Devices and methods for shaping therapy in fluid enhanced ablation

• US 9,730,748 B2
• Filed: 03/10/2014
• Issued: 08/15/2017
• Est. Priority Date: 04/12/2011
• Status: Active Grant

• Current Assignee: Thermedical, Inc.
• Original Assignee: Thermedical, Inc.
• Inventors: Curley, Michael G.
• Primary Examiner(s): PEFFLEY, MICHAEL F
• Application Number:
  US14/202,425
• Publication Number:
  US 20140188106A1
• Time in Patent Office: 1,254 Days
• CPC Class Codes: A61B 18/04 by heating by applying electromagnetic radiation A61B18/18; hyperthermia using electric or magnetic fields, radiation or ultrasound A61N
• CPC Class Codes: A61B 18/082 Probes or electrodes therefor
• CPC Class Codes: A61B 18/1477 Needle-like probes
• CPC Class Codes: A61B 18/16 Indifferent or passive electrodes for grounding
• CPC Class Codes: A61B 2017/00526 Methods of manufacturing
• CPC Class Codes: A61B 2018/00029 open
• CPC Class Codes: A61B 2018/00041 Heating, e.g. defrosting
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/00642 with feedback, i.e. closed loop control
• CPC Class Codes: A61B 2018/00773 Sensed parameters
• CPC Class Codes: A61B 2018/00791 Temperature
• CPC Class Codes: A61B 2018/00797 measured by multiple temperature sensors
• CPC Class Codes: A61B 2018/00809 measured thermochromatically
• CPC Class Codes: A61B 2018/00821 measured by a thermocouple
• CPC Class Codes: A61B 2018/046 in liquid form
• CPC Class Codes: A61B 2018/1425 Needle
• CPC Class Codes: A61B 2018/162 located on the probe body
• CPC Class Codes: F04B 17/03 driven by electric motors
• CPC Class Codes: F04B 19/22 of reciprocating-piston type
• CPC Class Codes: F04B 41/02 having reservoirs
• CPC Class Codes: F04B 43/04 : Pumps having electric drive
• CPC Class Codes: F04B 49/06 : Control using electricity regulating by means of floats actuating electric switches F04B49/04
• CPC Class Codes: F04C 2270/041 : Controlled or regulated
• CPC Class Codes: Y10T 29/49016 : Antenna or wave energy "plumbing" making
• CPC Class Codes: Y10T 29/49085 : Thermally variable

Abstract

Devices and methods for shaping an ablation treatment volume formed in fluid enhanced ablation therapy are provided. The devices and methods disclosed herein utilize the interaction of fluids to create ablation treatment volumes having a variety of shapes. In one embodiment, a method for forming an ablation treatment volume having a desired shape includes delivering therapeutic energy to tissue to form an ablation treatment volume and simultaneously delivering a first fluid and a second fluid to the tissue. The first and second fluids can convect the therapeutic energy in a desired direction such that the ablation treatment volume has a desired shape.

Claims

1. A method for forming an ablation treatment volume in tissue having a desired shape, comprising:

positioning an ablation device having an elongate shaft and three elongate bodies extending from a distal end of the elongate shaft such that the three elongate bodies extend into tissue;

delivering therapeutic energy to the tissue from only a first of the three elongate bodies to form an ablation treatment volume in the tissue; and

simultaneously delivering a first fluid from the first elongate body and a second fluid from the other two elongate bodies to the tissue, the first and second fluids convecting the therapeutic energy in a desired direction such that the ablation treatment volume has a desired non-spherical shape;

wherein each of the plurality of elongate bodies is offset from one another and spaced along an axis that defines a diameter of the elongate shaft with the first elongate body disposed between the other two elongate bodies.

2. The method of claim 1, wherein the first and second fluids are delivered at different temperatures.

3. The method of claim 2, further comprising heating at least one of the first fluid and the second fluid using a heating assembly disposed within an inner lumen of at least one of the three elongate bodies.

4. The method of claim 3, wherein the first fluid is heated using a first heating assembly disposed within a first inner lumen of the first elongate body to a temperature in excess of 41°

C.

5. The method of claim 4, wherein the second fluid is heated to a temperature below 41°

C.

6. The method of claim 1, further comprising adjusting any of a fluid flow rate and a fluid temperature for any of the first fluid and the second fluid to further shape the ablation treatment volume.

7. The method of claim 1, further comprising adjusting a level of therapeutic energy delivered to the tissue to further shape the ablation treatment volume.

8. The method of claim 1, wherein delivering therapeutic energy to tissue comprises activating an ablation element configured to transmit electrical energy into the tissue.

9. The method of claim 8, wherein the ablation element is disposed on the first elongate body.

10. The method of claim 1, further comprising repeating the steps of delivering therapeutic energy and simultaneously delivering a first fluid and a second fluid in a plurality of locations to form a treatment volume having an elongate planar shape.

11. The method of claim 1, wherein the second fluid is delivered from only a second of the three elongate bodies and the method further comprises delivering a third fluid from a third of the three elongate bodies simultaneously with delivering the first and second fluids.

12. The method of claim 1, wherein the elongate shaft is a catheter and positioning the ablation device includes introducing the elongate shaft into a patient'"'"'s body via the circulatory system.

13. The method of claim 1, wherein simultaneously delivering each of the first and second fluids includes passing fluid from an inner lumen of each elongate body into tissue through at least one outlet port formed in each elongate body.

14. A method for shaping therapeutic energy delivered to tissue comprising:

positioning an ablation device relative to tissue, wherein the ablation device includes an elongate shaft having;

a first elongate body centrally disposed on and extending from a distal end of the elongate shaft, the first elongate body having an inner lumen extending therethrough, at least one outlet port formed therein, at least one ablation element disposed along a length thereof, and at least one heater element disposed within the inner lumen;

a second elongate body extending from the distal end of the elongate shaft and offset from the first elongate body along an axis that defines a diameter of the elongate shaft, the second elongate body having an inner lumen extending therethrough and at least one outlet port formed therein;

a third elongate body extending from the distal end of the elongate shaft and offset from the first elongate body along the axis in a direction opposite of the second elongate body offset, the third elongate body having an inner lumen extending therethrough and at least one outlet port formed therein; and

simultaneously delivering a first fluid from the first elongate body and a second fluid from the second and third elongate bodies such that the first and second fluids interact to shape a non-spherical ablation treatment volume.

15. The method of claim 14, wherein the first fluid and the second fluid are at different temperatures.

16. The method of claim 14, further comprising delivering therapeutic energy from the ablation element disposed along the first elongate body.

17. The method of claim 14, wherein any of the second elongate body and the third elongate body is positioned at a location adjacent to a structure to be protected from therapeutic energy.

18. A method for forming an ablation treatment volume in tissue having a desired shape, comprising:

delivering therapeutic energy to tissue to form an ablation treatment volume in the tissue; and

simultaneously delivering a first fluid and a second fluid to the tissue, the first and second fluids convecting the therapeutic energy in a desired direction such that the ablation treatment volume has a desired shape;

wherein the first fluid is delivered from first and second opposed longitudinal portions of an inner lumen of an elongate body, and the second fluid is delivered from third and fourth opposed longitudinal portions of the inner lumen, the third and fourth portions being radially offset from the first and second portions.

19. A method for forming an ablation treatment volume in tissue having a desired shape, comprising:

delivering therapeutic energy to tissue to form an ablation treatment volume in the tissue; and

simultaneously delivering a first fluid and a second fluid to the tissue, the first and second fluids convecting the therapeutic energy in a desired direction such that the ablation treatment volume has a desired shape;

wherein delivering the first fluid comprises ejecting the first fluid from at least one outlet port formed in a proximal portion of a sidewall of an elongate member, and delivering the second fluid comprises ejecting the second fluid from at least one outlet port formed in a distal portion of a sidewall of an elongate member adjacent to the proximal portion.