Percutaneously deliverable heart valve including folded membrane cusps with integral leaflets
CAFCFirst Claim
1. A transcatheter, implantable, prosthetic heart valve, comprising:
- a lattice frame; and
two or more integrated cusp and leaflet folded structures attached to the lattice frame, the two or more integrated cusp and leaflet folded structures each comprising a flat sheet of biocompatible membrane that has been folded to include a mobile leaflet section and a cusp wall section, wherein non-transverse diagonally oriented folds that are angled relative to an axial flow direction are located between the mobile leaflet section and the cusp wall section, wherein the cusp wall section is located radially outside of the mobile leaflet section, and wherein the cusp wall section includes a seam that joins apposing sides of the cusp wall section.
1 Assignment
1 Petition
Accused Products
Abstract
A transcatheter, percutaneously implantable, prosthetic heart valve is provided that comprises a lattice frame and two or more integrated cusp and leaflet folded structures attached to the lattice frame. The two or more integrated cusp and leaflet folded structures each comprise a flat sheet of biocompatible membrane that is folded to include a substantially conical shape according to a flat folding pattern. The substantially conical shape is further formed by joining apposing sides of the substantially conical shape along a seam. The two or more integrated cusp and leaflet folded structures are each attached along their respective seams to the lattice frame in a direction substantially parallel to an axis of the lattice frame. Embodiments of valves described herein have application within the entire vascular system.
521 Citations
85 Claims
-
1. A transcatheter, implantable, prosthetic heart valve, comprising:
-
a lattice frame; and two or more integrated cusp and leaflet folded structures attached to the lattice frame, the two or more integrated cusp and leaflet folded structures each comprising a flat sheet of biocompatible membrane that has been folded to include a mobile leaflet section and a cusp wall section, wherein non-transverse diagonally oriented folds that are angled relative to an axial flow direction are located between the mobile leaflet section and the cusp wall section, wherein the cusp wall section is located radially outside of the mobile leaflet section, and wherein the cusp wall section includes a seam that joins apposing sides of the cusp wall section. - View Dependent Claims (2, 3, 4, 25, 26, 27, 28, 73, 81)
-
-
5. A transcatheter, implantable, prosthetic heart valve, comprising:
-
a lattice frame; and two or more integrated cusp and leaflet folded structures attached to the lattice frame, the two or more integrated cusp and leaflet folded structures each comprising a flat sheet of a biocompatible membrane that has been folded along non-transverse diagonal folds that are angled relative to an axial flow direction, wherein the folded biocompatible membrane includes a valve cusp according to a flat folding pattern. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 29, 30, 74)
-
-
18. In subcombination, an integrated cusp and leaflet structure for attachment to a lattice frame to form a valve configured for implantation in a vascular system of a patient, the integrated cusp and leaflet structure comprising:
a flat sheet of a biocompatible membrane that has been folded to include a mobile leaflet section and a cusp wall section, wherein non-transverse diagonally oriented folds angled relative to an axial flow direction are located between the mobile leaflet section and the cusp wall section, wherein the cusp wall section is divided along a seam, and wherein the mobile leaflet section is continuous with the cusp wall section and apposes the cusp wall section when the mobile leaflet section is in a position corresponding to an open operating configuration. - View Dependent Claims (19, 20, 21, 22, 23, 24, 31, 32, 33, 75, 82)
-
34. A transcatheter, implantable, prosthetic heart valve, comprising:
-
a lattice frame; and two or more integrated cusp and leaflet folded structures attached to the lattice frame, the two or more integrated cusp and leaflet folded structures each comprising a flat sheet of a biocompatible membrane that has been folded to include a valve cusp according to a flat folding pattern, wherein non-transverse diagonally oriented folds angled relative to an axial flow direction are located between a mobile leaflet section and a cusp wall section of each of the integrated cusp and leaflet folded structures, and wherein the flat folding pattern is polygonal and includes extending portions that extend along a circumferential course from the valve cusp and form at least a portion of an integral, inner, luminal, sealing cuff. - View Dependent Claims (35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 76)
-
-
46. A transcatheter, implantable, prosthetic heart valve, comprising:
-
a lattice frame; and two or more integrated cusp and leaflet folded structures attached to the lattice frame, the two or more integrated cusp and leaflet folded structures each comprising a flat sheet of biocompatible membrane that has been folded to include a mobile leaflet section, a cusp wall section and a cuff wall section, wherein non-transverse diagonally oriented folds angled relative to an axial flow direction are located between the mobile leaflet section and the cusp wall section, wherein the mobile leaflet section apposes and substantially directly overlaps the cusp wall section, wherein the cuff wall section resides radially exterior to the cusp wall section and the mobile leaflet section, and wherein the cuff wall section resides adjacent a portion of a surface of the lattice frame. - View Dependent Claims (47, 48, 49, 50, 51, 52, 53, 54, 77)
-
-
55. A vascular system implant, comprising:
-
a lattice frame; and a plurality of substantially conical shaped cusps attached to the lattice frame, wherein each of the plurality of substantially conical shaped cusps includes a biocompatible membrane, and wherein each of the plurality of substantially conical shaped cusps include non-transverse diagonally oriented folds that are angled relative to an axial flow direction. - View Dependent Claims (56, 57, 58, 59, 78, 83)
-
-
60. A vascular system implant, comprising:
-
a lattice frame; and a plurality of non-rectangular polygonal mobile leaflets attached to the lattice frame, wherein each of the plurality of non-rectangular polygonal mobile leaflets includes a biocompatible membrane, and wherein each of the plurality of non-rectangular polygonal mobile leaflets are bordered by non-transverse diagonally oriented folds that are angled relative to an axial flow direction. - View Dependent Claims (61, 62, 63, 64, 65, 66, 79, 84)
-
-
67. A vascular system implant, comprising:
-
a lattice frame; and at least two folded biocompatible membrane sheets attached to the lattice frame, wherein each of the at least two folded biocompatible membrane sheets has been formed to include a non-rectangular polygonal mobile leaflet, wherein each of the non-rectangular polygonal mobile leaflets include non-transverse diagonally oriented folds that are angled relative to an axial flow direction. - View Dependent Claims (68, 69, 70, 71, 72, 80, 85)
-
Specification