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Systems, methods, compositions and devices for in vivo magnetic resonance imaging of lungs using perfluorinated gas mixtures

  • US 9,724,015 B2
  • Filed: 01/04/2016
  • Issued: 08/08/2017
  • Est. Priority Date: 02/16/2010
  • Status: Active Grant
First Claim
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1. A method of generating lung ventilation information of a subject, comprising:

  • providing a pressurized canister of a medical grade gas mixture of perfluorinated gas and oxygen holding the medical grade mixture in a gaseous phase;

    electronically obtaining a series of 19F magnetic resonance imaging (MRI) images of lungs of a subject associated with an inhaled amount of the perfluorinated gas and oxygen mixture from the pressurized canister during wash in and wash out of the perfluorinated gas and oxygen mixture;

    electronically obtaining 1H MRI images of the lungs of the subject before or after or before and after obtaining the series of 19F MRI images while the subject breathes room air;

    electronically registering the obtained 19F MRI lung images to the obtained 1H MRI lung images of the subject;

    electronically applying lung masks to the registered 19F images to define a perimeter of a lung cavity of a respective lung; and

    thenelectronically evaluating summary parameters of different volumes of the registered 19F lung images after applying the lung masks to generate lung ventilation information that identifies regional lung ventilation defects including gas trapping,wherein the obtaining, registering, applying and evaluating steps are carried out using at least one processor.

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