months of age.

6. The method of claim 1, wherein said composition is formulated as a powder, bolus, gel, drench, or capsule.

7. The method of claim 1, wherein said composition is provided as part of a milk replacer.

8. The method of claim 1, wherein said composition is coadministered with at least a second probiotic organism selected from the group consisting of Lactobacillus acidophilus, L. lactis, L. plantarum, L. casei, Bacillus subtilis, B. lichenformis, Enterococcus faecium, Bifidobacterium bifidum, B. longum, B. thermophilum, Propionibacterium jensenii, yeast, and combinations thereof.

9. The method of claim 1, wherein said composition is formulated with an additional additive selected from the group consisting of an energy substrate, a mineral, a vitamin, and combinations thereof.

10. A method of improving weight gain and/or improving feed efficiency in calves of less than two months of age comprising administering to said calves of less than two months of age a composition comprising one or more Faecalibacterium spp.

11. The method of claim 10, wherein said Faecalibacterium spp. is Faecalibacterium prausnitzii.

12. The method of claim 10, wherein said composition comprises one or more Faecalibacterium spp. in an amount effective to improve weight gain in said calves of less than two months of age.

13. The method of claim 10, wherein said composition comprises one or more Faecalibacterium spp. in an amount effective to improve feed efficiency in said calves of less than two months of age.

14. The method of claim 10, wherein said composition is formulated as a powder, bolus, gel, drench, or capsule.

15. The method of claim 10, wherein said composition is provided as part of a milk replacer.

16. The method of claim 10, wherein said composition is coadministered with at least a second probiotic organism selected from the group consisting of Lactobacillus acidophilus, L. lactis, L. plantarum, L. casei, Bacillus subtilis, B. lichenformis, Enterococcus faecium, Bifidobacterium bifidum, B. longum, B. thermophilum, Propionibacterium jensenii, yeast, and combinations thereof.

17. The method of claim 10, wherein said composition is formulated with an additional additive selected from the group consisting of an energy substrate, a mineral, a vitamin, and combinations thereof.