Systems and methods for multiple analyte detection
First Claim
1. A system for distribution of a biological sample, the system comprising:
- a substrate, wherein the substrate comprises a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber;
a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate; and
a sealing instrument comprising a roller provided with a plurality of sealing protrusions in the form of circumferential disks spaced from each other along a longitudinal axis of the roller such that each protrusion can align with a sample chamber and placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber,wherein the substrate is constructed of detection-compatible and assay-compatible materials.
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Accused Products
Abstract
Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
29 Citations
23 Claims
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1. A system for distribution of a biological sample, the system comprising:
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a substrate, wherein the substrate comprises a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber; a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate; and a sealing instrument comprising a roller provided with a plurality of sealing protrusions in the form of circumferential disks spaced from each other along a longitudinal axis of the roller such that each protrusion can align with a sample chamber and placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber, wherein the substrate is constructed of detection-compatible and assay-compatible materials. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification