CD27 single chain molecules and encoding nucleic acids
First Claim
Patent Images
1. A single-chain fusion polypeptide comprising:
- (a) a first soluble CD27 ligand (CD27L) cytokine domain,(b) a first peptide linker,(c) a second soluble CD27L cytokine domain,(d) a second peptide linker, and(e) a third soluble CD27L cytokine domain,wherein each of the soluble CD27L cytokine domains lacks a stalk region and the first and the second peptide linkers independently have a length of 3-8 amino acids.
0 Assignments
0 Petitions
Accused Products
Abstract
The present invention refers to single-chain fusion proteins comprising three soluble TNF superfamily (TNFSF) cytokine domains and nucleic acid molecules encoding these fusion proteins. The fusion proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
-
Citations
16 Claims
-
1. A single-chain fusion polypeptide comprising:
-
(a) a first soluble CD27 ligand (CD27L) cytokine domain, (b) a first peptide linker, (c) a second soluble CD27L cytokine domain, (d) a second peptide linker, and (e) a third soluble CD27L cytokine domain, wherein each of the soluble CD27L cytokine domains lacks a stalk region and the first and the second peptide linkers independently have a length of 3-8 amino acids. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
-
-
2. A single-chain fusion polypeptide comprising:
-
(a) a first soluble CD27 ligand (CD27L) cytokine domain, (b) a first peptide linker, (c) a second soluble CD27L cytokine domain, (d) a second peptide linker, and (e) a third soluble CD27L cytokine domain, wherein each of the soluble CD27L cytokine domains lacks a stalk region and the first and the second peptide linkers independently have a length of 3-8 amino acids, wherein the first, the second, and the third soluble CD27L cytokine domains are independently an N-terminally shortened domain of SEQ ID NO;
7, and optionally consists of an amino acid mutation.
-
Specification