Analyte sensors comprising leveling agents

• US 9,713,442 B2
• Filed: 03/16/2015
• Issued: 07/25/2017
• Est. Priority Date: 09/30/2008
• Status: Active Grant

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories)
• Inventors: Bommakanti, Balasubrahmanya S., Sandhu, Gary, Hoss, Udo
• Primary Examiner(s): JANG, CHRISTIAN YONGKYUN
• Application Number:
  US14/659,013
• Publication Number:
  US 20150182155A1
• Time in Patent Office: 862 Days
• CPC Class Codes: A61B 5/002 Monitoring the patient using a local or closed circuit, e.g. in a room or building A61B5/0017 takes precedence
• CPC Class Codes: A61B 5/0022 Monitoring a patient using a global network, e.g. telephone networks, internet
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: C12Q 1/001 Enzyme electrodes
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: G01N 27/327 Biochemical electrodes , e.g. electrical or mechanical details for in vitro measurements

Abstract

Generally, embodiments of the invention relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved uniformity of distribution of one or more components of the sensor by inclusion of a low surface tension polymer leveling agent, where the components are disposed proximate to a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.

Claims

1. An electrode comprising:

a sensing layer disposed thereon, and

a membrane disposed over the sensing layer comprising a low surface tension polymer selected from polydimethylsiloxane (H₃C)₃Si[Si(CH₃)₂O]_nSi(CH₃)₃, polyether modified polydimethylsiloxane [CH₂O—

]_n[Si(CH₃)₂O]_n—

[CH₂O—

]_n, poly((eo)(po))butyl terminated polydimethylsiloxane CH₃—

{[CH₂CH₂O]_n—

[CH₂O—

]_n}_n[Si(CH₃)₂O]_n—

{[CH₂O—

]_n[CH₂CH₂O]_n}_n—

CH₃, and dimethyl, methyl (polyethylene oxide acetate-capped) siloxane, wherein n is an integer in a range of from about 1 to 500, wherein the low surface tension polymer comprises 1% or less by weight of the total formulation of the membrane.

2. The electrode of claim 1, wherein at least a portion of the electrochemical analyte electrode is adapted to be subcutaneously positioned in a subject.

3. The electrode of claim 1, wherein the low surface tension polymer comprises a substituted or unsubstituted polyacrylate polymer or a substituted or unsubstituted polysiloxane polymer.

4. The electrode of claim 1, wherein the low surface tension polymer comprises polyether-modified polydimethylsiloxane.

5. The electrode of claim 1, wherein the sensing layer comprises a glucose-responsive enzyme.

6. The electrode of claim 5, wherein the glucose-responsive enzyme is glucose oxidase.

7. The electrode of claim 1, wherein the sensing layer comprises a redox mediator.

8. The electrode of claim 7, wherein the redox mediator comprises a ruthenium-containing complex or an osmium-containing complex.

9. The electrode of claim 1, wherein the sensing layer comprises a polymer.

10. The electrode of claim 9, wherein the polymer is covalently bound to a glucose responsive enzyme or a redox mediator.

11. The electrode of claim 9, wherein the polymer is a hydrophilic polymer.

12. The electrode of claim 1, wherein the electrode is configured for use in an in vivo sensor.

13. The electrode of claim 1, wherein the electrode is configured for use in an in vitro sensor.