Nucleic acid particles, methods and use thereof
First Claim
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1. A particle, comprising:
- a core, comprising one or more self-assembled nucleic acid molecules in a crystalline structure comprising a lamellar sheet, wherein addition of a film coating to the particle converts the core from a first configuration to a second configuration, wherein the first configuration has a first greatest dimension that is greater than 2 μ
m and;
the second configuration has a second greatest dimension that is less than 500 nm.
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Abstract
The present invention provides, among other things, a particle which includes a core comprised of self-assembled one or more nucleic acid molecules, the core being characterized by an ability to adopt at least two configurations: a first configuration having a first greatest dimension greater than 2 μm and; a second configuration having a second greatest dimension less than 500 nm, wherein addition of a film coating converts the core from its first configuration to its second configuration. Methods of making and using of provided particles are also disclosed.
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Citations
51 Claims
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1. A particle, comprising:
a core, comprising one or more self-assembled nucleic acid molecules in a crystalline structure comprising a lamellar sheet, wherein addition of a film coating to the particle converts the core from a first configuration to a second configuration, wherein the first configuration has a first greatest dimension that is greater than 2 μ
m and;
the second configuration has a second greatest dimension that is less than 500 nm.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51)
Specification