Method for modifying food intake and regulating food preference with a DPP-4 inhibitor

• US 9,713,618 B2
• Filed: 05/21/2013
• Issued: 07/25/2017
• Est. Priority Date: 05/24/2012
• Status: Active Grant

• Current Assignee: Boehringer Ingelheim International GmbH (C.H. Boehringer Sohn AG & Co. KG)
• Original Assignee: Boehringer Ingelheim International GmbH (C.H. Boehringer Sohn AG & Co. KG)
• Inventors: Mark, Michael, Klein, Thomas
• Primary Examiner(s): Landsman, Robert
• Assistant Examiner(s): Hissong, Bruce D
• Application Number:
  US13/898,963
• Publication Number:
  US 20130324463A1
• Time in Patent Office: 1,526 Days
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/522 having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• CPC Class Codes: A61K 31/7028 Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
• CPC Class Codes: A61K 38/26 Glucagons
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents

Abstract

The present invention relates to the use of a certain DPP-4 inhibitor for modifying food intake and regulating food preference.

Claims

1. A method of shifting food or taste preference or choice of a subject in need thereof away from an unhealthy food toward a healthy food, the method comprising administering to the subject an effective amount of a dipeptidyl peptidase-4 (DPP-4) inhibitor in combination with a glucagon-like peptide-1 (GLP-1) receptor agonist which is exenatide or human GLP-1, wherein the unhealthy food is a food having a high glycemic index and/or wherein mono- and/or di-saccharides constitute a large proportion of the total amount of carbohydrates and/or wherein a large proportion of the total amount of energy stems from fat, and wherein the healthy food is a food having a low glycemic index and/or wherein mono- and/or di-saccharides constitute a small proportion of the total amount of carbohydrates and/or wherein a small proportion of the total amount of energy stems from fat, wherein the DPP-4 inhibitor is administered subcutaneously.

2. The method according to claim 1, wherein the DPP-4 inhibitor is linagliptin and the GLP-1 receptor agonist is exenatide.

3. The method according to claim 1, wherein

(a) said unhealthy food is a food from one or more of the groups A) to D):

A) The glycemic index is above 60%

B) The glycemic index is above 40% and wherein more than 30% of the total amount of energy stems from fat

C) The amount of mono- and/or di-saccharides constitute more than 25% of total carbohydrate content

D) The amount of mono- and/or di-saccharides constitute more than 25% of total carbohydrate content and wherein more than 30% of the total amount of energy stems from fat; and

wherein

(b) said healthy food is food from one or more of the groups E) to H);

E) The glycemic index is below 60%

F) The glycemic index is below 40% and wherein less than 30% of the total amount of energy stems from fat

G) The amount of mono- and/or di-saccharides constitute together constitute less than 25% of the total carbohydrate content

H) The amount of mono- and/or di-saccharides constitute less than 25% of the total carbohydrate content, and wherein less than 30% of the total amount of energy stems from fat.

4. The method according to claim 1, wherein said subject is overweight or obese.

5. The method according to claim 1, wherein said subject has diabetes with or without obesity or overweight.