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Systems and methods for multiple analyte detection

  • US 9,714,444 B2
  • Filed: 12/02/2013
  • Issued: 07/25/2017
  • Est. Priority Date: 04/26/2005
  • Status: Active Grant
First Claim
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1. A system for distribution of a biological sample, the system comprising:

  • a substrate, wherein the substrate comprises a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber;

    a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate; and

    a sealing instrument comprising a roller provided with a plurality of sealing protrusions in the form of circumferential disks spaced from each other along a longitudinal axis of the roller such that each protrusion can align with a sample chamber and placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber,wherein the substrate is constructed of detection-compatible and assay-compatible materials.

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