Articles of manufacture releasing an active ingredient

• US 9,730,483 B2
• Filed: 08/13/2010
• Issued: 08/15/2017
• Est. Priority Date: 07/18/2008
• Status: Active Grant

• Current Assignee: Nntt Tech Inc.
• Original Assignee: BioMed Concepts, Inc.
• Inventors: Theberge, Karine, Goudreault, Isabelle, Quirion, Francois, Perron, Gerald
• Primary Examiner(s): YOUNG, MICAH PAUL
• Application Number:
  US12/855,778
• Publication Number:
  US 20100305209A1
• Time in Patent Office: 2,559 Days
• Field of Search: 424465-489
• CPC Class Codes: A43B 1/0045 made at least partially of deodorant means
• CPC Class Codes: A43B 17/003 characterised by the material made of wood A43B17/12, made of sponge, rubber or plastic materials A43B17/14
• CPC Class Codes: A61K 2800/56 Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
• CPC Class Codes: A61K 8/0208 Tissues; Wipes; Patches
• CPC Class Codes: A61K 8/0241 Containing particulates characterized by their shape and/or structure see also A61K8/04, A61K8/11, and A61K8/14, further aspects are classified in A61K2800/40 and subcodes
• CPC Class Codes: A61K 8/553 Phospholipids, e.g. lecithin
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/1617 Organic compounds, e.g. phospholipids, fats
• CPC Class Codes: A61K 9/70 Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug hollow drug-filled fibres A61K9/0092
• CPC Class Codes: A61L 15/42 Use of materials characterised by their function or physical properties liquid bandages A61L26/00
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 2300/602 Type of release, e.g. controlled, sustained, slow
• CPC Class Codes: A61L 2300/622 Microcapsules
• CPC Class Codes: A61L 2300/802 Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
• CPC Class Codes: A61M 35/00 Devices for applying media, e.g. remedies, on the human body devices for handling toiletry or cosmetic substances A45D; absorbent pads, e.g. swabs, A61F13/15
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: D06M 23/08 Processes in which the treating agent is applied in powder or granular form adhesives for multi-layer textile fabrics D06M17/00
• CPC Class Codes: D06M 23/12 Processes in which the treating agent is incorporated in microcapsules making microcapsules B01J13/02

Abstract

The present invention relates to articles of manufacture having a formulation distributed therein, wherein the formulation comprises an active agent which manifests a desirable property when released from the articles of manufacture. The present invention also relates to methods for manufacturing these articles of manufacture, to vehicles for applying the formulation to these articles of manufacture, and to perception indicators indicating the presence and the amount of formulation comprising an active agent applied to an article of manufacture.

Claims

1. A method for obtaining a formulation of hydrophobic topical application microparticles having an active ingredient dispersed therein, wherein the formulation is suitable for application to a living subject;

said method comprising;

a) forming a formulation comprising a stirred melt of the active ingredient and a non-crosslinked hydrophobic carrier material, wherein the non-crosslinked hydrophobic carrier material is a lipid, a fatty acid-based lipid, a phospholipid, a wax, a fatty acid, a glyceride, a sterol, or any combination thereof; and

b) homogenizing the formulation of a) and obtaining microparticles from the homogenized formulation of a), wherein the microparticles have a body, the body comprising a central part and a surface, the central part and the surface including the non-crosslinked hydrophobic carrier material throughout which is uniformly dispersed the active ingredient;

wherein the microparticles are responsive to one or more of temperature and pH of the living subject to trigger progressive erosion of the surface and the subsequent progressive erosion of the central part to release the non-crosslinked hydrophobic carrier material and the active ingredient, and wherein the microparticles have all three dimensions in the range of about 0.1 micrometers to about 200 micrometers.

2. A method as defined in claim 1, wherein the microparticles have a release index of between about 1 and about 20.

3. A method as defined in claim 1, wherein step b) comprises homogenization to obtain microdroplets.

4. A method as defined in claim 3, further comprising cooling the microdroplets to obtain microparticles.

5. A method as defined in claim 1, wherein the non-crosslinked hydrophobic carrier material is caproic acid, caprylic acid, capric acid, undecanoic acid, lauric acid, tridecanoic acid, myristic acid, pentadecanoic acid, palmitic acid, heptadecanoic acid, stearic acid, oleic acid, elaidic acid, linoleic acid, linolenic acid, arachidic acid, arachidonic acid, a fatty acid derivative, tripalmitin, tristearin or glycerol monostearate or any combination thereof.

6. A method as defined in claim 1, wherein the non-crosslinked hydrophobic carrier material includes a composition of stearic acid and palmitic acid.

7. A method as defined in claim 1, wherein the non-crosslinked hydrophobic carrier material includes a composition of stearic acid, palmitic acid and a natural butter.

8. A method as defined in claim 7, wherein the natural butter is olive butter, mango butter, grape seed butter, shea butter or lemon butter or any combination thereof.

9. A method as defined in claim 1, wherein the formulation further comprises a surfactant.

10. A method as defined in claim 9, wherein the surfactant includes an ionic or a nonionic surfactant.

11. A method as defined in claim 9, wherein the surfactant includes cetyl trimethylammonium chloride (CTAC).

12. A method as defined in claim 1, further comprising transferring the microparticles to a substrate that is a textile or a fabric.

13. A method as defined in claim 1, further comprising adding a perception indicator to the formulation of a).

14. A method as defined in claim 1, further comprising the step of adding an ancillary agent to the formulation.

15. A method as defined in claim 12, wherein the microparticles are responsive to body heat established in proximity of the substrate to progressively erode and release the active ingredient.

16. A method as defined in claim 1, wherein the non-crosslinked hydrophobic carrier material melts at a temperature between about 31°

C. and 34°

C.