Microfluidic device with dried blood spots (Dbs) card interface
First Claim
1. A chromatography apparatus comprising:
- a first microfluidic substrate having a first substantially enclosed fluidic channel comprising a sample preparation column, one end of the first substantially enclosed fluidic channel terminating at a first fluidic port on a first side of the first microfluidic substrate and an opposite end of the first substantially enclosed fluidic channel terminating at a second fluidic port on a second side of the first microfluidic substrate;
a second microfluidic substrate having a second substantially enclosed fluidic channel comprising an analytical column, one end of the second substantially enclosed fluidic channel terminating at a first fluidic port on a first side of the second microfluidic substrate, anda dried blood spot (DBS) card having one or more dried blood spots, one side of the DBS card being coupled to the first side of the first microfluidic substrate such that one of the dried blood spots of the DBS card is in fluidic communication with the first fluidic port of the first microfluidic substrate;
wherein the first side of the second microfluidic substrate abuts the second side of the first microfluidic substrate such that the first fluidic port of the second microfluidic substrate aligns with one of the second fluidic ports of the first microfluidic substrate and the alignment produces a fluidic path comprised of the first and second substantially enclosed fluidic channels.
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Abstract
An apparatus for use in a chromatography system includes a first microfluidic substrate having a first fluidic channel. One end of the first fluidic channel terminates at a first fluidic port on a first side of the first microfluidic substrate and an opposite end of the first fluidic channel terminates at a second fluidic port on a second side of the first microfluidic substrate. A second microfluidic substrate has a second fluidic channel. One end of the second fluidic channel terminates at a first fluidic port on a first side of the second microfluidic substrate. The first side of the second microfluidic substrate abuts the second side of the first microfluidic substrate such that the fluidic port of the second microfluidic substrate aligns with one of the fluidic ports of the first microfluidic substrate and the alignment produces a fluidic path comprised of the first and second fluidic channels.
26 Citations
29 Claims
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1. A chromatography apparatus comprising:
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a first microfluidic substrate having a first substantially enclosed fluidic channel comprising a sample preparation column, one end of the first substantially enclosed fluidic channel terminating at a first fluidic port on a first side of the first microfluidic substrate and an opposite end of the first substantially enclosed fluidic channel terminating at a second fluidic port on a second side of the first microfluidic substrate; a second microfluidic substrate having a second substantially enclosed fluidic channel comprising an analytical column, one end of the second substantially enclosed fluidic channel terminating at a first fluidic port on a first side of the second microfluidic substrate, and a dried blood spot (DBS) card having one or more dried blood spots, one side of the DBS card being coupled to the first side of the first microfluidic substrate such that one of the dried blood spots of the DBS card is in fluidic communication with the first fluidic port of the first microfluidic substrate; wherein the first side of the second microfluidic substrate abuts the second side of the first microfluidic substrate such that the first fluidic port of the second microfluidic substrate aligns with one of the second fluidic ports of the first microfluidic substrate and the alignment produces a fluidic path comprised of the first and second substantially enclosed fluidic channels. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A chromatography apparatus comprising:
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a first microfluidic substrate comprising a plurality of spatially separated substantially enclosed fluidic channels each comprising a sample preparation column formed therein, one end of each of the substantially enclosed fluidic channels terminating at a different first fluidic port on a first side of the microfluidic substrate, and an opposite end of each substantially enclosed fluidic channel terminating at a different second fluidic port on a second side opposite the first side of the microfluidic substrate, and a second microfluidic substrate having a second substantially enclosed fluidic channel comprising an analytical column, one end of the second substantially enclosed fluidic channel terminating at a first fluidic port on a first side of the second microfluidic substrate, and wherein the first side of the second microfluidic substrate abuts the second side of the first microfluidic substrate such that the first fluidic port of the second microfluidic substrate aligns with one of the fluidic ports of the first microfluidic substrate and the alignment produces a fluidic path comprised of the first and second substantially enclosed fluidic channels. - View Dependent Claims (14, 15, 16, 17, 18, 19)
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20. A chromatography apparatus, comprising:
a microfluidic cartridge housing a microfluidic device comprised of; a first microfluidic substrate having a first substantially enclosed fluidic channel comprising a sample preparation column, one end of the first substantially enclosed fluidic channel terminating at a first fluidic port on a first side of the first microfluidic substrate and an opposite end of the first substantially enclosed fluidic channel terminating at a second fluidic port on a second side of the first microfluidic substrate; a dried blood spot (DBS) card having one or more dried blood spots, one side of the DBS card being coupled to the first side of the first microfluidic substrate such that one of the dried blood spots of the DBS card is in fluidic communication with the first fluidic port of the first microfluidic substrate; and a second microfluidic substrate having a second substantially enclosed fluidic channel comprising an analytical column, one end of the second substantially enclosed fluidic channel terminating at a first fluidic port on a first side of the second microfluidic substrate, wherein the first side of the second microfluidic substrate abuts the second side of the first microfluidic substrate such that the first fluidic port of the second microfluidic substrate aligns with one of the second fluidic ports of the first microfluidic substrate and the alignment produces a fluidic path comprised of the first and second substantially enclosed fluidic channels, and wherein the first microfluidic substrate is removably coupled to the second microfluidic substrate and removable from the cartridge housing. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29)
Specification