Peptide systems and methods for metabolic conditions
First Claim
1. A method, comprising:
- administering, to the skin of a subject having a metabolic condition, a composition comprising an effective amount of thyrotropin-releasing hormone (TRH) and molecular nitric oxide to treat the metabolic condition, and a carrier having a phosphatidylcholine component entrapping the molecular nitric oxide, wherein the composition is stable at room temperature.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention generally relates to compositions and methods for topical or transdermal delivery, and treatment of metabolic conditions. In some cases, the composition may include nitric oxide and/or peptides such as thyrotropin-releasing hormone (TRH) and/or GnRH (gonadotropin-releasing hormone). The nitric oxide and/or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other structures containing nitric oxide, peptides, or both. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.
206 Citations
20 Claims
-
1. A method, comprising:
administering, to the skin of a subject having a metabolic condition, a composition comprising an effective amount of thyrotropin-releasing hormone (TRH) and molecular nitric oxide to treat the metabolic condition, and a carrier having a phosphatidylcholine component entrapping the molecular nitric oxide, wherein the composition is stable at room temperature. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
-
13. A method, comprising contacting the skin of a subject having a metabolic condition with a composition comprising:
an emulsion comprising a first phase comprising a thyrotropin-releasing hormone (TRH), molecular nitric oxide, and lecithin, and a second phase comprising an emulsifier, wherein the lecithin is present at least about 0.25% by weight of the composition, and wherein the first phase comprises no more than about 250 ppm of water by weight of the composition. - View Dependent Claims (14, 15, 16)
-
17. A method, comprising:
administering, to the skin of a subject having a metabolic condition, a composition comprising a first phase comprising an effective amount of thyrotropin-releasing hormone (TRH), molecular nitric oxide, and phosphatidylcholine to treat the metabolic condition, and a second phase comprising an emulsion, wherein the composition comprises no more than about 250 ppm of water by weight of the composition. - View Dependent Claims (18, 19, 20)
Specification