Dual flow sorbent cartridge
First Claim
1. A sorbent cartridge, comprising:
- at least one cartridge body having a first inlet port and a second inlet port,a common conduit;
one or more valves to direct dialysate to travel from the common conduit to either the first inlet port that defines a first flow path or the second inlet port that defines a second flow path through the sorbent cartridge to an outlet port; and
the first flow path flowing through at least a urease containing material and a zirconium phosphate material in the cartridge that is not in fluid communication with the second flow path, the second flow path flowing through at least a mixed anion and cation de-ionization resin in the sorbent cartridge not in fluid communication with the first flow path;
wherein the sorbent cartridge is capable of removing at least one impurity or waste species from a fluid.
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Accused Products
Abstract
Disclosed are systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, a sorbent cartridge with at least two separate flow paths, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.
153 Citations
24 Claims
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1. A sorbent cartridge, comprising:
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at least one cartridge body having a first inlet port and a second inlet port, a common conduit; one or more valves to direct dialysate to travel from the common conduit to either the first inlet port that defines a first flow path or the second inlet port that defines a second flow path through the sorbent cartridge to an outlet port; and the first flow path flowing through at least a urease containing material and a zirconium phosphate material in the cartridge that is not in fluid communication with the second flow path, the second flow path flowing through at least a mixed anion and cation de-ionization resin in the sorbent cartridge not in fluid communication with the first flow path;
wherein the sorbent cartridge is capable of removing at least one impurity or waste species from a fluid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A method comprising:
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measuring the conductivity of a fluid prior to entering a sorbent cartridge; wherein the sorbent cartridge comprises at least one cartridge body;
a common conduit;
one or more valves to direct dialysate to travel from the common conduit to either a first inlet port that defines a first flow path or a second inlet port that defines a second flow path through the sorbent cartridge to an outlet port;dividing the fluid between the first inlet port and the second inlet port of the sorbent cartridge based upon the conductivity of the fluid; removing one or more waste species from the fluid and adjusting the sodium ion concentration of the fluid; and recovering the fluid from the outlet port of the sorbent cartridge wherein the first flow path connected to the first inlet port includes a urease material and a zirconium phosphate material that is not in fluid communication with the second flow path; and
wherein the second flow path is connected to the second inlet port including a mixed anion and cation de-ionization resin in the sorbent cartridge not in fluid communication with the first flow path.
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24. A system for performing kidney replacement treatment, comprising:
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a hemodialysis system having a controlled compliance dialysis circuit, a dialyzer with a high permeability dialysis membrane, a blood inlet end for receiving blood, a blood outlet end for allowing blood out of the dialyzer, a dialysate inlet end for receiving dialysate and a dialysate outlet end for allowing dialysate out of the dialyzer, wherein the blood and the dialysate contact different sides of the dialysis membrane; an extracorporeal circuit having a conduit for receiving blood from a subject and a conduit for returning blood to the subject and a blood pump for conveying blood from the subject, to the dialyzer and back to the subject; and a dialysis circuit having a sorbent cartridge for removing impurities and waste species from the dialysate, one or more conduits for conveying dialysate between the sorbent cartridge and the dialyzer, and a dialysate pump for conveying dialysate from the sorbent cartridge, to the dialyzer and back to the sorbent cartridge, the sorbent cartridge having a dialysate inlet end and a dialysate outlet end; wherein the sorbent cartridge comprises; at least one cartridge body having a first inlet port and a second inlet port;
a common conduit;
one or more valves to direct dialysate to travel from the common conduit to either a first inlet port that defines a first flow path or a second inlet port that defines a second flow path through the sorbent cartridge to an outlet port; andthe first flow path flowing through at least a urease containing material and a zirconium phosphate material in the cartridge body that is not in fluid communication with the second flow path, the second flow path flowing through at least a mixed anion and cation de-ionization resin in the sorbent cartridge not in fluid communication with the first flow path;
wherein the sorbent cartridge is capable of removing at least one impurity or waste species from a fluid.
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Specification