Charged particle state determination apparatus and method of use thereof

• US 9,737,733 B2
• Filed: 05/27/2016
• Issued: 08/22/2017
• Est. Priority Date: 05/22/2008
• Status: Active Grant

• Current Assignee: ProTom International Holding Corporation
• Original Assignee: Lee W. Davis, Stephen L. Spotts, Susan L. Michaud
• Inventors: Lee, W. Davis, Spotts, Stephen L., Michaud, Susan L.
• Primary Examiner(s): McCormack, Jason
• Application Number:
  US15/167,617
• Publication Number:
  US 20160271424A1
• Time in Patent Office: 452 Days
• Field of Search: 2504921, 2504923, 2504931
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: A61B 6/5205 involving processing of raw data to produce diagnostic data
• CPC Class Codes: A61N 2005/105 using a laser alignment system
• CPC Class Codes: A61N 2005/1054 using a portal imaging system
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 2005/1095 Elements inserted into the radiation path within the system, e.g. filters or wedges
• CPC Class Codes: A61N 2005/1097 Means for immobilizing the patient
• CPC Class Codes: A61N 5/1037 taking into account the movement of the target, e.g. 4D-image based planning
• CPC Class Codes: A61N 5/1044 with multiple repetitions of the scanning pattern
• CPC Class Codes: A61N 5/1067 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/1069 Target adjustment, e.g. moving the patient support
• CPC Class Codes: A61N 5/107 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/1077 Beam delivery systems
• CPC Class Codes: A61N 5/1082 having multiple beam rotation axes
• CPC Class Codes: G21K 1/08 Deviation, concentration or focusing of the beam by electric or magnetic means electron-optical arrangements in electric discharge tubes H01J29/46; details, e.g. electric or magnetic deviating means for direct voltage accelerators or in accelerators using single pulses H05H5/02; arrangements for injecting particles into orbits H05H7/08; arrangements for ejecting particles from orbits H05H7/10
• CPC Class Codes: G21K 5/04 with beam-forming means

Abstract

The invention comprises a system for determining the state of a charged particle beam, such as beam position, intensity, and/or energy. For example, the charged particle beam state is determined at or about a patient undergoing charged particle cancer therapy using one or more film layers designed to emit photons upon passage of a charged particle beam, which yields information on position and/or intensity of the charged particle beam. The emitted photons are used to calculate position of the treatment beam in imaging and/or during tumor treatment. Optionally and preferably, updating a tomography map uses the same hardware with the same alignment used for cancer therapy at proximately the same time.

Claims

1. A method for determining a charged particle beam state, comprising the steps of:

extracting positively charged particles from a synchrotron;

transporting the positively charged particles from said synchrotron through a nozzle and at least into a patient;

imaging first photons to form a first signal, the first photons resultant from the positively charged particles transmitting through a first light emitting element on a first sheet;

imaging second photons to form a second signal, the second photons emitted from a second light emitting element upon the positively charged particles traversing through the second light emitting element on a second sheet, said second sheet parallel to said first sheet and not intersecting said first sheet;

determining a first vector of the positively charged particle beam path using the first signal and the second signal.

2. The method of claim 1, further comprising the steps of:

positioning the first light emitting element in a beam path of the positively charged particles after the patient;

positioning the second light emitting element in the beam path of the positively charged particles after the patient, said first light emitting element separated from said second light emitting element by at least one centimeter; and

using the first vector to determine an exit point of the positively charged particles from the patient.

3. The method of claim 1, further comprising the steps of:

positioning the first light emitting element in a beam path of the positively charged particles prior to the patient;

positioning the second light emitting element in the beam path of the positively charged particles prior to the patient, said first light emitting element separated from said second light emitting element by at least one centimeter; and

using the first vector to determine an entrance point of the positively charged particles into the patient.

4. The method of claim 2, further comprising the step of:

using the first vector, during a tumor therapy session, to confirm a position of a tumor of the patient.

5. The method of claim 2, further comprising the step of:

after positioning the patient relative to said nozzle in a treatment room;

(1) changing a treatment plan of irradiation of a tumor of the patient using the first vector; and

(2) resuming treatment of a tumor of the patient prior to the patient leaving the treatment room using said synchrotron.

6. The method of claim 2, further comprising the steps of:

imaging third photons to form a third signal, the third photons emitted from a third light emitting element upon the positively charged particles passing through said third light emitting element, said third light emitting element positioned between said nozzle and the patient.

7. The method of claim 6, further comprising the steps of:

imaging fourth photons to form a fourth signal, the fourth photons emitted from a fourth light emitting element upon the positively charged particles passing through said fourth light emitting element, said fourth light emitting element positioned between said nozzle and the patient;

determining a second vector of the positively charged particle beam path using said third signal and said fourth signal; and

using the second vector to determine an entrance point of the positively charged particles into the patient.

8. The method of claim 7, further comprising the step of:

calculating a probable path of the positively charged particles through the patient using the entrance point and the exit point.

9. The method of claim 6, further comprising the steps of:

determining a position of the positively charged particles through;

(1) positioning the positively charged particles along a first axis using a first pair of magnets and (2) positioning the positively charged particles along a second axis using a second pair of magnets, the first axis perpendicular to the second axis;

determining a second vector of the positively charged particle beam path using the position and the third signal; and

using the second vector to determine an entrance point of the positively charged particles into the patient.

10. The method of claim 6, further comprising the step of:

using a scintillation plate of a tomography detector to determine a fourth signal of a position of the positively charged particle beam in said scintillation plate; and

using said third signal and said fourth signal to determine a second measure of the exit point of the positively charged particles from the patient.

11. The method of claim 1, said step of imaging first photons further comprising the step of:

determining a first measure of an intensity of the positively charged particles using a magnitude of the first signal, said first signal comprising a measure to the first photons resultant from the positively charged particles transmitting through said first light emitting element.

12. The method of claim 1, further comprising the step of:

using the magnitude of the first signal related to the first photons to determine a dosage per unit time of the positively charged particles.

13. The method of claim 12, the step of imaging second photons further comprising the step of:

determining a second measure of the intensity of the positively charged particles using an amplitude of the second signal, said second signal comprising a measure to the second photons resultant from the positively charged particles transmitting through said second light emitting element.

14. The method of claim 12, further comprising the step of:

determining a first measure of an energy of the positively charged particles using a peak-to-peak period of a radio-frequency field applied to the positively charged particles in said synchrotron at time of extraction.

15. The method of claim 14, further comprising the step of:

determining a second measure of an energy of the positively charged particles using a scintillation detector positioned in a path of the positively charged particles after the patient.

16. The method of claim 2, said first light emitting element comprising a fluorophore.

17. An apparatus for determining a charged particle beam state, comprising:

a synchrotron configured to extract positively charged particles;

a nozzle, the positively charged particles transported from said synchrotron through said nozzle and at least into a patient;

a first detector imaging first photons to form a first signal, the first photons resultant from the positively charged particles transmitting through a first light emitting element on a first sheet;

a second detector imaging second photons to form a second signal, the second photons emitted from a second light emitting element upon the positively charged particles traversing through the second light emitting element on a second sheet, said first sheet parallel to said second sheet, said first sheet not intersecting said second sheet;

a controller determining a first vector of the positively charged particle beam path using the first signal and the second signal.

18. The apparatus of claim 17, said nozzle further comprising:

an insert comprising an aperture to form a cross-sectional shape the positively charged particles.