Cardiac pacemaker and uses thereof

• US 9,737,720 B2
• Filed: 07/18/2016
• Issued: 08/22/2017
• Est. Priority Date: 03/27/2012
• Status: Active Grant

• Current Assignee: University of Vermont & State Agricultural College
• Original Assignee: University of Vermont & State Agricultural College
• Inventors: Meyer, Markus
• Primary Examiner(s): Stice, Paula J
• Application Number:
  US15/212,708
• Publication Number:
  US 20160325103A1
• Time in Patent Office: 400 Days
• Field of Search: 607 6- 9
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371
• CPC Class Codes: A61N 1/36507 controlled by gradient or slope of the heart potential
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585
• CPC Class Codes: A61N 1/36535 controlled by body position or posture
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

The invention relates to improved cardiac pacemakers and methods of use thereof. In particular the cardiac pacemakers are useful for normalizing heart rates over resting heart rates in order to condition the heart to improve overall cardiac output.

Claims

1. A cardiac pacemaker for implantation within a subject, the pacemaker comprising:

a housing;

at least one motion sensor configured to detect movement of the subject and produce output indicative of the movement; and

at least one processor in the housing, the at least one processor being responsive to the output from the sensor and configured to produce a pacing signal when the output from the at least one motion sensor indicates the subject is at rest, the pacing signal being configured to increase a heart rate of the subject above a resting heart rate level, wherein the pacing signal is configured to stimulate remodeling of the subject'"'"'s heart muscle.

2. The cardiac pacemaker of claim 1, wherein the at least one processor is further configured to stop producing the pacing signal when the output from the at least one sensor indicates the subject is active.

3. The cardiac pacemaker of claim 1, wherein the at least one processor determines that the subject is at rest by detecting a lack of movement of the subject for a first period of time.

4. The cardiac pacemaker of claim 3, wherein the first period of time is 5 minutes.

5. The cardiac pacemaker of claim 1, further including an input circuit that receives a signal representative of a heartbeat sensed within a heart as a function of time.

6. The cardiac pacemaker of claim 1, wherein the pacing signal is configured to increase the heart rate of the subject to a heart rate between 90 beats per minute and 150 beats per minute.

7. The cardiac pacemaker of claim 1, wherein the at least one processor is further configured to adjust the pacing signal over time based on the output from the at least one motion sensor.

8. The cardiac pacemaker of claim 7, wherein adjusting the pacing signal over time comprises:

producing a first pacing signal configured to increase the heart rate of the subject to a first heart rate above the resting heart rate level;

detecting output from the at least one motion sensor that indicates the subject has remained at rest; and

in response to said detecting, producing a second pacing signal configured to increase the heart rate of the subject to a second heart rate above the resting heart rate level, the second heart rate being higher than the first heart rate.

9. The cardiac pacemaker of claim 1, wherein the output from the at least one motion sensor indicates the subject is sleeping.