Device for extracorporeal blood treatment

• US 9,700,662 B2
• Filed: 04/29/2014
• Issued: 07/11/2017
• Est. Priority Date: 05/02/2013
• Status: Active Grant

• Current Assignee: B. Braun Avitum AG (B. Braun Holding GmbH & Co. KG)
• Original Assignee: B. Braun Avitum AG (B. Braun Holding GmbH & Co. KG)
• Inventors: Strohhoefer, Christof, Krause, Silvie, Ritter, Kai-Uwe, Meibaum, Joern
• Primary Examiner(s): DRODGE, JOSEPH W
• Application Number:
  US14/264,867
• Publication Number:
  US 20140326646A1
• Time in Patent Office: 1,169 Days
• Field of Search: 210 85, 210 90, 210 93, 210 962, 2103216, 21032171, 210646, 210647, 210637, 210739, 210741, 210745, 356 39- 42, 600310, 604 601, 604 609, 604 61
• CPC Class Codes: A61M 1/1609 after use, i.e. downstream of dialyser
• CPC Class Codes: A61M 1/1617 using measurements made during a temporary variation of a characteristic of the fresh dialysis fluid
• CPC Class Codes: A61M 2202/0498 Urea
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 2205/3313 used specific wavelengths
• CPC Class Codes: B01D 61/30 Accessories; Auxiliary operation
• CPC Class Codes: B01D 61/32 Controlling or regulating

Abstract

A device for extracorporeal blood treatment is disclosed that includes a detection equipment for detecting uremic toxins in a used dialysis liquid by measuring the absorbance, the detection equipment being provided at such a position downstream the outflow of the dialysis liquid from a filter element that at least one of the following requirements is fulfilled: a) the filling volume of the fluid line and of the components starting from the outflow of the used dialysis liquid from the filter element to the detection equipment is less than or equal to 100 ml; and b) the length of the fluid line starting from the outflow of the used dialysis liquid from the filter element to the detection equipment is at most 250 cm.

Claims

1. A device for extracorporeal blood treatment of blood of a patient, comprising:

a filter element which is subdivided into a blood-sided chamber and a dialysis liquid-side chamber and comprises an inflow for dialysis liquid to the dialysis liquid-side chamber and an outflow for the dialysis liquid from the dialysis liquid-side chamber,

a fluid line coupled to the outflow for the dialysis liquid, wherein the fluid line is configured to conduct used dialysis liquid from the dialysis liquid-side chamber via the outflow,

a bypass line selectively establishing a fluid connection between the inflow of the dialysis liquid-side chamber and the fluid line, the fluid connection bypassing the filter element, and a valve arranged on the fluid line downstream of the dialysis liquid-side chamber and upstream of the bypass line and further comprising

a detection equipment arranged on the fluid line downstream from the outflow of the dialysis liquid from the dialysis liquid-side chamber and between the valve and the dialysis liquid-side chamber, wherein the detection equipment is adapted to measure a concentration and/or concentration change of at least one metabolic product from the blood of the patient in the used dialysis liquid, and wherein the detection equipment is further configured to output measurement values corresponding to the measured concentration and/or concentration change of the at least one metabolic product,

wherein

the fluid line has a fixed internal filling volume starting from the outflow from the filter element and ending with the detection equipment, and

the detection equipment is arranged on the fluid line at a position downstream of the outflow of the dialysis liquid from the dialysis liquid-side chamber of the filter element, which position fulfills at least one of the following requirements;

a) the fixed internal filling volume of the fluid line is less than or equal to 100 ml;

or

b) the length of the fluid line starting from the outflow from the filter element to the detection equipment is at most 250 cm;

such that diffusive degeneration of the concentration and/or the concentration change of the at least one metabolic product, and/or temporal delay of measurements by the detecting equipment, is avoided.

2. The device for extracorporeal blood treatment according to claim 1, further comprising a device housing, the detection equipment being provided within the device housing and the filter element being arranged outside the device housing, the filter element being fluidly connected to the detection equipment via a housing feedthrough.

3. The device according to claim 2, wherein the detection equipment is disposed on the housing feedthrough at an inner side or an outer side of a wall of the device housing comprising the housing feedthrough.

4. The device for extracorporeal blood treatment according to claim 2, further comprising a pressure sensor which is arranged upstream of the detection equipment in the vicinity of the housing feedthrough.

5. The device for extracorporeal blood treatment according to claim 1, wherein an additional detection equipment is arranged on the fluid line downstream of the bypass line, in order to allow for a calibration of the additional detection equipment with fresh dialysis liquid when there is a bypass around the filter element.

6. The device for extracorporeal blood treatment according to claim 1, wherein an inner cross-section of the fluid line between the filter element and the detection equipment is between 3 mm and 7 mm.

7. The device for extracorporeal blood treatment according to claim 6, wherein the inner cross-section of the fluid line between the filter element and the detection equipment is substantially constant.

8. The device for extracorporeal blood treatment according to claim 6, wherein the inner cross-section of the fluid line between the filter element and the detection equipment is 5 mm.

9. The device for extracorporeal blood treatment according to claim 1, wherein the detection equipment comprises an optical sensor system in the form of a UV measuring device.

10. The device of claim 1, wherein the fixed internal filling volume is less than or equal to 30 ml.

11. The device of claim 1, wherein the length of the fluid line is less than or equal to 100 cm.

12. The device for extracorporeal blood treatment according to claim 1, further comprising fluidic components arranged on the fluid line starting from the outflow from the filter element and ending with the detection equipment, wherein the fixed internal filling volume of the fluid line including the arranged fluidic components is less than or equal to 100 ml.