×

Hydrophobic core carrier compositions for delivery of therapeutic agents, methods of making and using the same

  • US 9,737,615 B2
  • Filed: 11/22/2013
  • Issued: 08/22/2017
  • Est. Priority Date: 12/19/2005
  • Status: Active Grant
First Claim
Patent Images

1. A composition, consisting of:

  • (i) a polymeric carrier; and

    (ii) a plurality of hydrophobic groups with a covalently linked protective side chain, wherein the hydrophobic group has a first end that is covalently linked to the carrier and a second end that is covalently linked to the protective side chain,wherein each hydrophobic group of the plurality of hydrophobic groups comprises an alkyl group of 8-36 carbons and has a molecular weight between 150 to 1000 Daltons independent of the carrier and protective side chain weights;

    wherein the protective side chain is polyethylene glycol, polypropylene glycol, a co-polymer of polyethylene glycol and polypropylene glycol, or an alkoxy derivative thereof;

    wherein the protective side chain has a molecular weight between about 400 and 20,000 Daltons independent of the carrier and hydrophobic group weights;

    wherein the weight ratio of the protective side chains to the hydrophobic groups is more than 17;

    1; and

    wherein the composition is soluble in an aqueous solvent.

View all claims
  • 0 Assignments
Timeline View
Assignment View
    ×
    ×