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CD27 single chain molecules and encoding nucleic acids

  • US 9,725,495 B2
  • Filed: 06/03/2016
  • Issued: 08/08/2017
  • Est. Priority Date: 07/21/2008
  • Status: Active Grant
First Claim
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1. A single-chain fusion polypeptide comprising:

  • (a) a first soluble CD27 ligand (CD27L) cytokine domain,(b) a first peptide linker,(c) a second soluble CD27L cytokine domain,(d) a second peptide linker, and(e) a third soluble CD27L cytokine domain,wherein each of the soluble CD27L cytokine domains lacks a stalk region and the first and the second peptide linkers independently have a length of 3-8 amino acids.

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