Charged particle cancer therapy beam state determination apparatus and method of use thereof

• US 9,737,272 B2
• Filed: 07/11/2016
• Issued: 08/22/2017
• Est. Priority Date: 05/22/2008
• Status: Active Grant

• Current Assignee: ProTom International Holding Corporation
• Original Assignee: Daniel J. Raymond, Lee W. Davis, Mark R. Amato, Susan L. Michaud
• Inventors: Lee, W. Davis, Michaud, Susan L., Raymond, Daniel J., Amato, Mark R.
• Primary Examiner(s): SMYTH, ANDREW P
• Application Number:
  US15/207,309
• Publication Number:
  US 20160317836A1
• Time in Patent Office: 407 Days
• Field of Search: None
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/4216 using storage phosphor screens
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: A61B 6/5205 involving processing of raw data to produce diagnostic data
• CPC Class Codes: A61N 2005/1054 using a portal imaging system
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 2005/1095 Elements inserted into the radiation path within the system, e.g. filters or wedges
• CPC Class Codes: A61N 2005/1097 Means for immobilizing the patient
• CPC Class Codes: A61N 5/1044 with multiple repetitions of the scanning pattern
• CPC Class Codes: A61N 5/1067 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/107 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/1077 Beam delivery systems
• CPC Class Codes: A61N 5/1082 having multiple beam rotation axes
• CPC Class Codes: G21K 1/08 Deviation, concentration or focusing of the beam by electric or magnetic means electron-optical arrangements in electric discharge tubes H01J29/46; details, e.g. electric or magnetic deviating means for direct voltage accelerators or in accelerators using single pulses H05H5/02; arrangements for injecting particles into orbits H05H7/08; arrangements for ejecting particles from orbits H05H7/10
• CPC Class Codes: G21K 5/04 with beam-forming means

Abstract

The invention comprises an apparatus and method of use thereof for determining a charged particle beam state after passage through a final beam modification insert and prior to entering a patient, such as in cancer treatment or tomographic imaging. The insert comprises a range shifter, a known energy absorber, a ridge filter, a focal length altering insert, an aperture defining element, a compensator, and/or a patient specific beam modifier. The monitoring element comprises one or more sheets, configured to emit photons upon passage therethrough of the charged particle beam, where the emitted photons are detected, tested, such as against a predetermined cancer treatment plan, and/or used to aid in three dimensional tomographic image generation.

Claims

1. A method for determination of a state of positively charged particles of a charged particle beam entering a patient along a beam path, comprising the steps of:

using a beam transport system to transport the positively charged particles from a synchrotron to an exit nozzle,

a slideably insertable beam insert positioned proximate said exit nozzle;

reshaping the charged particle beam using the beam insert;

positioning a first imaging sheet in the beam path between said beam insert and the patient; and

imaging first photons emitted from said first imaging sheet using a detector system, wherein, resultant from transmission of the positively charged particles transmitting through said first imaging sheet, said first imaging sheet emits the first photons;

positioning a second imaging sheet in the beam path between said first imaging sheet and the patient; and

imaging second photons emitted from said second imaging sheet using said detector system, wherein, resultant from transmission of the positively charged particle transmitting through said second imaging sheet, said second imaging sheet emits the second photons; and

further comprising the step of;

verifying direction of the beam path against a radiation treatment plan using two signals from said detector system, said two signals comprising a first position signal representative of a first location of the first photons emitted from said first imaging sheet and a second position signal representative of a second location of the second photons emitted from the second imaging sheet.

2. The method of claim 1, further comprising the step of:

verifying position of the charged particle beam against a radiation treatment plan for the patient using a signal from said detector system resultant from the first photons.

3. The method of claim 2, further comprising the step of:

verifying intensity of the charged particle beam against the radiation treatment plan using an intensity of the signal.

4. The method of claim 1, further comprising the step of:

determining a beam path vector using a first detected location of the first photons and a second detected location of the second photons in tomographic reconstruction of a three-dimensional image of the tumor.

5. The method of claim 1, said step of reshaping further comprising the step of:

changing a focal point of the charged particle beam using said beam insert, said beam insert comprising a ridge filter.

6. The method of claim 1, further comprising the step of:

said detector system detecting;

(1) the first photons at a first wavelength and (2) the second photons at a second wavelength, said first imaging sheet at least one centimeter from said second imaging sheet in the beam path.

7. The method of claim 6, the second wavelength at least fifty nanometers greater than the first wavelength.

8. The method of claim 1, further comprising the step of:

moving both said exit nozzle and said imaging sheet with a gantry; and

during said step of moving, maintaining a relative orientation of a detection element of said detection system, said first imaging sheet, and said exit nozzle.

9. The method of claim 8, further comprising the steps of:

using said detection system to determine;

(1) a first position of emission of said first photons and (2) a second position of emission of the second photons; and

using the first position and the second position as input data for a step of a three-dimensional tomographic image construction of the tumor.

10. The method of claim 9, further comprising the step of:

detecting a position of the positively charged particles after transmitting through the tumor using a detection element.

11. An apparatus for determination of a state of positively charged particles of a charged particle beam entering a patient along a beam path, comprising:

a beam transport system configured to transport the positively charged particles from a synchrotron to an exit nozzle;

a slideably insertable beam insert positioned proximate said exit nozzle;

a first imaging sheet positioned in the beam path between the beam insert and the patient during use; and

a detector system configured to image said first imaging sheet, said first imaging sheet configured to emit first photons upon transmission of the positively charged particles through said first imaging sheet;

a second imaging sheet positioned between said first imaging sheet and the patient during use, said first imaging sheet at least one centimeter from said second imaging sheet in the beam path, said second imaging sheet configured to locally emit second photons upon passage of the positively charged particles; and

verifying direction of the beam path against a radiation treatment plan using two signals from said detector system, said two signals comprising a first position signal representative of a first location of the first photons emitted from said first imaging sheet and a second position signal representative of a second location of the second photons emitted from the second imaging sheet.

12. The apparatus of claim 11, said detector system further comprising:

a first detector array optically coupled to said first imaging sheet; and

a second detector array optically coupled to said second imaging sheet.

13. The apparatus of claim 11, further comprising:

a first optically coupled path of the first photons to said detector system; and

a second optically coupled path of the second photons to said detector system, said second optically coupled path comprising an absorbance filter, said absorbance filter comprising an absorbance of greater than fifty percent of photons at a first wavelength of said first photons.

14. The apparatus of claim 11, further comprising:

a tomographic imaging detection element positioned on an opposite side of said first imaging sheet from said beam insert.

15. The apparatus of claim 14, further comprising:

a gantry configured to co-rotate about an axis all of;

said tomographic imaging detection element, said first imaging sheet, and said beam insert.

16. An apparatus for determination of a state of positively charged particles of a charged particle beam entering a patient along a beam path, comprising:

a beam transport system configured to transport the positively charged particles from a synchrotron to an exit nozzle;

a slideably insertable beam insert positioned proximate said exit nozzle;

a first imaging sheet positioned in the beam path between the beam insert and the patient during use; and

a detector system configured to image said first imaging sheet, said first imaging sheet configured to emit first photons upon transmission of the positively charged particles through said first imaging sheet; and

further comprising;

a second imaging sheet positioned between said first imaging sheet and said tomographic imaging detection element,

said second imaging sheet configured to emit second photons upon transmission of the positively charged particles through said second imaging sheet; and

verifying direction of the beam path against a radiation treatment plan using two signals from said detector system, said two signals comprising a first position signal representative of a first location of the first photons emitted from said first imaging sheet and a second position signal representative of a second location of the second photons emitted from the second imaging sheet.

17. The apparatus of claim 16, said tomographic imaging detection element comprising a scintillation material.