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Generation of anterior foregut endoderm from pluripotent cells

  • US 9,719,067 B2
  • Filed: 12/04/2015
  • Issued: 08/01/2017
  • Est. Priority Date: 04/25/2010
  • Status: Active Grant
First Claim
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1. A method of preparing an enriched population of anterior foregut endoderm cells from pluripotent cells, the method comprising:

  • (i) culturing isolated mammalian pluripotent cells under conditions that induce the pluripotent cells to form definitive endoderm cells; and

    (ii) culturing the definitive endoderm cells in the presence of an inhibitor of a bone morphogenetic protein (“

    BMP”

    ) and an inhibitor of a transforming growth factor beta (“

    TGF-β



    ) such that definitive endoderm cells form anterior foregut endoderm cells.

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