Systems and methods for replacing signal artifacts in a glucose sensor data stream
DC CAFCFirst Claim
1. A glucose sensor system that detects a signal artifact that can result in an erroneous glucose concentration measurement and responds to the detected signal artifact differently depending on a corresponding evaluated level of severity, the system comprising:
- an electrochemical glucose sensor comprising a plurality of electrodes and an enzyme-containing membrane, wherein the enzyme-containing membrane is positioned to provide a medium for a conductive pathway between electrodes of the plurality of electrodes when a voltage is present across the electrodes while the electrochemical glucose sensor is in contact with a biological sample; and
sensor electronics comprising a processor for executing a computer program code stored in a memory to cause the sensor electronics to;
apply a voltage across the electrodes of the electrochemical glucose sensor,measure a signal response of the electrochemical glucose sensor responsive to the applied voltage, the measured signal response having a signal content associated with a local environment at the electrodes, wherein the local environment contributes to a signal artifact in a glucose signal generated by the electrochemical glucose sensor,evaluate a level of severity of the signal artifact based at least in part on the signal content of the measured signal response, anddynamically adjust the sensor electronics based on the level of severity evaluated to generate;
(i) a first glucose value for display based on an output from the electrochemical glucose sensor when the signal artifact is evaluated having a first level of severity, and(ii) a second glucose value, different from the first glucose value, for display based on the output from the electrochemical glucose sensor when the signal artifact is evaluated having a second level of severity different from the first level of severity, wherein the second glucose value accounts for the signal artifact affecting glucose measurement.
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Litigations
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Accused Products
Abstract
Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.
681 Citations
44 Claims
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1. A glucose sensor system that detects a signal artifact that can result in an erroneous glucose concentration measurement and responds to the detected signal artifact differently depending on a corresponding evaluated level of severity, the system comprising:
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an electrochemical glucose sensor comprising a plurality of electrodes and an enzyme-containing membrane, wherein the enzyme-containing membrane is positioned to provide a medium for a conductive pathway between electrodes of the plurality of electrodes when a voltage is present across the electrodes while the electrochemical glucose sensor is in contact with a biological sample; and sensor electronics comprising a processor for executing a computer program code stored in a memory to cause the sensor electronics to; apply a voltage across the electrodes of the electrochemical glucose sensor, measure a signal response of the electrochemical glucose sensor responsive to the applied voltage, the measured signal response having a signal content associated with a local environment at the electrodes, wherein the local environment contributes to a signal artifact in a glucose signal generated by the electrochemical glucose sensor, evaluate a level of severity of the signal artifact based at least in part on the signal content of the measured signal response, and dynamically adjust the sensor electronics based on the level of severity evaluated to generate; (i) a first glucose value for display based on an output from the electrochemical glucose sensor when the signal artifact is evaluated having a first level of severity, and (ii) a second glucose value, different from the first glucose value, for display based on the output from the electrochemical glucose sensor when the signal artifact is evaluated having a second level of severity different from the first level of severity, wherein the second glucose value accounts for the signal artifact affecting glucose measurement. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A glucose sensor system, the system comprising:
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an electrochemical glucose sensor configured to be in contact with a biological sample for measuring a glucose concentration, wherein the electrochemical glucose sensor comprises a first electrode, a second electrode, and an enzyme-containing film; sensor electronics comprising a processor for executing a computer program code stored in a memory to cause the sensor electronics to; apply a voltage to the electrochemical glucose sensor at a first setting, switch the voltage applied to the electrochemical sensor to a different setting, measure a signal response of the electrochemical glucose sensor responsive to the switching, evaluate a severity associated with a signal artifact based on the measured signal response of the electrochemical glucose sensor to the switching, wherein the signal artifact is associated with a non-glucose rate limiting phenomenon, and generate an estimated glucose concentration value when the severity associated with the signal artifact is evaluated to be under a predetermined threshold, wherein the estimated glucose concentration value accounts for the severity associated with the signal artifact; and a user interface configured to display the estimated glucose concentration value. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A glucose sensor system, the system comprising:
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an electrochemical glucose sensor configured to be in contact with a biological sample for measuring a glucose concentration, wherein the electrochemical glucose sensor comprises a first electrode, a second electrode, and an enzyme-containing film; sensor electronics comprising a processor for executing a computer program code stored in a memory to cause the sensor electronics to; apply a voltage to the electrochemical glucose sensor at a first setting, switch the voltage applied to the electrochemical sensor to a different setting, measure a signal response of the electrochemical glucose sensor responsive to the switching, evaluate a severity associated with a signal artifact based on the measured signal response of the electrochemical glucose sensor to the switching, wherein the signal artifact is associated with a non-glucose rate limiting phenomenon, and generate; (i) a first glucose value for display based on an output from the electrochemical glucose sensor when the signal artifact is evaluated having a first severity level, and (ii) a second glucose value different from the first glucose value for display based on the output from the electrochemical glucose sensor when the signal artifact is evaluated having a second severity level different from the first severity level, wherein the second glucose value accounts for the signal artifact affecting the glucose concentration measurement; and a user interface configured to display; (i) the first glucose value when the signal artifact is evaluated having the first severity level; and (ii) the second glucose value when the signal artifact is evaluated having the second severity level. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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37. A glucose sensor system, the system comprising:
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an electrochemical glucose sensor configured to be in contact with a biological sample for measuring a glucose concentration, wherein the electrochemical glucose sensor comprises a first electrode, a second electrode, and an enzyme-containing film; sensor electronics comprising a processor for executing a computer program code stored in a memory to cause the sensor electronics to; apply a voltage to the electrochemical glucose sensor at a first setting, switch the voltage applied to the electrochemical sensor to a different setting, measure a signal response of the electrochemical glucose sensor responsive to the switching, wherein the measured signal response is a time-varying voltage response of the electrochemical glucose sensor, evaluate a severity associated with a signal artifact based on the measured signal response of the electrochemical glucose sensor to the switching, wherein the signal artifact is associated with a non-glucose rate limiting phenomenon, and generate an estimated glucose concentration value when the severity associated with the signal artifact is evaluated to be under a predetermined threshold, wherein the estimated glucose concentration value accounts for the severity associated with the signal artifact; and a user interface configured to; display a first screen presenting generated glucose concentration data over a first time period, display a second screen presenting generated glucose concentration data over a second time period, wherein the second time period is different in length from the first time period, display a third screen presenting the estimated glucose concentration value, allow a user to toggle between the first screen, the second screen, and the third screen, and generate an alert responsive to detection of a hyperglycemic condition or a hypoglycemic condition. - View Dependent Claims (38, 39, 40, 41, 42, 43)
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44. A glucose sensor system, the system comprising:
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an electrochemical glucose sensor configured to be in contact with a blood sample for measuring a glucose concentration, wherein the electrochemical glucose sensor comprises a first electrode, a second electrode, and an enzyme-containing film; sensor electronics comprising a processor for executing a computer program code stored in a memory to cause the sensor electronics to; apply a voltage to the electrochemical glucose sensor at a first setting, switch the voltage applied to the electrochemical sensor to a different setting, measure a signal response of the electrochemical glucose sensor responsive to the switching, wherein the measured signal response is a voltage response of the electrochemical glucose sensor, evaluate a severity associated with a signal artifact based on the measured signal response of the electrochemical glucose sensor to the switching, wherein the signal artifact is associated with a condition selected from the group consisting of a pH, a temperature, a pressure, an available electrode surface area, and a biochemical species, and generate; (i) a first glucose value for display based on an output from the electrochemical glucose sensor when the signal artifact is evaluated having a first severity level, and (ii) a second, different glucose value for display based on the output from the electrochemical glucose sensor when the signal artifact is evaluated having a second severity level different from the first severity level, wherein the second glucose value accounts for the signal artifact affecting glucose measurement; and a user interface configured to; display the first glucose value when the signal artifact is evaluated having the first severity level, display the second glucose value when the signal artifact is evaluated having the second severity level, display a first screen presenting generated glucose concentration data over a first time period, display a second screen presenting generated glucose concentration data over a second time period, wherein the second time period is different in length from the first time period, display a third screen presenting; (i) the first glucose value when the signal artifact is evaluated having the first severity level, and (ii) the second glucose value when the signal artifact is evaluated having the second severity level, allow a user to toggle between the first screen, the second screen, and the third screen, and generate an alert responsive to detection of a hyperglycemic condition or a hypoglycemic condition.
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Specification