Patch system for in-situ therapeutic treatment

• US 9,735,893 B1
• Filed: 07/21/2016
• Issued: 08/15/2017
• Est. Priority Date: 07/21/2016
• Status: Active Grant

• Current Assignee: Exo Imaging Inc.
• Original Assignee: Intel Corporation
• Inventors: Baxi, Amit Sudhir, Elsherbini, Adel A., Oster, Sasha N., Eid, Feras, Aleksov, Aleksandar, Mageshkumar, Vincent S., Huang, Wen-Ling M., Ranganathan, Kumar, Swan, Johanna M.
• Primary Examiner(s): West, Lewis
• Application Number:
  US15/216,502
• Time in Patent Office: 390 Days
• CPC Class Codes: A61B 5/0024 for multiple sensor units attached to the patient, e.g. using a body or personal area network
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/1102 Ballistocardiography
• CPC Class Codes: A61B 5/1107 Measuring contraction of parts of the body, e.g. organ, muscle apparatus for measuring work or force in general G01L
• CPC Class Codes: A61B 5/1121 Determining geometric values, e.g. centre of rotation or angular range of movement
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61B 5/333 Recording apparatus specially adapted therefor
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/4869 Determining body composition
• CPC Class Codes: A61B 5/6833 Adhesive patches
• CPC Class Codes: A61F 7/007 characterised by electric heating
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61N 1/0484 Garment electrodes worn by the patient
• CPC Class Codes: A61N 1/0492 Patch electrodes A61N1/0412, A61N1/0428 take precedence
• CPC Class Codes: A61N 1/3603 Control systems
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092
• CPC Class Codes: H04B 5/22 : Capacitive coupling

Abstract

Discussed generally herein are methods and devices including or providing a patch system that can help in diagnosing a medical condition and/or provide therapy to a user. A body-area network can include a plurality of communicatively coupled patches that communicate with an intermediate device. The intermediate device can provide data representative of a biological parameter monitored by the patches to proper personnel, such as for diagnosis and/or response.

Claims

1. A system comprising:

a first patch including;

a first flexible, stretchable substrate, a first adhesive on the first flexible, stretchable substrate, the first adhesive configured to temporarily attach the first patch to skin of a user, and first electronics on or at least partially in the first flexible, stretchable substrate, the first electronics including at least one first component to provide therapy to the user and a first wireless radio, and

a second patch including;

a second flexible, stretchable substrate, a second adhesive on the second flexible, stretchable substrate, the second adhesive configured to temporarily attach the second patch to the skin of the user, and second electronics on or at least partially in the second flexible, stretchable substrate, the second electronics including at least one second component to monitor a first biological parameter of the user; and

a wireless communication device communicatively coupled to the first wireless radio of the first electronics, the wireless communication device including processing circuitry to receive data corresponding to the first biological parameter and provide one or more signals to the first patch to adjust an amount of the therapy provided by the first patch.

2. The system of claim 1, wherein the at least one first component includes at least one of a vesicle and a needle and the therapy includes medicine, the at least one first component includes an ultrasonic transducer and the therapy include ultrasonic waves, and the at least one first component includes one or more conductive pads coupled to power delivery circuitry and the therapy includes electrical stimulation.

3. The system of claim 1, wherein the wireless communication device is further communicatively coupled to a second wireless radio of the second electronics to receive the data corresponding to the first biological parameter.

4. The system of claim 3, wherein the first patch operates in a master role including the first wireless radio communicatively coupled to the second wireless radio and the second wireless radio is not communicatively coupled to the wireless communication device.

5. The system of claim 1, further comprising:

a third patch including;

a third flexible, stretchable substrate, a third adhesive on the third flexible, stretchable substrate, the third adhesive configured to temporarily attach the third patch to the skin of the user, and third electronics on or at least partially in the third flexible, stretchable substrate, the third electronics including at least one third component to monitor a second biological parameter of the user and a third wireless radio, the second biological parameter different from the first biological parameter, the third wireless radio communicatively coupled to at least one of the first wireless radio, the second wireless radio, and the wireless communication device.

6. The system of claim 5, wherein the third wireless radio is communicatively coupled to the second wireless radio and the second wireless radio is communicatively coupled to the first wireless radio and the second and third wireless radios are not communicatively coupled to the wireless communication device.

7. The system of claim 1, wherein the first biological parameter includes one of flexion, contraction, stretch, temperature, electrical activity a specific force, angular rate, magnetic field, salinity, muscular activity of the heart, electrical activity of the heart, pulse, oxygen content, lactate content, pressure, organ or conduit volume, blood pressure, blood glucose level, and electro-dermal activity.

8. The system of claim 1, wherein the second patch is configured to be situated partially in an armpit with a first portion of the electronics on a first electronics substrate configured to be situated in the armpit and a second portion of the electronics on a second electronics substrate electrically coupled to the first portion of the electronics and configured to be situated outside of the armpit.

9. The system of claim 8, wherein the first electronics substrate is flexible and the second electronics substrate is rigid.

10. The system of claim 1, wherein the second wireless radio and the first wireless radio are configured to communicate directly with the wireless communication device.

11. A method comprising:

attaching, using a first adhesive on a first flexible, stretchable substrate, a first patch to skin of a user at a first location;

attaching, using a second adhesive on a second flexible, stretchable substrate, a second patch to the skin of the user at a second, different location;

monitoring, using second electronics on or at least partially in the second flexible, stretchable substrate, a first biological parameter of the user during a first time frame;

providing, using one of a first wireless radio of the first electronics and a second wireless radio of the second electronics, signals corresponding to the first biological parameter to a wireless communication device; and

providing, using the first electronics on or at east partially in the first substrate and during the first time frame, a therapy to the user.

12. The method of claim 11, wherein a first component of the first electronics includes an ultrasonic transducer and the therapy includes ultrasonic therapy.

13. The method of claim 11, wherein a first component of the first electronics includes at least one conductive pad and the therapy includes electro-therapy provided through the at least one conductive pad.

14. The method of claim 11, wherein a first component of the first electronics includes at least one of a vesicle and a needle and the therapy includes a medication provided through the at least one vesicle and the at least one needle.

15. The method of claim 11, further comprising:

attaching, using a third adhesive on a third flexible, stretchable substrate, a third patch to skin of a user at a third location;

monitoring, using third electronics on or at least partially in the third flexible, stretchable substrate, a second biological parameter of the user during the first time frame; and

providing, using one of the first wireless radio of the first electronics and the second wireless radio of the second electronics, signals corresponding to the second biological parameter to the wireless communication device.

16. The method of claim 11, further comprising:

receiving, from the wireless communication device and at one of the first wireless radio of the first electronics and the second wireless radio of the second electronics, signals indicating a change to the therapy provided by the first electronics, the change to the therapy determined based on the signals corresponding to the first biological parameter; and

adjusting an amount or a schedule of therapy delivery based on the signals from the wireless communication device.

17. A system comprising:

a body area network comprising at least two patches, each of the at least two patches including a flexible, stretchable substrate, an adhesive on the flexible, stretchable substrate, the adhesive configured to temporarily attach the patch to skin of a user, and electronics on or at least partially in the flexible, stretchable substrate, the electronics including a wireless radio and at least one of a first component to provide therapy to the user and a second component to monitor a first biological parameter of the user; and

a wireless communication device communicatively coupled to at least one patch of the at least two patches of the body area network, the wireless communication device including processing circuitry to receive data corresponding to the biological parameter and provide one or more signals to a first patch of the at least two patches to adjust an amount of the therapy provided by the first patch.

18. The system of claim 17, wherein each patch of the at least two patches is communicatively coupled to the wireless communication device to communicate directly with the wireless communication device.

19. The system of claim 17, wherein only one patch of the at least two patches is communicatively coupled to the wireless communication device to communicate data from all patches of the at least two patches to the wireless communication device.

20. The system of claim 17, wherein a first patch of the at least two patches is configured to perform a role of a master patch during a first time frame and all other patches of the at least two patches provide data to the first patch during the first time frame and a second patch of the at least two patches is configured to perform the role of the master patch during a second time frame different from the first time frame and all other patches of the at least two patches provide data to the second patch during the second time frame.