Feedback controlled gastro-intestinal stimulation

• US 9,707,392 B2
• Filed: 10/03/2008
• Issued: 07/18/2017
• Est. Priority Date: 10/05/2007
• Status: Active Grant

• Current Assignee: UTI Limited Partnership
• Original Assignee: UTI Limited Partnership
• Inventors: Mintchev, Martin P.
• Primary Examiner(s): Alter, Alyssa M
• Application Number:
  US12/681,775
• Publication Number:
  US 20100222841A1
• Time in Patent Office: 3,210 Days
• Field of Search: 607 40
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/1107 Measuring contraction of parts of the body, e.g. organ, muscle apparatus for measuring work or force in general G01L
• CPC Class Codes: A61B 5/4238 stomach
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control

Abstract

Neural Gastric Electrical Stimulation (NGES) is a new method for invoking gastric contractions under microprocessor control. However, optimization of this technique using feedback mechanisms to minimize power consumption and maximize effectiveness has been lacking. An apparatus and method are provided for inducing controlled gastro paresis. The apparatus comprises a contraction sensor, a stomach contraction generator, and a controller. The contraction sensor is responsive to circumferential contractions of the stomach, and outputs a signal indicative of a circumferential contraction. The stomach contraction generator induces a circumferential contraction upon receipt of an electrical signal from the controller. The controller sends the electrical signal to the generator upon receipt of the output signal from the sensor. The method comprises the steps of sensing a circumferential contraction of the stomach, and invoking a circumferential contraction of the stomach in response to sensing the circumferential contraction.

Claims

1. An apparatus comprising:

a set of electrodes adapted for implantation at a first portion of gastrointestinal tract, wherein said set of electrodes is configured for both detecting a natural circumferential contraction at the first portion of gastrointestinal tract and for providing electrical stimulation to induce a circumferential contraction to the first portion of gastrointestinal tract; and

a controller configured to receive a natural circumferential contraction signal from said set of electrodes, and is further configured to output an electrical signal to the same said set of electrodes to induce a circumferential contraction of the gastrointestinal tract only upon receiving the natural circumferential contraction signal from said set of electrodes.

2. The apparatus of claim 1 further comprising a second set of electrodes for providing a second electrical stimulation to induce a second circumferential contraction, wherein said second set of electrodes is adapted for implantation at a second portion of the gastrointestinal tract that is distal to the first portion of the gastrointestinal tract.

3. The apparatus of claim 2, wherein said controller is configured to induce circumferential contraction to said set of electrodes and said second set of electrodes such that the circumferential contractions generated by said set of electrodes and said second set of electrodes overrides natural contractions of the gastrointestinal tract.

4. The apparatus of claim 3, wherein said controller is configured to induce circumferential contractions to said set of electrodes and said second set of electrodes according to a desired synchronized pattern based on information of natural contractions of the gastrointestinal tract.

5. The apparatus of claim 1, wherein said controller comprises an oscillator that applies an interrogation current to said set of electrodes to measure impedance between electrodes for determining occurrence of circumferential contraction at the first portion of the gastrointestinal tract.

6. The apparatus of claim 5, wherein said oscillator is frequency-adjustable.

7. The apparatus of claim 6, wherein said controller is configured to sweep said oscillator through a range of frequencies greater than 5 kHz.

8. The apparatus of claim 7, wherein said controller is configured to sweep said oscillator to a maximum frequency of 500 kHz or less.

9. A method for inducing controlled gastroparesis in the stomach of a subject, said method comprising:

implanting a set of electrodes to a first portion of a subject'"'"'s stomach, wherein said set of electrodes are configured both to detect a natural circumferential contraction signal from the first portion of the subject'"'"'s stomach and to generate a circumferential contraction signal at the first portion of the subject'"'"'s stomach;

detecting the natural circumferential contraction signal from the first portion of the subject'"'"'s stomach using said set of electrodes; and

providing an electrical signal to said set of electrodes using a controller to induce a circumferential contraction at the first portion of the subject'"'"'s stomach,

wherein said controller is configured to provide the electrical signal to said set of electrodes to induce circumferential contraction only upon after receiving the natural circumferential contraction signal from said set of electrodes.

10. The method of claim 9, wherein said set of electrodes are implanted subserosal.

11. The method of claim 9 further comprising the step of implanting a second set of electrodes for providing a second electrical stimulation to induce a second circumferential contraction, wherein said second set of electrodes are implanted at a second portion of the gastrointestinal tract that is distal to the first portion of the gastrointestinal tract.

12. The method of claim 11, wherein said controller is configured to provide the electrical signal to said set of electrodes and said second set of electrodes such that the circumferential contraction generated by said set of electrodes and said second set of electrodes overrides natural contractions of the gastrointestinal tract.

13. An apparatus comprising:

a first set of electrodes and a second set of electrodes, wherein both of said first set of electrodes and said second set of electrodes are adapted for implantation at a gastrointestinal tract, and wherein both of said first set of electrodes and said second set of electrodes are configured to (i) generate a circumferential contraction signal when the natural circumferential contraction is detected;

or (ii) provide electrical stimulation to induce a circumferential contraction; and

a controller configured to provide interchangeable utilization of each of said set of electrodes as either a circumferential contraction signal sensor or as a circumferential contraction generator, wherein said controller is further configured to generate a signal to induce circumferential contraction only upon receiving a contraction signal from one of said set of electrodes.