Narrow band in-vivo imaging device

• US 9,730,573 B2
• Filed: 03/20/2007
• Issued: 08/15/2017
• Est. Priority Date: 03/20/2007
• Status: Active Grant

• Current Assignee: Given Imaging Limited (Medtronic Plc)
• Original Assignee: Given Imaging Limited (Medtronic Plc)
• Inventors: Pascal, Amit
• Primary Examiner(s): Santos Rodriguez, Joseph M
• Application Number:
  US11/723,500
• Publication Number:
  US 20080234548A1
• Time in Patent Office: 3,801 Days
• Field of Search: 600160, 600167, 600407, 600424, 600476
• CPC Class Codes: A61B 1/041 Capsule endoscopes for imaging
• CPC Class Codes: A61B 1/0625 for multiple fixed illumination angles
• CPC Class Codes: A61B 1/0638 providing two or more wavelengths

Abstract

An in-vivo imaging device for capturing one or more narrow band images of the gastrointestinal tract, or other body lumens or cavities of a patient, using one or more narrow band illumination sources and an imager having an array of light sensitive elements.

Claims

1. An in-vivo imaging device for providing at least first and second narrow band images of an in-vivo target area, the in-vivo imaging device comprising:

a first type and a second type of narrow band illumination sources of light radiation for simultaneously illuminating the target area and giving rise to reflected radiation therefrom, the first and second types of illumination sources having non-overlapping first and second illumination spectra; and

an imager to simultaneously capture said at least first and second images based on simultaneously receiving the radiation reflected from the target area by illumination from the first and second types of illumination sources, the imager comprising an array of a first and a second types of light sensitive elements covered by wavelength sensitive filters and having differing first and second sensitivity spectra, the first and the second types of light sensitive elements being responsive to the first and the second illumination spectra, respectively,

wherein values of full width half maximum (FWHM) of the first and the second illumination spectra are less than values of FWHM of the first and the second sensitivity spectra, respectively,

wherein values of center wavelength and of FWHM of the first illumination spectrum are such that an overlap between the first sensitivity spectrum and the first illumination spectrum is larger than an overlap between the first sensitivity spectrum and the second illumination spectrum,

and wherein values of center wavelength and of FWHM of the second illumination spectrum are such that an overlap between the second sensitivity spectrum and the second illumination spectrum is larger than an overlap between the second sensitivity spectrum and the first illumination spectrum.

2. The in-vivo imaging device according to claim 1, wherein the overlap between the first sensitivity spectrum and the first illumination spectrum-is greater or equal to five times the overlap between the first sensitivity spectrum and the second illumination spectrum.

3. The in-vivo imaging device according to claim 1, wherein the overlap between the second sensitivity spectrum and the second illumination spectrum is greater or equal to five times the overlap between the second sensitivity spectrum and the first illumination spectrum.

4. The in-vivo imaging device according to claim 1, further comprising:

a third type of narrow band illumination source of light radiation for illuminating the target area simultaneously with the first and second types of illumination source and giving rise to reflected radiation therefrom, the third type of illumination source having a third illumination spectrum non-overlapping the first and second illumination spectra,

wherein the imager to simultaneously receive the radiation reflected from the target by illumination from the first, second and third types of illumination sources, and to capture a third image simultaneously with the first and the second images,

wherein the array further comprising a third type of light sensitive element having a third sensitivity spectrum differing from the first and the second sensitivity spectra, the third type of light sensitive element being responsive to the third illumination spectrum,

wherein the value of FWHM of the third illumination spectrum is less than value of FWHM of the third sensitivity spectrum,

and wherein the value of center wavelength and of FWHM of the third illumination spectrum is such that an overlap between the third sensitivity spectrum and the third illumination spectrum is larger than an overlap between the third sensitivity spectrum and the other illumination spectrum.

5. The in-vivo imaging device according to claim 4, wherein the overlap between the third sensitivity spectrum and the third illumination spectrum is greater or equal to five times the overlap between the third sensitivity spectrum and the other illumination spectra.

6. The in-vivo imaging device according to claim 4, wherein the array is a planar array.

7. The in-vivo imaging device according to claim 4, wherein the array is a mosaic array.

8. The in-vivo imaging device according to claim 7, wherein the light sensitive elements are arranged in repeating groups of four.

9. The in-vivo imaging device according to claim 8, wherein each group comprises four adjacent light sensitive elements made up of two green light sensitive elements, one red light sensitive element and one blue light sensitive element.

10. The in-vivo imaging device according to claim 4, wherein the center wavelength of the third illumination spectrum of being greater than center wavelength of the third sensitivity spectrum.

11. The in-vivo imaging device according to claim 1, wherein the center wavelength of the first illumination spectrum are less than center wavelength of the first sensitivity spectrum.

12. The in-vivo imaging device according to claim 1, wherein the center wavelength of the second illumination spectrum of being greater than center wavelength of the second sensitivity spectrum.

13. The in-vivo imaging device according to claim 1, comprising a swallowable capsule.

14. An in-vivo imaging device for narrow band imaging comprising:

a plurality of narrow band illumination sources having non-overlapping corresponding illumination spectra; and

an imager comprising a plurality of light sensitive elements covered by wavelength sensitive filters and having differing corresponding sensitivity spectra arranged in a mosaic array for capturing a plurality of narrow band images simultaneously,

wherein each of the plurality of light sensitive elements is responsive to a corresponding illumination spectra,

wherein values of full width half maximum (FWHM) of each of the plurality of illumination spectra is less than the corresponding values of FWHM of sensitivity spectra, respectively, and

wherein values of FWHM of each of the plurality of illumination spectra are such that for each pair of corresponding illumination source and light sensitive element, an overlap between sensitivity spectrum of the light sensitive element and the corresponding illumination spectrum is larger than overlaps of the sensitivity spectrum and illumination spectra of other illumination sources.

15. The in-vivo imaging device according to claim 14, wherein the plurality of narrow band illumination sources includes at least two types of narrow band illumination sources.

16. The in-vivo imaging device according to claim 14, wherein the plurality of light sensitive elements includes at least three different types of light sensitive elements, each type being responsive to a narrow band illumination source having a given illumination spectrum.

17. The in-vivo imaging device according to claim 15, wherein the light sensitive elements are arranged in groups of four and wherein each group comprises four adjacent light sensitive elements made up of two green light sensitive elements, one red light sensitive element and one blue light sensitive element.

18. A method for providing a plurality of narrow band images of an in-vivo target area by an in-vivo imaging device, the method comprising:

simultaneously illuminating the target area by a plurality of narrow band illumination sources of light radiation having non-overlapping corresponding illumination spectra; and

capturing the plurality of narrow band images simultaneously based on simultaneously receiving radiation reflected from the target area by an imager comprising an array of a plurality of light sensitive elements covered by wavelength sensitive filters and having differing corresponding sensitivity spectra,

wherein each of the plurality of light sensitive elements is responsive to a corresponding illumination spectra,

wherein values of full width half maximum (FWHM) of each of the plurality of illumination spectra are less than the corresponding values of FWHM of sensitivity spectra, respectively, and

wherein values of FWHM of each of the plurality of illumination spectra are such that for each pair of corresponding illumination source and light sensitive element, an overlap between sensitivity spectrum of the light sensitive element and the corresponding illumination spectrum is larger than overlaps of the sensitivity spectrum and illumination spectra of other illumination sources.

19. The method of claim 18, wherein for each of the plurality of light sensitive elements, the overlap between the sensitivity spectrum of the light sensitive element and the corresponding illumination spectrum is greater or equal to five times the overlap between the sensitivity spectrum and the other illumination spectra.

20. The method of claim 18, wherein the array is a planar array.

21. The method of claim 18, wherein the array is a mosaic array.

22. The method of claim 21, wherein each group comprises four adjacent light sensitive elements made up of two green light sensitive elements, one red light sensitive element and one blue light sensitive element.

23. The method of claim 21, wherein the light sensitive elements are arranged in repeating groups of four.

24. The method of claim 18, wherein the plurality of narrow band illumination sources includes at least two types of narrow band illumination sources.

25. The method of claim 18, wherein the plurality of light sensitive elements includes at least three different types of light sensitive elements, each type being responsive to a narrow band illumination source having a given illumination spectrum.