Implantable electroacupuncture system and method for treating parkinson's disease and essential tremor through application of stimului at or near an acupoint on the chorea line

• US 9,724,512 B2
• Filed: 01/29/2015
• Issued: 08/08/2017
• Est. Priority Date: 09/28/2012
• Status: Active Grant

• Current Assignee: Valencia Bioscience, Inc.
• Original Assignee: Valencia Technologies Corporation
• Inventors: Peterson, David K. L., Chambliss, Stacy Greiner
• Primary Examiner(s): Wehrheim, Lindsey G
• Application Number:
  US14/609,108
• Publication Number:
  US 20150148864A1
• Time in Patent Office: 922 Days
• CPC Class Codes: A61N 1/0504 Subcutaneous electrodes
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36125 Details of circuitry or electric components
• CPC Class Codes: A61N 1/3616 Voltage density or current density
• CPC Class Codes: A61N 1/36175 Pulse width or duty cycle
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators
• CPC Class Codes: A61N 1/3758 Packaging of the components within the casing
• CPC Class Codes: A61N 1/3782 producing a voltage above the power source level

Abstract

An implantable electroacupuncture device (IEAD) treats Parkinson'"'"'s disease or Essential Tremor through application of stimulation pulses applied to at least one of the acupoints on the chorea line. The IEAD includes an hermetically-sealed implantable electroacupuncture (EA) device and a conduit extending therefrom. At least one electrode is located on the outside of the housing. At least one electrode is located at an opening formed through the conduit. The housing contains a primary power source and pulse generation circuitry. A sensor wirelessly senses externally-generated operating commands, such as ON, OFF and AMPLITUDE. The pulse generation circuitry generates stimulation pulses. The stimulation pulses are applied to the specified acupoint or nerve through the electrodes in accordance with a specified stimulation regimen.

Claims

1. An Implantable ElectroAcupuncture System (IEAS) configured to treat Parkinson'"'"'s disease or Essential Tremor of a patient, comprising:

an implantable electroacupuncture (EA) device comprising a hermetically-sealed housing containing a primary power source and pulse generation circuitry powered by the primary power source, wherein the pulse generation circuitry is configured to generate stimulation pulses in accordance with a specified stimulation regimen;

a plurality of leads in electrical communication with the pulse generation circuitry and defining a plurality of electrodes that are individually controllable by the pulse generation circuitry, wherein each lead included in the plurality of leads defines a particular electrode included in the plurality of electrodes; and

a conduit extending from the housing and carrying the plurality of leads, the conduit comprising a first opening pair that includes a first opening and a second opening formed through the conduit and longitudinally spaced along a length of the conduit, wherein a first electrode included in the plurality of electrodes is located proximate to the first opening and a second electrode included in the plurality of electrodes is located proximate to the second opening;

wherein the pulse generation circuitry is configured to apply the stimulation pulses to one or more acupoints along a chorea line within the patient by way of the first and second electrodes and through the first and second openings.

2. An Implantable ElectroAcupuncture System (IEAS) configured to treat Parkinson'"'"'s disease or Essential Tremor within a patient, comprising:

an implantable electroacupuncture (EA) device comprising a hermetically-sealed housing containing a primary power source and pulse generation circuitry powered by the primary power source, wherein the pulse generation circuitry is configured to generate stimulation pulses in accordance with a specified stimulation regimen, wherein a portion of an outside of the housing electrically coupled with the pulse generation circuitry and defines a first electrode having a first polarity;

a single lead in electrical communication with the pulse generation circuitry and defining a second electrode having a second polarity; and

a conduit extending from the housing and carrying the single lead, the conduit comprising a first opening pair that includes a first opening and a second opening formed through the conduit and longitudinally spaced along a length of the conduit, the second electrode located proximate to the first and second openings;

wherein the first opening and the second opening each have a longitudinal length as defined by a dimension of the first and second openings measured along a longitudinal length of the conduit, the longitudinal length of the first opening is 20-80% of a longitudinal distance between a center of the first opening and a center of the second opening, and

wherein the pulse generation circuitry is configured to apply the stimulation pulses to one or more acupoints along a chorea line within the patient by way of the first and second electrodes and through the first and second openings.

3. The IEAS of claim 2, wherein the longitudinal length of the second opening is 20-80% of the longitudinal distance between the center of the first opening and a center of the second opening.

4. The IEAS of claim 3, wherein the longitudinal length of the first opening is the same as the longitudinal length of the second opening.

5. The IEAS of claim 4, wherein the conduit further comprises a second opening pair that includes a third opening and a fourth opening formed through the conduit and longitudinally spaced along the length of the conduit, the second electrode also located proximate to the third and fourth openings.

6. The IEAS of claim 5, wherein the longitudinal distance between the first and second openings is the same as a longitudinal distance between the third and fourth openings.

7. The IEAS of claim 5, wherein the longitudinal distance between the first and second openings is different than a longitudinal distance between the third and fourth openings.

8. The IEAS of claim 2, wherein the longitudinal length of the first opening is different than the longitudinal length of the second opening.

9. The IEAS of claim 8, wherein the conduit further comprises a second opening pair that includes a third opening and a fourth opening formed through the conduit and longitudinally spaced along the length of the conduit, the second electrode also located proximate to the third and fourth openings.

10. The IEAS of claim 9, wherein the longitudinal distance between the first and second openings is the same as the longitudinal distance between the third and fourth openings.

11. The IEAS of claim 9, wherein the longitudinal distance between the first and second openings is different than the longitudinal distance between the third and fourth openings.

12. The IEAS of claim 2, wherein the first and second openings each vary in size according to an intensity of the stimulation pulses necessary to treat a given location on the chorea line.

13. An Implantable ElectroAcupuncture System (IEAS) configured to treat Parkinson'"'"'s disease or Essential Tremor within a patient, comprising:

an implantable electroacupuncture (EA) device comprising a hermetically-sealed housing containing a primary power source and pulse generation circuitry powered by the primary power source, wherein the pulse generation circuitry is configured to generate stimulation pulses in accordance with a specified stimulation regimen;

a plurality of leads in electrical communication with the pulse generation circuitry and defining a plurality of electrodes, wherein each lead included in the plurality of leads defines a particular electrode included in the plurality of electrodes; and

a conduit extending from the housing and carrying the plurality of leads, the conduit comprising a first opening pair that includes a first opening and a second opening formed through the conduit and longitudinally spaced along a length of the conduit, wherein a first electrode included in the plurality of electrodes is located proximate to the first opening and a second electrode included in the plurality of electrodes is located proximate to the second opening;

wherein the first opening and the second opening each have a longitudinal length as defined by a dimension of the first and second openings as measured along a longitudinal length of the conduit, the longitudinal length of the first opening is 20-80% of a longitudinal distance between a center of the first opening and a center of the second opening, and

wherein the pulse generation circuitry is configured to apply the stimulation pulses to one or more acupoints along a chorea line within the patient by way of the first and second electrodes and through the first and second openings.

14. The IEAS of claim 13, wherein the longitudinal length of the second opening is 20-80% of the longitudinal distance between the center of the first opening and a center of the second opening.

15. The IEAS of claim 14, wherein:

the plurality of electrodes further comprises a third electrode and a fourth electrode;

the conduit further comprises a second opening pair that includes by a third opening and a fourth opening formed through the conduit and longitudinally spaced along the length of the conduit, the third electrode located proximate to the third opening and the fourth electrode located proximate to the fourth opening.

16. The IEAS of claim 15, wherein the longitudinal distance between the first and second openings is the same as a longitudinal distance between the third and fourth openings.

17. The IEAS of claim 15, wherein the longitudinal distance between the first and second openings is different than the longitudinal distance between the third and fourth openings.