Phenol crosslink for sensor membrane

• US 9,700,851 B2
• Filed: 05/13/2011
• Issued: 07/11/2017
• Est. Priority Date: 05/13/2010
• Status: Active Grant

• Current Assignee: Konamite Limited
• Original Assignee: WaveForm Technologies, Inc. (AgaMatrix Holdings LLC d/b/a WaveForm Diabetes)
• Inventors: Wang, Yuan, Gifford, Raeanne
• Primary Examiner(s): Kaucher, Mark
• Assistant Examiner(s): Hu, Henry
• Application Number:
  US13/107,816
• Publication Number:
  US 20120067734A1
• Time in Patent Office: 2,251 Days
• Field of Search: 205188, 528205
• CPC Class Codes: A61B 2562/12 Manufacturing methods specially adapted for producing sensors for in-vivo measurements
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: B01D 2323/30 Cross-linking
• CPC Class Codes: B01D 67/0006 by chemical reactions in-situ polymerisation, polycondensation, cross-linking or reaction for manufacturing composite membranes B01D69/125
• CPC Class Codes: B01D 71/72 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, not provided for in a single one of the groups B01D71/46 - B01D71/70 and B01D71/701 - B01D71/702
• CPC Class Codes: C12Q 1/003 Functionalisation
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771
• CPC Class Codes: G01N 27/40 Semi-permeable membranes or partitions

Abstract

Embodiments herein provide a membrane that is a product of a phenol crosslinked with one or more compounds containing an allyl group. The phenol may be electropolymerized with the allyl-containing compounds to form the crosslinked polymer. Suitable allyl-containing compounds include allylphenol, allylalcohol, allylamine, and allylcarbamide. A membrane may have one type of allyl-containing compound, or, alternatively, two or more types of compounds. As used in an analyte sensing device, a membrane formed from a crosslinked phenol may provide improved interference exclusion, peroxide response, stability, and/or solvent resistance.

Claims

1. An interference exclusion membrane, consisting essentially of phenol crosslinked by one or more of allylalcohol, allylamine, and allylcarbamide.

2. The membrane of claim 1, wherein the phenol is crosslinked by one of allylalcohol, allylamine, and allylcarbamide.

3. The membrane of claim 2, consisting essentially of phenol crosslinked by allylalcohol.

4. The membrane of claim 2, consisting essentially of phenol crosslinked by allylamine.

5. The membrane of claim 2, consisting essentially of phenol crosslinked by allylcarbamide.

6. The membrane of claim 1, wherein the phenol is crosslinked by two of allylalcohol, allylamine, and allylcarbamide.

7. An analyte sensor, comprising:

the interference exclusion membrane of claim 1; and

an electrically active electrode surface.

8. The analyte sensor of claim 7, wherein the interference exclusion membrane is disposed on the electrically active electrode surface.

9. The analyte sensor of claim 8, further comprising an enzyme layer disposed on the interference exclusion membrane.

10. The analyte sensor of claim 7, further comprising an enzyme layer disposed on the electrically active electrode surface, wherein the interference exclusion membrane is disposed on the enzyme layer.

11. The analyte sensor of claim 7, wherein the interference exclusion membrane is configured to provide interference exclusion, peroxide response, stability, and/or solvent resistance.