Non-invasive measurement of blood oxygen saturation

• US 9,717,446 B2
• Filed: 07/08/2011
• Issued: 08/01/2017
• Est. Priority Date: 07/09/2010
• Status: Active Grant

• Current Assignee: Sensitive Pty Ltd.
• Original Assignee: St Vincent's Hospital
• Inventors: Dixon, Barry, Stoddart, Paul Randall
• Primary Examiner(s): Winakur, Eric
• Assistant Examiner(s): Fardanesh, Marjan
• Application Number:
  US13/807,540
• Publication Number:
  US 20130172703A1
• Time in Patent Office: 2,216 Days
• Field of Search: None
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/6817 Ear canal
• CPC Class Codes: A61B 5/7246 using correlation, e.g. template matching or determination of similarity

Abstract

A method for non-invasive determination of oxygen saturation of blood within a deep vascular structure of a human or animal patient comprising locating on skin of the patient in a vicinity of the deep vascular structure of interest emitter and receiver elements of a light oximeter device, wherein optimal location of said elements is achieved through matching of a plethysmography trace obtained from the oximeter device to known plethysmography characteristics of the deep vascular structure of interest, wherein the emitter element emits light at wavelengths of from about 1045 nm to about 1055 nm and from about 1085 nm to about 1095 nm, and wherein oxygen saturation is determined from a ratio of light absorbed at these two wavelengths by haemoglobin in blood within the vascular structure of interest.

Claims

1. A method for non-invasive determination of oxygen saturation of blood within a deep vascular structure of a human or animal patient, the method comprising:

placing an emitter and a receiver of a light oximeter device within the external auditory canal of the patient adjacent an internal jugular vein and/or sigmoid sinus,

emitting light at a first wavelength of from 1045 nm to 1055 nm and a second wavelength from 1085 nm to 1095 nm,

receiving light at the first wavelength and the second wavelength and generating signals responsive thereto, and

determining oxygen saturation from a ratio of light absorbed at the first wavelength and the second wavelength by haemoglobin in blood within the vascular structure of interest based on the generated signals.

2. The method of claim 1 wherein the deep vascular structure of interest is the internal jugular vein.

3. The method of claim 1 wherein the determining computes a central venous blood oxygen saturation.

4. The method of claim 3 wherein the deep vascular structure of interest is the sigmoid sinus.

5. The method of claim 1 wherein the determining computes a mixed venous blood oxygen saturation.

6. The method of claim 1 wherein the first and second wavelengths of light emitted by the emitter are 1050 nm and 1090 nm.

7. The method of claim 1 wherein the emitter and receiver are separated by a distance of from 5 mm to 60 mm.

8. The method of claim 1 wherein the emitter and receiver are separated by a distance of from 10 mm to 20 mm.

9. The method of claim 1 wherein the emitter is tilted towards the receiver at an angle of about 45°

to the normal of the skin surface on which they are located.

10. A method for non-invasive determination of oxygen saturation of blood within a deep vascular structure of a human or animal patient, the method comprising:

placing, within the external auditory canal of the patient in a region adjacent to an internal jugular vein and/or sigmoid sinus, an emitter and a receiver of a light oximeter device,

adjusting the position of the emitter and the receiver by matching of a plethysmography trace obtained from the oximeter device to known plethysmography characteristics of the internal jugular vein and/or sigmoid sinus,

emitting light at a first wavelength of from 1045 nm to 1055 nm and a second wavelength of from 1085 nm and 1095 nm,

receiving light at the first wavelength and the second wavelength and generating signals responsive thereto, and

determining oxygen saturation from a ratio of light absorbed at the first and second wavelengths by haemoglobin in blood within the internal jugular vein and/or sigmoid sinus based on the generated signals.

11. A method for non-invasive determination of oxygen saturation of blood within a deep vascular structure of a human or animal patient, the method comprising:

locating a location within the external auditory canal of the patient in a region of the internal jugular vein by matching a plethysmography trace obtained from an oximeter device having an emitter and receiver to known plethysmography characteristics of the internal jugular vein,

emitting light at a first wavelength of from 1045 nm to 1055 nm and a second wavelength of from 1085 nm to 1095 nm,

receiving light at the first wavelength and the second wavelength and generating signals responsive thereto, and

determining oxygen saturation from a ratio of light absorbed at these two wavelengths by haemoglobin in blood within the internal jugular vein based on the generated signals.

12. The method of claim 11 wherein the first and second wavelengths of light emitted by the emitter are 1050 nm and 1090 nm.

13. An oximetry device comprising a central processing unit, a display, an emitter, and a receiver adapted for releasable application to human or animal skin, all of which are workably connected in use;

the emitter is adapted to emit light at a first wavelength of from 1045 nm to 1055 nm and a second wavelength of from 1085 nm to 1095 nm and the receiver is adapted to detect said light, with information relating to levels of emitted and received light being transmitted to said central processing unit;

said central processing unit being capable of matching plethysmography characteristics derived from the information relating to levels of emitted and received light with known plethysmography characteristics of a deep vascular structure of interest to identify that a location of use of the emitter and receiver on the skin is within a region of the deep vascular structure of interest;

said central processing unit also being capable of deriving from the information relating to levels of light emitted at the first and second wavelengths and received light a measurement of blood oxygen saturation within the deep vascular structure of interest, the central processing unit providing the measurement to the display for display thereon.

14. The oximetry device of claim 13 wherein the workable connection comprises wires or fibre optic cables.

15. The oximetry device of claim 13 wherein the workable connection is wireless.

16. The oximetry device of claim 13 wherein the first and second wavelengths of light emitted by the emitter are 1050 nm and 1090 nm.

17. The oximetry device of claim 13 wherein the emitter and receiver elements are adapted to be located within the external auditory canal of the human or animal, to monitor blood oxygen saturation within the adjacent internal jugular vein and/or sigmoid sinus of the human or animal.