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Methods for treating hypercholesterolemia and reducing LDL-C using antibodies to PCSK9

  • US 9,724,411 B2
  • Filed: 12/09/2013
  • Issued: 08/08/2017
  • Est. Priority Date: 12/15/2008
  • Status: Active Grant
First Claim
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1. A method for treating hypercholesterolemia in a patient, the method comprising administering to the patient a first dose of a pharmaceutical composition comprising an antibody or antigen-binding fragment thereof that specifically binds hPCSK9, wherein the amount of the antibody in the first dose is 75 mg (“

  • the 75 mg dose”

    );

    and administering to the patient a second dose of a pharmaceutical composition comprising the antibody or antigen-binding fragment thereof that specifically binds hPCSK9, wherein the amount of antibody in the second dose is 150 mg (“

    the 150 mg dose”

    );

    wherein the 150 mg dose is administered to the patient two weeks after the 75 mg dose;

    wherein the antibody or antigen-binding fragment that specifically binds hPCSK9 comprises the heavy and light chain CDRs of a HCVR/LCVR amino acid sequence pair selected from the group consisting of SEQ ID NOs;

    90/92 and 218/226.

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