Multiple reservoir drug delivery device and methods

• US 9,717,526 B2
• Filed: 12/19/2014
• Issued: 08/01/2017
• Est. Priority Date: 09/27/2012
• Status: Active Grant

• Current Assignee: Xerox Corporation (Xerox Holdings Corp.)
• Original Assignee: Palo Alto Research Center, Inc. (Xerox Holdings Corp.)
• Inventors: Uhland, Scott A., Curley, Timothy J., Abhishek, Ramkumar, Peeters, Eric, Linn, Felicia
• Primary Examiner(s): Matthews, Christine H
• Assistant Examiner(s): LANNU, JOSHUA DARYL DEANON
• Application Number:
  US14/577,291
• Publication Number:
  US 20150105751A1
• Time in Patent Office: 956 Days
• CPC Class Codes: A61B 17/43 for artificial insemination
• CPC Class Codes: A61D 19/024 Tube-like containers, e.g. straws
• CPC Class Codes: A61D 19/027 Devices for injecting semen into animals, e.g. syringes, guns, probes
• CPC Class Codes: A61D 7/00 Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals for reproduction or fertilisation A61D19/00 ; devices for implanting pellets, radon seeds or the like A61M37/0069
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61K 9/0034 Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
• CPC Class Codes: A61M 2005/14204 with gas-producing electrochemical cell
• CPC Class Codes: A61M 2210/1042 Alimentary tract A61M2210/0618 takes precedence
• CPC Class Codes: A61M 2210/1085 Bladder
• CPC Class Codes: A61M 2210/1433 Uterus
• CPC Class Codes: A61M 2210/1475 Vagina
• CPC Class Codes: A61M 31/00 Devices for introducing or retaining media, e.g. remedies, in cavities of the body A61M25/00 takes precedence ; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008
• CPC Class Codes: A61M 5/1408 in parallel, e.g. manifolds, sequencing valves access sites A61M39/02; tube connectors A61M39/10
• CPC Class Codes: A61M 5/145 using pressurised reservoirs, e.g. pressurised by means of pistons
• CPC Class Codes: A61M 5/155 pressurised by gas introduced into the reservoir
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407

Abstract

Devices and methods are provided for drug delivery. The device may include a housing configured for intraluminal deployment into a human or animal subject and first and second reservoirs within the housing, each reservoir having an actuation end, an opposed release end, and a plug moveable from the actuation end toward the release end. First and second drug formulations may be contained in the first and second reservoirs, respectively. The device may also include one or more actuation systems configured to drive the first and second plugs so as to drive the first and second drug formulations from the first and second reservoirs. The housing may include a porous membrane sidewall in fluid communication with the release ends of the first and second reservoirs, the porous membrane sidewall being configured to distribute the first and second drug formulations driven from the first and second reservoirs.

Claims

1. A method of drug delivery comprising:

deploying a drug delivery device into a mucosal lumen of a human or animal subject, the drug delivery device comprising a first reservoir containing a first drug formulation, a second reservoir containing a second drug formulation, and a porous membrane sidewall adjacent the mucosal lumen, wherein the mucosal lumen is a vagina, cervix, uterus, or bladder of the human or animal subject;

actuating one or more actuation systems, which comprise a microcontroller, to drive the first and second drug formulations out of the first and second reservoirs, respectively, and into the porous membrane sidewall; and

releasing the first and second drug formulations from the porous membrane sidewall to the mucosal lumen.

2. The method of claim 1, wherein the actuating one or more actuation systems comprises:

actuating a single actuation system to drive the first drug formulation out of the first reservoir; and

thereafter

actuating the single actuation system to drive the second drug formulation out of the second reservoir.

3. The method of claim 1, wherein the actuating one or more actuation systems comprises using at least one electrolytic cell to generate a displacement gas to drive the first and second drug formulations out of the first and second reservoirs.

4. The method of claim 1, wherein driving the first drug formulation out of the first reservoir is completed before any of the second drug formulation is driven out of the second reservoir.

5. The method of claim 1, wherein driving the first drug formulation out of the first reservoir overlaps with driving the second drug formulation out of the second reservoir.

6. The method of claim 1, wherein:

the device comprises a housing configured for intraluminal deployment, the first and second reservoirs being located within the housing,

the first reservoir contains a first plug and the second reservoir contains a second plug, and

actuating the one or more actuation systems to drive the first and second drug formulations out of the first and second reservoirs comprises driving the first and second plugs so as to drive the first and second drug formulations out of the first and second reservoirs.

7. A method of drug delivery comprising:

deploying a drug delivery device into a mucosal lumen of a human or animal subject, the drug delivery device comprising a first reservoir containing a first drug formulation, a second reservoir containing a second drug formulation, and a porous membrane sidewall adjacent the mucosal lumen;

actuating one or more actuation systems to drive the first and second drug formulations out of the first and second reservoirs, respectively, and into the porous membrane sidewall; and

releasing the first and second drug formulations from the porous membrane sidewall to the mucosal lumen;

wherein the porous membrane sidewall comprises a fluidic valve configured such that a critical threshold pressure from about 0.1 psi to about 100 psi is required to drive the first and second drug formulations out of the first and second reservoirs and into the porous membrane sidewall.

8. A method of drug delivery comprising:

deploying a drug delivery device into a mucosal lumen of a human or animal subject, the drug delivery device comprising;

a housing configured for intraluminal deployment,

a first reservoir located within the housing, the first reservoir containing a first drug formulation and a first plug,

a second reservoir located within the housing, the second reservoir containing a second drug formulation and a second plug, and

a porous membrane sidewall adjacent the mucosal lumen, wherein the porous membrane sidewall substantially surrounds the housing;

actuating one or more actuation systems to drive the first and second plugs so as to drive the first and second drug formulations out of the first and second reservoirs, respectively, and into the porous membrane sidewall; and

releasing the first and second drug formulations from the porous membrane sidewall to the mucosal lumen.