Gastrointestinal capsule and treatment method

• US 9,707,150 B2
• Filed: 08/17/2014
• Issued: 07/18/2017
• Est. Priority Date: 02/16/2012
• Status: Active Grant

• Current Assignee: Vibrant Ltd.
• Original Assignee: Vibrant Ltd.
• Inventors: Shabbat, Ronny
• Primary Examiner(s): Yu, Justine
• Assistant Examiner(s): GARBUS, DANIEL P
• Application Number:
  US14/461,414
• Publication Number:
  US 20150073315A1
• Time in Patent Office: 1,066 Days
• CPC Class Codes: A61B 1/00156 using self propulsion
• CPC Class Codes: A61H 21/00 Massage devices for cavities of the body , e.g. nose, ears and anus for the genitals A61H19/00; Vibration or percussion related aspects A61H23/00
• CPC Class Codes: A61H 2201/1207 with electric or magnetic drive
• CPC Class Codes: A61H 2201/149 rotation-linear or vice versa
• CPC Class Codes: A61H 2205/083 Abdomen
• CPC Class Codes: A61H 23/02 with electric or magnetic drive
• CPC Class Codes: A61H 23/0254 with rotary motor
• CPC Class Codes: A61H 23/0263 using rotating unbalanced masses

Abstract

A gastrointestinal capsule (GIC) including a capsule housing having a longitudinal axis; a thrusting mechanism, disposed within the housing; and a battery adapted to power the and a battery adapted to power the thrusting mechanism; the thrusting mechanism having an active mode, and a passive mode with respect to the active mode, the thrusting mechanism adapted to exert a radial force on the housing, in a radial direction with respect to the axis, such that when the capsule is disposed within a gastrointestinal tract of a user, and the mechanism is in the active mode, the gastrointestinal capsule stimulates a wall of the tract; the active mode including a series of at least two pulses of the radial force, the series having a first duration, the passive mode having a second duration, wherein an activation cycle is defined by the series of pulses followed by the second duration.

Claims

1. A gastrointestinal capsule (GIC) comprising:

(a) a capsule housing having a longitudinal axis;

(b) a thrusting mechanism, disposed within said capsule housing, said thrusting mechanism having an active mode, and a passive mode with respect to said active mode,

said thrusting mechanism including;

(i) a rotatably mounted eccentric weight,

said thrusting mechanism adapted, in said active mode, to rotate said eccentric weight thereby to exert radial forces on said capsule housing, in a radial direction with respect to said longitudinal axis, and

(ii) an axial perturbation arrangement including;

a motor;

a motor shaft, disposed at least partially in a direction along said longitudinal axis, said motor shaft operatively connected to, and driven by, said motor; and

a thrusting weight associated with said motor shaft,

said axial perturbation arrangement adapted to at least periodically urge said thrusting weight along said motor shaft, to deliver axial forces to said capsule housing,

such that when the gastrointestinal capsule is disposed within a gastrointestinal tract of a user, and said thrusting mechanism is in said active mode, the gastrointestinal capsule stimulates a wall of said gastrointestinal tract; and

(c) a battery adapted to power said thrusting mechanism.

2. The GIC of claim 1, wherein:

said active mode includes a series of at least two pulses of said radial forces, said series having a first duration;

said passive mode has a second duration;

an activation cycle is defined by said series of pulses followed by said second duration;

said first duration is within a range of 1-10 seconds; and

said second duration exceeds said first duration.

3. The GIC of claim 2, said activation cycle having a period within a range of 5-60 seconds.

4. The GIC of claim 2, said activation cycle having a period within a range of 8-30 seconds.

5. The GIC of claim 2, said thrusting mechanism configured such that said first duration is within a range of 2.5-6 seconds.

6. The GIC of claim 1, said thrusting mechanism configured to exert said radial forces on said capsule housing to attain a vibrational frequency within a range of 12 Hz to 80 Hz.

7. The GIC of claim 6, said thrusting mechanism configured such that said vibrational frequency is within a range of 15 Hz to 50 Hz.

8. The GIC of claim 6, said thrusting mechanism configured such that said vibrational frequency is within a range of 18 Hz to 45 Hz.

9. The GIC of claim 1, said thrusting mechanism configured such that a net force exerted by the gastrointestinal capsule on an external environment thereof is in the range of 400-600 grams force.

10. The GIC of claim 1, said thrusting mechanism configured such that an instantaneous net force exerted by the gastrointestinal capsule on an external environment thereof is in the range of 800-1500 grams force.

11. The GIC of claim 1, said thrusting mechanism including a controller, electrically attached to said battery, said controller adapted to control said thrusting mechanism.

12. The GIC of claim 1, wherein a ratio of said radial forces to said axial forces is at least 1.5:

1.

13. The GIC of claim 12, said ratio of said radial forces to said axial forces being at most 20:

1.

14. The GIC of claim 12, said ratio of said radial forces to said axial forces being within a range of 2.5:

1 to 15;

1.

15. The gastrointestinal capsule of claim 1, said axial perturbation arrangement further including a stopper or cap, adapted to receive a distal end of said motor shaft, said stopper or cap impinging against an inner wall of said capsule housing.

16. The gastrointestinal capsule of claim 1, said axial perturbation arrangement further including a spring associated with said motor shaft,

said axial perturbation arrangement adapted such that, in a first state, said spring is compressed, and in a second state, said spring is released against said thrusting weight, to urge said thrusting weight along said motor shaft, to deliver said axial forces to said capsule housing.

17. The gastrointestinal capsule of claim 16, said motor shaft passing through said thrusting weight, said motor shaft having an external interrupted thread, and said thrusting weight having a threaded internal surface generally circumferentially complementary to a threading of said external interrupted thread,

whereby, in said first state, said external interrupted thread engages said threaded internal surface, and in said second state, said threaded internal surface is disengaged and longitudinally free with respect to said external interrupted thread.

18. The gastrointestinal capsule of claim 16, said motor shaft passing through said thrusting weight, said thrusting weight adapted to turn with said motor shaft, said motor shaft having an external interrupted thread, and said thrusting weight having a threaded internal surface generally circumferentially complementary to a threading of said external interrupted thread,

said axial perturbation arrangement further adapted such that in said first state, said external interrupted thread engages said threaded internal surface to compress said spring, and in said second state, said threaded internal surface is disengaged and longitudinally free with respect to said external interrupted thread, such that said spring is released against said thrusting weight.

19. A gastrointestinal capsule (GIC) comprising:

(a) a capsule housing having a longitudinal axis;

(b) a thrusting mechanism, disposed within said capsule housing, said thrusting mechanism having an active mode, and a passive mode with respect to said active mode,

said thrusting mechanism including;

(i) a rotatably mounted eccentric weight,

said thrusting mechanism adapted, in said active mode, to rotate said eccentric weight thereby to exert radial forces on said capsule housing, in a radial direction with respect to said longitudinal axis, and

(ii) an axial perturbation arrangement including;

a motor;

a motor shaft, disposed at least partially in a direction along said longitudinal axis, said motor shaft operatively connected to, and driven by, said motor; and

a thrusting weight associated with said motor shaft,

said axial perturbation arrangement adapted to at least periodically urge said thrusting weight along said motor shaft, to deliver axial forces to said capsule housing,

such that when the gastrointestinal capsule is disposed within a gastrointestinal tract of a user, and said thrusting mechanism is in said active mode, the gastrointestinal capsule stimulates a wall of said gastrointestinal tract; and

(c) a battery adapted to power said thrusting mechanism;

said active mode including a series of at least two pulses of said radial forces, said series having a first duration, said passive mode having a second duration,

wherein an activation cycle is defined by said series of pulses followed by said second duration, and wherein said first duration is within a range of 1-10 seconds.