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Treatment of ‘C terminus of HSP7O-interacting protein’ (CHIP) related diseases by inhibition of natural antisense transcript to CHIP

  • US 9,725,756 B2
  • Filed: 06/05/2014
  • Issued: 08/08/2017
  • Est. Priority Date: 08/21/2009
  • Status: Active Grant
First Claim
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1. A synthetic, oligonucleotide of 15-25 nucleotides in length having at least one modification wherein the at least one modification is selected from:

  • at least one modified sugar moiety;

    at least one modified internucleotide linkage;

    at least one modified nucleotide, and combinations thereof;

    wherein said oligonucleotide is an antisense compound which is 100% complementary to and specifically hybridizes to a complementary 15-25 nucleotide region of a natural antisense polynucleotide of a ‘

    C terminus of HSP70-Interacting Protein (CHIP) polynucleotide having SEQ ID NOS;

    2 or 3 and upregulates the function and/or expression of a ‘

    C terminus of HSP70-Interacting Protein’

    (CHIP) gene in vivo or in vitro as compared to a normal control.

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