Substituted pyrazines as ATR kinase inhibitors
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Abstract
The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.
Certain compounds of this invention are of formula II, V, and/or VII:
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- wherein the variables are as defined herein.
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Citations
61 Claims
- 1. A compound of Formula II:
- 16. A pharmaceutical composition comprising a compound of formula II,
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17. A method of promoting cell death in cancer cells of a patient comprising administering to the patient a compound of formula II,
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18. A method of preventing cell repair from DNA damage in a patient comprising administering to the patient a compound of formula II,
- 19. A compound of Formula V:
- 39. A pharmaceutical composition comprising a compound of formula V,
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40. A method of promoting cell death in cancer cells of a patient comprising administering to the patient a compound of formula V,
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41. A method of preventing cell repair from DNA damage in a patient, comprising administering to the patient a compound of formula V,
- 42. A compound of Formula VII:
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53. A pharmaceutical composition comprising a compound of formula VII,
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54. A method of promoting cell death in cancer cells of a patient comprising administering to the patient a compound of formula VII,
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55. A method of preventing cell repair from DNA damage in a patient comprising administering to the patient a compound of formula VII,
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61. A compound selected from the group consisting of:
Specification