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Kinetics of physiological response to activity during activities of daily living

  • US 9,730,618 B2
  • Filed: 02/10/2011
  • Issued: 08/15/2017
  • Est. Priority Date: 02/16/2010
  • Status: Active Grant
First Claim
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1. An apparatus comprising:

  • an activity sensor circuit, configured to receive information indicative of physical activity of a subject during the subject'"'"'s activities of daily living and to generate an activity signal;

    a physiological sensor circuit, configured to receive physiological information during the subject'"'"'s activities of daily living and concurrent with the information indicative of physical activity, and to generate an actual physiological response signal different from the activity signal;

    a signal processor circuit, configured to receive a template comprising a plurality of data values characterizing a relationship between the information indicative of physical activity and the physiological information, and generate an approximate physiological response signal including performing a mathematical convolution operation of the activity signal with the template, the approximate physiological response signal representative of the actual physiological response signal,wherein the signal processor circuit is further configured to;

    compare information from the approximate physiological response signal, generated using the mathematical convolution, with information from the actual physiological response signal;

    when the comparison fails to meet at least one specified criterion, adjust the template and generate a corresponding approximate physiological response signal including performing the mathematical convolution operation of the activity signal with the adjusted template, until the comparison meets the specified criterion;

    when the comparison meets the at least one specified criterion, extract from the template at least one characteristic parameter and generate an indicator of kinetics of physiological response to a change in activity (PRA); and

    use information from the at least one characteristic parameter to determine a diagnostic indicating a change of cardiac status related to the kinetics of PRA; and

    a therapy circuit coupled to the signal processor circuit, the therapy circuit configured to deliver a therapy to the subject based at least on the determined diagnostic.

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