Kinetics of physiological response to activity during activities of daily living
First Claim
Patent Images
1. An apparatus comprising:
- an activity sensor circuit, configured to receive information indicative of physical activity of a subject during the subject'"'"'s activities of daily living and to generate an activity signal;
a physiological sensor circuit, configured to receive physiological information during the subject'"'"'s activities of daily living and concurrent with the information indicative of physical activity, and to generate an actual physiological response signal different from the activity signal;
a signal processor circuit, configured to receive a template comprising a plurality of data values characterizing a relationship between the information indicative of physical activity and the physiological information, and generate an approximate physiological response signal including performing a mathematical convolution operation of the activity signal with the template, the approximate physiological response signal representative of the actual physiological response signal,wherein the signal processor circuit is further configured to;
compare information from the approximate physiological response signal, generated using the mathematical convolution, with information from the actual physiological response signal;
when the comparison fails to meet at least one specified criterion, adjust the template and generate a corresponding approximate physiological response signal including performing the mathematical convolution operation of the activity signal with the adjusted template, until the comparison meets the specified criterion;
when the comparison meets the at least one specified criterion, extract from the template at least one characteristic parameter and generate an indicator of kinetics of physiological response to a change in activity (PRA); and
use information from the at least one characteristic parameter to determine a diagnostic indicating a change of cardiac status related to the kinetics of PRA; and
a therapy circuit coupled to the signal processor circuit, the therapy circuit configured to deliver a therapy to the subject based at least on the determined diagnostic.
1 Assignment
0 Petitions
Accused Products
Abstract
A physiological response to activity (PRA) during a subject'"'"'s activities of daily living (ADL) can be used, such as to generate useful diagnostic information about the subject. This can involve using a template, such as an impulse response template. The technique can be used with an implantable or other ambulatory medical monitoring or therapy device, such as a cardiac function management device, or with a local or remote external interface device.
-
Citations
19 Claims
-
1. An apparatus comprising:
-
an activity sensor circuit, configured to receive information indicative of physical activity of a subject during the subject'"'"'s activities of daily living and to generate an activity signal; a physiological sensor circuit, configured to receive physiological information during the subject'"'"'s activities of daily living and concurrent with the information indicative of physical activity, and to generate an actual physiological response signal different from the activity signal; a signal processor circuit, configured to receive a template comprising a plurality of data values characterizing a relationship between the information indicative of physical activity and the physiological information, and generate an approximate physiological response signal including performing a mathematical convolution operation of the activity signal with the template, the approximate physiological response signal representative of the actual physiological response signal, wherein the signal processor circuit is further configured to; compare information from the approximate physiological response signal, generated using the mathematical convolution, with information from the actual physiological response signal; when the comparison fails to meet at least one specified criterion, adjust the template and generate a corresponding approximate physiological response signal including performing the mathematical convolution operation of the activity signal with the adjusted template, until the comparison meets the specified criterion; when the comparison meets the at least one specified criterion, extract from the template at least one characteristic parameter and generate an indicator of kinetics of physiological response to a change in activity (PRA); and use information from the at least one characteristic parameter to determine a diagnostic indicating a change of cardiac status related to the kinetics of PRA; and a therapy circuit coupled to the signal processor circuit, the therapy circuit configured to deliver a therapy to the subject based at least on the determined diagnostic. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
-
-
11. A non-transitory device-readable medium including instructions that, when performed by the device, comprise:
-
receiving information indicative of physical activity of a subject during the subject'"'"'s activities of daily living and generating an activity signal; receiving physiological information during the subject'"'"'s activities of daily living and concurrent with the information indicative of physical activity and generating an actual physiological response signal, different from the activity signal; receiving a template comprising a plurality of data values; generating an approximate physiological response signal that is representative of the actual physiological response signal, including; performing a mathematical convolution operation of the activity signal with the template for generating the approximate physiological response signal; comparing information from the approximate physiological response signal, generated using the mathematical convolution, with information from the actual physiological response signal; when the comparison fails to meet at least one specified criterion, adjusting the template and performing the mathematical convolution operation of the activity signal with the adjusted template, until the comparison meets the specified criterion; and when the comparison meets the at least one specified criterion, extracting from the template at least one characteristic parameter indicative of kinetics of physiological response to a change in activity; using information from the at least one characteristic parameter to determine a diagnostic indicating a change of cardiac status; and delivering a therapy to the subject based at least on the determined diagnostic. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19)
-
Specification