Inhalation apparatus

• US 9,700,690 B2
• Filed: 06/12/2014
• Issued: 07/11/2017
• Est. Priority Date: 03/20/2002
• Status: Expired due to Term

• Current Assignee: Mannkind Corporation
• Original Assignee: Mannkind Corporation
• Inventors: Steiner, Solomon S., Poole, Trent
• Primary Examiner(s): Woodward, Valerie L
• Application Number:
  US14/303,173
• Publication Number:
  US 20140290654A1
• Time in Patent Office: 1,125 Days
• CPC Class Codes: A61K 9/14 Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles microspheres A61K9/16; microcapsules A61K9/50; nanocapsules, nanoparticles of the matrix type A61K9/51
• CPC Class Codes: A61M 15/0021 Mouthpieces therefor
• CPC Class Codes: A61M 15/0025 with caps
• CPC Class Codes: A61M 15/0028 using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
• CPC Class Codes: A61M 15/0093 without arming or cocking, e.g. acting directly on the delivery valve
• CPC Class Codes: A61M 15/06 Inhaling appliances shaped like cigars, cigarettes or pipes
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/12 with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 2206/16 Rotating swirling helical flow, e.g. by tangential inflows

Abstract

An inhaler is instantly activated upon its removal from a cover or cover unit, and by rotating a cartridge component of the inhaler with respect to a mouthpiece portion, so as to create a flow pathway for ambient air and particles. The cartridge component includes a chamber, whose contents typically include dry powders or the like. Upon creation of the flow pathway, the contents of the chamber are instantly accessible for immediate inhalation by a user through the mouthpiece portion.

Claims

1. An inhaler comprising a cartridge and a mouthpiece;

said cartridge comprising an assembly comprising a head portion and a tail portion;

wherein the head portion and the tail portion are joined together to form a chamber in the interior of the assembly and the head portion is configured to have an inlet conduit which provides access to the chamber;

said mouthpiece comprising a tube section comprising a shank having a port with a discharge tube for communicating with the chamber and an inlet opening separate from the discharge tube; and

wherein the mouthpiece is configured to be rotated relative to the cartridge thereby aligning the inlet opening and the inlet conduit providing an airflow pathway through the shank and into the chamber; and

wherein airflow from the inlet conduit is configured to de-agglomerate a dry powder within the chamber.

2. The inhaler of claim 1, further comprising a dry powder within the chamber.

3. The inhaler of claim 2, wherein the dry powder within the chamber comprises a bioactive molecule.

4. The inhaler of claim 2, wherein the dry powder comprises atropine, penicillin, doxycycline, ciproflaxin or a fluoroquinolone.

5. The inhaler of claim 4, wherein the dry powder further comprises a diketopiperazine.

6. The inhaler of claim 5 wherein the dry powder comprises atropine.

7. The inhaler of claim 5 wherein the dry powder comprises penicillin.

8. The inhaler of claim 5 wherein the dry powder comprises doxycycline.

9. The inhaler of claim 5 wherein the dry powder comprises ciproflaxin.

10. The inhaler of claim 5 wherein the dry powder comprises a fluoroquinolone.

11. The inhaler of claim 1, further comprising a cover configured to adapt to the mouthpiece.

12. The inhaler of claim 11, wherein the cover comprises a recess, a protrusion, or a finger grip groove.

13. The inhaler of claim 1, wherein the mouthpiece has a constant diameter portion which forms a straight air conduit and a tapered portion with an opening for abutting a user'"'"'s lips.

14. The inhaler of claim 13, wherein the tapered portion is at an angle of approximately 3 to 7 degrees diverging from the constant diameter portion.

15. The inhaler of claim 14, wherein the tapered portion has a cross-sectional aspect ratio of 2:

1.

16. The inhaler of claim 1 wherein the inlet opening is configured to allow ambient air into the chamber.

17. An inhaler comprising a cartridge and a mouthpiece;

said cartridge comprising an assembly comprising a head portion and a tail portion;

wherein the head portion and the tail portion are joined together to form a chamber in the interior of the assembly and the cartridge is configured to have an inlet conduit which provides access to the chamber;

wherein the mouthpiece includes a tube section including a port with a discharge tube for communicating with the chamber and wherein the mouthpiece includes an inlet opening separate from the discharge tube;

wherein the mouthpiece is configured to be rotated relative to the cartridge thereby aligning the inlet opening and the inlet conduit providing an airflow pathway through the shank and into the chamber; and

wherein airflow from the inlet conduit is configured to de-agglomerate a dry powder within the chamber.