Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions

• US 9,724,119 B2
• Filed: 12/02/2015
• Issued: 08/08/2017
• Est. Priority Date: 05/25/2006
• Status: Expired due to Fees

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Lee, Hotaik, Smith, Nadine B., Francischelli, David E., Keogh, James R., Skarda, James R., Hissong, James B., Stewart, Mark T.
• Primary Examiner(s): Brutus, Joel F
• Application Number:
  US14/956,600
• Publication Number:
  US 20160157883A1
• Time in Patent Office: 615 Days
• Field of Search: 600427
• CPC Class Codes: A61B 2017/320069 for ablating tissue
• CPC Class Codes: A61B 2017/32007 with suction or vacuum means
• CPC Class Codes: A61B 2017/320071 with articulating means for working tip
• CPC Class Codes: A61B 2017/320078 Tissue manipulating surface
• CPC Class Codes: A61B 2018/00291 using suction
• CPC Class Codes: A61B 2034/2051 Electromagnetic tracking systems
• CPC Class Codes: A61B 2090/378 using ultrasound
• CPC Class Codes: A61B 2090/3782 transmitter or receiver in catheter or minimal invasive instrument
• CPC Class Codes: A61B 34/20 Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• CPC Class Codes: A61B 8/4281 characterised by sound-transmitting media or devices for coupling the transducer to the tissue
• CPC Class Codes: A61N 2007/0078 with multiple treatment transducers
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00
• CPC Class Codes: A61N 7/022 intracavitary

Abstract

A device and method for ablating tissue is disclosed comprising the steps of acquiring an anatomical image of a patient, correlating the image to the patient, guiding an ablating member within the patient while tracking the position of the ablating member in the patient, positioning the ablating member in a desired position to ablate tissue, emitting ablating energy from the ablating member to form an ablated tissue area and removing the ablating member from the patient.

Claims

1. A method for trans-esophageal ablation of cardiac tissue in a patient comprising:

providing a trans-esophageal ablation device comprising a flexible, elongate portion adapted to be guided within an esophagus of said patient, a source of energy, and a two-dimensional array of transducer elements configured to deliver high intensity focused ultrasound (HIFU) energy to a focus zone within said patient, the focus zone being at a predetermined distance from the trans-esophageal ablation device;

inserting said trans-esophageal ablation device into an esophagus of said patient;

positioning said two-dimensional array of transducer elements of said trans-esophageal ablation device proximate esophagus tissue at the predetermined distance from said cardiac tissue of said patient;

focusing said focus zone of said two-dimensional array of transducer elements on said cardiac tissue of said patient; and

delivering high intensity focused ultrasound (HIFU) energy to said cardiac tissue of said patient to form a lesion at said cardiac tissue within said focus zone without forming a lesion in patient esophagus tissue proximate said trans-esophageal ablation device;

wherein said two-dimensional array of transducer elements have a taper wherein transducer elements positioned more centrally in said two-dimensional array of transducer elements are larger than transducer elements positioned more peripherally in said two-dimensional array of transducer elements, and further wherein the step of delivering high intensity focused ultrasound (HIFU) energy to said cardiac tissue includes operating said two-dimensional array of transducer elements to focus said high intensity focused ultrasound (HIFU) energy from said two-dimensional array of transducer elements to said focus zone within said patient.

2. The method of claim 1 wherein said high intensity focused ultrasound (HIFU) energy delivered from said two-dimensional array of transducer elements is at least approximately three decibels greater intensity at said focus zone in comparison with a grating lobe.

3. The method of claim 1 wherein said trans-esophageal ablation device further comprises an impedance match circuit operatively coupled to the two-dimensional array of transducer elements, and wherein said focusing step comprises providing, at least in part, an approximately equal impedance for each transducer element of said two-dimensional array of transducer elements.

4. The method of claim 3 wherein said impedance is approximately fifty ohms at a temperature of zero degrees centigrade.

5. The method of claim 1, wherein each transducer element of said two-dimensional array of transducer elements are independently actuatable, and wherein said focusing step comprises independently actuating each transducer element.

6. The method of claim 1, wherein the step of delivering high intensity focused ultrasound (HIFU) energy to said cardiac tissue of said patient to form a lesion at said cardiac tissue includes focusing said high intensity focused ultrasound (HIFU) energy through a wall of said esophagus and into said cardiac tissue.

7. The method of claim 1, wherein the step of inserting said trans-esophageal ablation device into an esophagus of said patient includes inserting said trans-esophageal ablation device through an oral cavity of said patient.

8. The method of claim 1, wherein the step of positioning said two-dimensional array of said trans-esophageal ablation device at the predetermined distance from said cardiac tissue includes using transesophageal echocardiography (TEE).

9. The method of claim 1, further comprising:

manipulating a tissue-engaging device apart from said trans-esophageal ablation device to move a heart of said patient to position cardiac tissue of said heart at the predetermined distance from said trans-esophageal ablation device.

10. The method of claim 1, wherein each transducer element of said two-dimensional array of transducer elements are selectively actuatable to allow for electronic steering of said high intensity focused ultrasound (HIFU) energy.

11. A method for trans-esophageal ablation of cardiac tissue in a patient comprising:

providing an ablation device configured to ablate cardiac tissue from within an esophagus of the patient, the ablation device configured to deliver high intensity focused ultrasound (HIFU) energy to a focus zone at a predetermined distance from an array of transducer elements;

wherein the array of transducer elements have a taper wherein individual transducer elements positioned more centrally in the array are larger than individual transducer elements positioned more peripherally in the array;

inserting the ablation device into the esophagus;

positioning the array of transducer elements proximate esophagus tissue at the predetermined distance from cardiac tissue;

focusing the focus zone on cardiac tissue to be ablated; and

delivering high intensity focused ultrasound (HIFU) energy through the wall of the esophagus to ablate cardiac tissue within the focus zone without ablating esophagus tissue proximate the array of transducer elements.

12. The method of claim 11, wherein each transducer element of the array of transducer elements are selectively actuatable to allow for electronic steering of said high intensity focused ultrasound (HIFU) energy.