System and method for measuring an analyte in a sample and correcting for interferents
First Claim
1. A method of determining blood glucose concentration with a glucose measurement system that includes a test strip and test meter, the test meter having a microcontroller configured to apply a plurality of test voltages comprising first, second and third test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip, the method comprising:
- inserting the test strip into a strip port connector of the test meter to connect at least two electrodes of the test strip to a strip measurement circuit;
initiating a test sequence after deposition of a sample by causing the first test voltage to be applied, the first test voltage causing a transformation of analytes in the sample from one form to a different form;
switching a first test voltage to a second test voltage different than the first test voltage;
changing the second test voltage to a third test voltage different from the second voltage;
measuring a second current output of the current transient from the electrodes after the changing from the second test voltage to the third test voltage;
estimating a current that approximates a steady state current output of the current transient after the third test voltage is maintained at the electrodes;
calculating a blood glucose concentration based on the first, second and third current output of the current transient with an equation of the form;
7 Assignments
0 Petitions
Accused Products
Abstract
Methods and systems to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip so that a glucose concentration can be determined that account for interferent substances in the body fluid sample. A method of determining blood glucose concentration with a glucose measurement system that includes a test strip and test meter. The test meter has a microcontroller configured to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip.
-
Citations
17 Claims
-
1. A method of determining blood glucose concentration with a glucose measurement system that includes a test strip and test meter, the test meter having a microcontroller configured to apply a plurality of test voltages comprising first, second and third test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip, the method comprising:
-
inserting the test strip into a strip port connector of the test meter to connect at least two electrodes of the test strip to a strip measurement circuit; initiating a test sequence after deposition of a sample by causing the first test voltage to be applied, the first test voltage causing a transformation of analytes in the sample from one form to a different form; switching a first test voltage to a second test voltage different than the first test voltage; changing the second test voltage to a third test voltage different from the second voltage; measuring a second current output of the current transient from the electrodes after the changing from the second test voltage to the third test voltage; estimating a current that approximates a steady state current output of the current transient after the third test voltage is maintained at the electrodes; calculating a blood glucose concentration based on the first, second and third current output of the current transient with an equation of the form; - View Dependent Claims (2)
-
-
3. A method of determining blood glucose concentration with a glucose measurement system that includes a test strip and test meter, the test meter having a microcontroller configured to apply a plurality of test voltages comprising a first test voltage, a second test voltage, and a third test voltage to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip, the method comprising:
-
inserting the test strip into a strip port connector of the test meter to connect at least two electrodes of the test strip to a strip measurement circuit; initiating a test sequence after deposition of a sample by applying the first test voltage; causing a transformation of analytes in the sample from one form to a different form; switching the first test voltage to a second test voltage different than the first test voltage; changing the second test voltage to a third test voltage different from the second voltage; measuring a second current output of the current transient from the electrodes after the changing from the second test voltage to the third test voltage; estimating approximate steady state current output of the current transient after the third test voltage is maintained at the electrodes; calculating a blood glucose concentration based on the first, second and third current output of the current transient with an equation of the form; - View Dependent Claims (4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
-
-
15. A blood glucose measurement system comprising:
-
an analyte test strip including; a substrate having a reagent disposed thereon; at least two electrodes proximate the reagent in test chamber; an analyte meter including; a strip port connector disposed to connect to the two electrodes; a power supply; and a microcontroller electrically coupled to the strip port connector and the power supply, the microcontroller programmed to, apply a first test voltage; switch the first test voltage to a second test voltage different than the first test voltage; change the second test voltage to a third test voltage different from the second test voltage, measure a second current output of the current transient from the electrodes after the change from the second test voltage to the third test voltage, estimate a current that approximates a steady state current output of the current transient after the third test voltage is maintained at the electrodes, and determine a glucose concentration G1 and a corrected glucose concentration Gcorr to account for interfering agents so that at least 97% of corrected test results are within respective bias criterion of ±
10 mg/dL at 65 mg/dL, 240 mg/dL, or at 450 mg/dL as compared to reference YSI data;
±
12 mg/dL at 65 mg/dL, 240 mg/dL, or 450 mg/dL as compared to reference YSI data; and
±
15 mg/dL at 65 mg/dL, 240 mg/dL, or 450 mg/dL as compared to reference YSI data, the glucose concentration and the corrected glucose concentration based on the first, second and third current output and being derived from the following equations; - View Dependent Claims (16, 17)
-
Specification