Controllable rotating ultrasound therapy applicator

• US 9,707,413 B2
• Filed: 03/09/2011
• Issued: 07/18/2017
• Est. Priority Date: 03/09/2010
• Status: Active Grant

• Current Assignee: Profound Medical Inc. (Profound Medical Corp.)
• Original Assignee: Profound Medical Inc. (Profound Medical Corp.)
• Inventors: Donaldson, Sean, Mahon, Cameron, Chopra, Rajiv
• Primary Examiner(s): Dieterle, Jennifer
• Assistant Examiner(s): BOR, HELENE CATHERINE
• Application Number:
  US12/932,920
• Publication Number:
  US 20110295161A1
• Time in Patent Office: 2,323 Days
• Field of Search: 600411, 600462, 600439, 606 96, 606 27
• CPC Class Codes: A61B 18/1485 having a short rigid shaft for accessing the inner body through natural openings
• CPC Class Codes: A61B 18/1815 using microwaves
• CPC Class Codes: A61B 2017/00274 Prostate operation, e.g. prostatectomy, turp, bhp treatment
• CPC Class Codes: A61B 2018/00011 with fluids
• CPC Class Codes: A61B 2018/00023 closed, i.e. without wound contact by the fluid
• CPC Class Codes: A61B 2018/00517 Urinary bladder or urethra
• CPC Class Codes: A61B 2018/00547 Prostate
• CPC Class Codes: A61B 2090/374 NMR or MRI
• CPC Class Codes: A61B 2090/378 using ultrasound
• CPC Class Codes: A61F 7/12 Devices for heating or cooling internal body cavities
• CPC Class Codes: A61N 2007/0078 with multiple treatment transducers
• CPC Class Codes: A61N 2007/0091 with moving parts, e.g. transducers, lenses, reflectors
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00
• CPC Class Codes: A61N 7/022 intracavitary

Abstract

An apparatus is disclosed for thermal therapy in a male prostate patient. The apparatus includes, in preferred embodiments, a long tubular element that is to be inserted into a patient'"'"'s urethra so that a first tip end of it reaches up into the patient'"'"'s diseased prostate. The elongated portion includes a narrow cylindrical tube within which an ultrasonic array is disposed along the long axis of the cylinder. Fluid is pumped into and out of a treatment zone of said patient as needed to control a temperature of a region in said treatment zone. A motorized driver is used to controllably rotate said elongated portion and the ultrasound array therein about the long axis of the apparatus so as to deliver acoustic energy to said diseased tissue. Various control and monitoring components may be used in conjunction with the present apparatus to design, control, and terminate the therapy.

Claims

1. An apparatus for thermal therapy in a patient, comprising:

an elongated cylindrical body having a first end thereof sized and configured for insertion into a male urethra;

an array of ultrasonic sources disposed within said elongated cylindrical body and arranged along an axis of said elongated cylindrical portion proximal to said first end of the elongated cylindrical portion, the ultrasonic sources being electrically driven to provide thermal therapy in said patient;

a transition body portion directly connected to a second end of said elongated cylindrical body, said transition body portion including a flared portion that limits a depth of said insertion into said male urethra and a flanged portion, said flanged portion disposed between said second end and said flared portion;

an elongated printed circuit board disposed in said elongated cylindrical body and extending from said first end of said elongated cylindrical body to said transition body portion such that a portion of said elongated circuit board is disposed outside said depth of said insertion, said circuit board including a plurality of printed circuit lines respectively coupled to a plurality of said ultrasonic sources of said array, said circuit lines providing power and control signals to said respective plurality of ultrasonic sources and driving said sources to deliver acoustic emissions of respective frequency and power depending on the respective power and control signals, said plurality of circuit lines on said circuit board being electrically and mechanically coupled to said plurality of ultrasonic sources of said array by way of respective conducting epoxy points or pads of finite thickness so as to cause a gas-filled separation between back sides of said ultrasonic sources and said circuit board therefore so as to cause an outward radiation of ultrasonic energy from an outward face of said ultrasonic sources, wherein said epoxy points or pads are disposed between said ultrasonic sources and said circuit board, said gas-filled separation having a width determined by said thickness of said epoxy points or pads and a height determined by a distance between adjacent epoxy points or pads;

a rotational mechanical coupling directly connected to said flanged portion that supports and secures said elongated cylindrical portion, said rotational mechanical coupling further designed and arranged to permit mechanical rotation of said elongated cylindrical portion about said axis thereof and including a geared wheel configured to mechanically engage a rotational driver to convert a rotational movement of said driver to a corresponding rotational movement of said geared element; and

at least one fluid conduit running through said rotational mechanical coupling permitting a fluid to circulate into and then out of said apparatus by flowing from said second end towards said first end of the elongated cylindrical portion and back again.

2. The apparatus of claim 1, further comprising an orifice proximal to said first end of said elongated cylindrical portion, the orifice arranged to draw a body fluid from an interior of said patient, through said elongated cylindrical portion and out of the apparatus.

3. The apparatus of claim 1, said array of ultrasonic sources being disposed on an elongated support plate having a first elongated portion shaped and sized to fit within an interior cavity in said elongated cylindrical portion proximal to said first end and a second widened portion having a flattened and paddle-like shape proximal to said second end including a plurality of printed connection points or pads.

4. The apparatus of claim 3, said plurality of printed circuit electrically connected at one end thereof to said ultrasonic sources and electrically connected at another end thereof to a source of said power and control signals, said circuit lines terminating in printed circuit board connectors disposed at said other end proximal to said second widened portion of the elongated support plate.

5. The apparatus of claim 1, further comprising mechanical fluid couplings at an end thereof and distal from said first end of the elongated cylindrical portion, the mechanical fluid couplings respectively connectable to a fluid supply line and to a fluid discharge line for circulating fluid into and out of said apparatus.

6. The apparatus of claim 1, said apparatus configured to be magnetic field compatible allowing the apparatus to be used in a magnetic resonance imaging (MRI) treatment facility without substantially interfering with the operation of such magnetic imaging.

7. The apparatus of claim 6, said apparatus possessing a substantially radially symmetrical magnetic profile so that rotation of said apparatus during treatment within a magnetic imaging field would have little or no detrimental impact on magnetic imaging performed in conjunction with said treatment.

8. The apparatus of claim 1, wherein said transition portion is disposed between (a) first and second mechanical interfaces of said fluid conduit and (b) said second end, said first and second mechanical interfaces coupling intake and outtake connections, respectively, to respective fluid couplings that extend from said mechanical interfaces to said second end of said elongated cylindrical body.

9. The apparatus of claim 8, further comprising electrical couplings extending from said transition body portion to said second end of said elongated cylindrical body.

10. The apparatus of claim 1, wherein said transition body portion comprises an optically transparent material, said optically transparent material disposed and arranged to allow visual inspection of said fluid conduit.

11. The apparatus of claim 10, wherein said optically transparent material comprises a clear plastic.

12. The apparatus of claim 1, wherein said array of ultrasonic sources includes a first dummy source that is not electrically driven to provide thermal therapy in said patient, said first dummy source disposed at a first end of said array of ultrasonic sources.

13. The apparatus of claim 12, wherein said array of ultrasonic sources includes a second dummy source that is not electrically driven to provide thermal therapy in said patient, said second dummy source disposed at a second end of said array of ultrasonic sources.